Regulation of astrocyte metabolism by mitochondrial translocator protein 18kDa.
TSPO
astrocyte
cytokine release
fatty acid oxidation
inflammation
metabolism
translocator protein 18kDa
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
02 Oct 2023
02 Oct 2023
Historique:
pubmed:
24
10
2023
medline:
24
10
2023
entrez:
24
10
2023
Statut:
epublish
Résumé
The mitochondrial translocator protein 18kDa (TSPO) has been linked to a variety of functions from steroidogenesis to regulation of cellular metabolism and is an attractive therapeutic target for chronic CNS inflammation. Studies in the periphery using Leydig cells and hepatocytes, as well as work in microglia, indicate that the function of TSPO may vary between cells depending on their specialised roles. Astrocytes are critical for providing trophic and metabolic support in the brain as part of their role in maintaining brain homeostasis. Recent work has highlighted that TSPO expression increases in astrocytes under inflamed conditions and may drive astrocyte reactivity. However, relatively little is known about the role TSPO plays in regulating astrocyte metabolism and whether this protein is involved in immunometabolic processes in these cells. Using TSPO-deficient (TSPO
Identifiants
pubmed: 37873215
doi: 10.1101/2023.09.29.560159
pmc: PMC10592862
pii:
doi:
Types de publication
Preprint
Langues
eng
Déclaration de conflit d'intérêts
Conflict of interest: The authors declare no conflicts of interest.
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