Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control.

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
12 Oct 2023
Historique:
pubmed: 24 10 2023
medline: 24 10 2023
entrez: 24 10 2023
Statut: epublish

Résumé

Targeted protein degradation by the ubiquitin-proteasome system is an essential mechanism regulating cellular division. The kinase PLK1 coordinates protein degradation at the G2/M phase of the cell cycle by promoting the binding of substrates to the E3 ubiquitin ligase SCF

Identifiants

DOI: 10.1101/2023.10.11.561963 PMID: 37873169 PMC: PMC10592729
pubmed: 37873169
doi: 10.1101/2023.10.11.561963
pmc: PMC10592729
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIGMS NIH HHS
ID : T32 GM008570
Pays : United States
Organisme : NCI NIH HHS
ID : F31 CA189328
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016086
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM120309
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA071341
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM128855
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM134231
Pays : United States

Déclaration de conflit d'intérêts

Competing Interest Statement Authors declare no competing interests.

Auteurs

Ryan D Mouery (RD)

Curriculum in Genetics and Molecular Biology. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.

Carolyn Hsu (C)

Lineberger Comprehensive Cancer Center. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.

Thomas Bonacci (T)

Lineberger Comprehensive Cancer Center. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.
Department of Pharmacology. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.

Derek L Bolhuis (DL)

Department of Biochemistry and Biophysics. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.

Xianxi Wang (X)

Lineberger Comprehensive Cancer Center. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.
Department of Pharmacology. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.

Christine A Mills (CA)

UNC Proteomics Core Facility, Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

E Drew Toomer (ED)

Lineberger Comprehensive Cancer Center. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.
Department of Pharmacology. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.

Owen G Canterbury (OG)

Department of Pharmacology. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.

Kevin C Robertson (KC)

Lineberger Comprehensive Cancer Center. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.
Department of Pharmacology. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.

Timothy B Branigan (TB)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

Nicholas G Brown (NG)

Lineberger Comprehensive Cancer Center. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.
Department of Pharmacology. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.

Laura E Herring (LE)

Lineberger Comprehensive Cancer Center. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.
Department of Pharmacology. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.
UNC Proteomics Core Facility, Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Michael J Emanuele (MJ)

Lineberger Comprehensive Cancer Center. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.
Department of Pharmacology. The University of North Carolina at Chapel Hill. Chapel Hill, NC 27599, USA.

Classifications MeSH