WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
11 Oct 2023
11 Oct 2023
Historique:
medline:
24
10
2023
pubmed:
24
10
2023
entrez:
24
10
2023
Statut:
epublish
Résumé
Pathogenic brain aging and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease are characterized by chronic neuroinflammation and the accumulation of dysfunctional or misfolded proteins that lead to progressive neuronal cell death. Here we demonstrate that a murine model with global loss of the CUL4-DDB1 substrate receptor WDR23 ( WDR23 regulates NRF2/NFE2L2 stability in the mouse hippocampus Loss of
Identifiants
pubmed: 37873429
doi: 10.1101/2023.10.10.561805
pmc: PMC10592735
pii:
doi:
Types de publication
Preprint
Langues
eng