Connective tissue growth factor: Role in trabecular meshwork remodeling and intraocular pressure lowering.
Antiglaucoma
CTGF
TGF-β
extracellular matrix
fibrosis
remodeling
Journal
Experimental biology and medicine (Maywood, N.J.)
ISSN: 1535-3699
Titre abrégé: Exp Biol Med (Maywood)
Pays: England
ID NLM: 100973463
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
pmc-release:
24
04
2024
medline:
20
11
2023
pubmed:
24
10
2023
entrez:
24
10
2023
Statut:
ppublish
Résumé
Connective tissue growth factor (CTGF) is a distinct signaling molecule modulating many physiological and pathophysiological processes. This protein is upregulated in numerous fibrotic diseases that involve extracellular matrix (ECM) remodeling. It mediates the downstream effects of transforming growth factor beta (TGF-β) and is regulated via TGF-β SMAD-dependent and SMAD-independent signaling routes. Targeting CTGF instead of its upstream regulator TGF-β avoids the consequences of interfering with the pleotropic effects of TGF-β. Both CTGF and its upstream mediator, TGF-β, have been linked with the pathophysiology of glaucomatous optic neuropathy due to their involvement in the regulation of ECM homeostasis. The excessive expression of these growth factors is associated with glaucoma pathogenesis via elevation of the intraocular pressure (IOP), the most important risk factor for glaucoma. The raised in the IOP is due to dysregulation of ECM turnover resulting in excessive ECM deposition at the site of aqueous humor outflow. It is therefore believed that CTGF could be a potential therapeutic target in glaucoma therapy. This review highlights the CTGF biology and structure, its regulation and signaling, its association with the pathophysiology of glaucoma, and its potential role as a therapeutic target in glaucoma management.
Identifiants
pubmed: 37873757
doi: 10.1177/15353702231199466
pmc: PMC10657592
doi:
Substances chimiques
Transforming Growth Factor beta
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1425-1436Déclaration de conflit d'intérêts
Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Références
PLoS One. 2014 May 02;9(5):e96365
pubmed: 24788939
Biochim Biophys Acta. 2007 Apr;1770(4):672-80
pubmed: 17239539
Exp Ther Med. 2020 Mar;19(3):2291-2295
pubmed: 32104296
Expert Opin Investig Drugs. 2020 Aug;29(8):771-777
pubmed: 32447983
J Bone Miner Res. 2011 Jan;26(1):193-208
pubmed: 20684029
PLoS One. 2015 Dec 31;10(12):e0146159
pubmed: 26719893
Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1903-10
pubmed: 19011018
Int J Mol Sci. 2018 Nov 20;19(11):
pubmed: 30463366
Mol Biol Cell. 2012 May;23(10):1976-85
pubmed: 22438586
Exp Eye Res. 2009 Apr;88(4):683-8
pubmed: 19385040
BioDrugs. 2007;21(3):167-77
pubmed: 17516712
Exp Eye Res. 2017 May;158:137-145
pubmed: 27453344
Graefes Arch Clin Exp Ophthalmol. 2004 Feb;242(2):165-171
pubmed: 14648133
Eur J Cell Biol. 2013 Oct-Nov;92(10-11):303-15
pubmed: 24183240
Cell Signal. 2021 Jul;83:109978
pubmed: 33722671
Biochem Pharmacol. 2018 Sep;155:71-81
pubmed: 29909077
Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2588-96
pubmed: 12766061
Cell Tissue Res. 2020 Mar;379(3):549-559
pubmed: 31773302
Graefes Arch Clin Exp Ophthalmol. 2001 Feb;239(2):109-13
pubmed: 11372538
Int J Ophthalmol. 2013;6(1):8-14
pubmed: 23550216
Mini Rev Med Chem. 2010 Jun;10(7):578-95
pubmed: 20500149
Am J Physiol Cell Physiol. 2018 Apr 1;314(4):C415-C427
pubmed: 29351412
BMC Med Genomics. 2010 Oct 04;3:44
pubmed: 20920318
mBio. 2017 Jan 3;8(1):
pubmed: 28049150
Kidney Int. 2002 Aug;62(2):401-11
pubmed: 12110001
Clin J Am Soc Nephrol. 2010 Aug;5(8):1420-8
pubmed: 20522536
Growth Factors. 2008 Apr;26(2):80-91
pubmed: 18428027
Int J Mol Sci. 2021 Mar 14;22(6):
pubmed: 33799469
J Biol Chem. 2011 Jul 8;286(27):24242-52
pubmed: 21454550
Nature. 2008 Apr 3;452(7187):591-7
pubmed: 18368052
Cardiovasc Res. 1998 Jun;38(3):802-13
pubmed: 9747449
J Mol Cell Cardiol. 2015 Dec;89(Pt B):214-22
pubmed: 26549358
Acta Ophthalmol. 2010 Sep;88(6):652-9
pubmed: 20039857
Mol Ther. 2012 Jan;20(1):101-8
pubmed: 21988875
J Cell Commun Signal. 2013 Dec;7(4):253-63
pubmed: 23740088
Exp Eye Res. 2021 Jul;208:108622
pubmed: 34022176
Biomed Pharmacother. 2019 Mar;111:1429-1437
pubmed: 30841458
Front Cell Dev Biol. 2020 Oct 29;8:593269
pubmed: 33195264
Ophthalmic Res. 2001 Nov-Dec;33(6):314-24
pubmed: 11721183
Eur J Pharmacol. 2018 Mar 5;822:199-206
pubmed: 29374548
Matrix Biol. 2015 Apr;43:71-84
pubmed: 25779637
J Cell Biol. 1991 Sep;114(6):1285-94
pubmed: 1654338
Mol Biol Cell. 2001 Jan;12(1):27-36
pubmed: 11160820
Endocrinology. 2011 Nov;152(11):4232-41
pubmed: 21914781
Int Ophthalmol. 2004 Jan;25(1):19-22
pubmed: 15085971
Cell. 2003 Jun 13;113(6):685-700
pubmed: 12809600
Small. 2018 Dec;14(50):e1803239
pubmed: 30353713
Nat Cell Biol. 2002 Aug;4(8):599-604
pubmed: 12134160
J Korean Med Sci. 2004 Dec;19(6):805-11
pubmed: 15608389
Dev Dyn. 2008 Feb;237(2):485-93
pubmed: 18213577
J Cell Physiol. 2008 May;215(2):410-21
pubmed: 18064627
J Exp Med. 2017 Mar 6;214(3):681-697
pubmed: 28183733
Int J Mol Med. 2016 Aug;38(2):391-8
pubmed: 27279555
Microbes Infect. 1999 Dec;1(15):1265-73
pubmed: 10611754
Acta Ophthalmol Scand. 2003 Feb;81(1):51-3
pubmed: 12631020
J Cell Physiol. 2002 Apr;191(1):1-16
pubmed: 11920677
FASEB J. 2007 Oct;21(12):3355-68
pubmed: 17554073
Methods Mol Biol. 2023;2582:1-10
pubmed: 36370338
Cell Signal. 2013 Oct;25(10):1981-92
pubmed: 23727026
Invest Ophthalmol Vis Sci. 2014 Apr 01;55(4):2062-70
pubmed: 24627144
Exp Dermatol. 2019 Jan;28(1):11-18
pubmed: 30329180
Exp Eye Res. 2017 May;158:23-32
pubmed: 27593914
J Biomed Sci. 2018 Mar 2;25(1):19
pubmed: 29499695
Adv Exp Med Biol. 2019;1165:365-380
pubmed: 31399974
Prog Retin Eye Res. 2013 Nov;37:1-12
pubmed: 23770081
Front Cell Dev Biol. 2022 Mar 01;10:844342
pubmed: 35300422
PLoS One. 2012;7(9):e45430
pubmed: 23029004
PLoS One. 2015 Sep 04;10(9):e0136712
pubmed: 26340021
J Cell Sci. 2006 Dec 1;119(Pt 23):4803-10
pubmed: 17130294
Cold Spring Harb Perspect Biol. 2017 Jan 3;9(1):
pubmed: 27836834
J Biol Chem. 2002 Sep 27;277(39):36288-95
pubmed: 12114504
Drugs. 2014 Dec;74(18):2211-5
pubmed: 25414122
Br J Pharmacol. 2013 Oct;170(4):730-47
pubmed: 23937539
Biomed Res Int. 2017;2017:5712341
pubmed: 28210622
Graefes Arch Clin Exp Ophthalmol. 2001 Mar;239(3):199-207
pubmed: 11405069
Dev Growth Differ. 2009 Jan;51(1):55-67
pubmed: 19128405
Mol Pathol. 2003 Apr;56(2):127-8
pubmed: 12665631
Bone. 2006 May;38(5):671-7
pubmed: 16311085
Invest Ophthalmol Vis Sci. 2002 Nov;43(11):3465-72
pubmed: 12407157
FEBS Lett. 1993 Jul 26;327(2):125-30
pubmed: 7687569
Exp Eye Res. 2009 Jun;88(6):1065-75
pubmed: 19450452
Acta Neuropathol. 2016 Dec;132(6):807-826
pubmed: 27544758
Expert Opin Biol Ther. 2003 Feb;3(1):45-56
pubmed: 12718730
Int J Biochem Cell Biol. 2010 May;42(5):585-9
pubmed: 20060931
Exp Cell Res. 2012 Oct 1;318(16):2105-15
pubmed: 22749815
Matrix Biol. 2022 May;109:121-139
pubmed: 35385768
J BUON. 2016 Nov-Dec;21(6):1359-1367
pubmed: 28039692
BMB Rep. 2018 Oct;51(10):486-492
pubmed: 30158025
Exp Eye Res. 2003 Dec;77(6):757-65
pubmed: 14609564
Ther Deliv. 2011 Nov;2(11):1395-406
pubmed: 22826872
Cell Tissue Res. 2003 May;312(2):175-88
pubmed: 12712324
Invest Ophthalmol Vis Sci. 2014 Apr 09;55(4):2276-83
pubmed: 24627146
EMBO J. 2001 Feb 15;20(4):755-66
pubmed: 11179220
Mol Vis. 2015 May 25;21:612-20
pubmed: 26019480
J Biol Chem. 2013 May 3;288(18):12654-66
pubmed: 23530034
Am J Pathol. 2012 Jun;180(6):2386-403
pubmed: 22542845
Invest Ophthalmol Vis Sci. 2007 Feb;48(2):715-26
pubmed: 17251470
Dev Dyn. 2012 Dec;241(12):1944-59
pubmed: 23073844
Physiol Rev. 2014 Oct;94(4):1287-312
pubmed: 25287865
Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L344-57
pubmed: 25502501
FASEB J. 2012 Aug;26(8):3365-79
pubmed: 22611085
Matrix Biol. 2020 May;87:48-65
pubmed: 31669521
J Biol Chem. 2001 Dec 14;276(50):46707-13
pubmed: 11590169
Invest Ophthalmol Vis Sci. 2012 Jun 05;53(7):3387-94
pubmed: 22511630
Biomol Concepts. 2013 Oct;4(5):477-94
pubmed: 25436754
Gastroenterology. 2005 Sep;129(3):1019-30
pubmed: 16143139
Pharmazie. 2020 May 1;75(5):213-217
pubmed: 32393432
Inflamm Regen. 2018 Aug 06;38:14
pubmed: 30123390
JAMA. 2014 May 14;311(18):1901-11
pubmed: 24825645
Mol Cell. 2008 Sep 26;31(6):918-24
pubmed: 18922473
Drugs. 2018 Mar;78(3):389-396
pubmed: 29453668
J Biol Chem. 2004 Mar 5;279(10):8848-55
pubmed: 14684735
J Cell Mol Med. 2020 May;24(9):5195-5204
pubmed: 32267082
Am J Physiol Cell Physiol. 2008 Nov;295(5):C1057-70
pubmed: 18799648
Clin Exp Immunol. 2006 Nov;146(2):362-70
pubmed: 17034590
J Biol Chem. 2001 Apr 6;276(14):10594-601
pubmed: 11152469
Cell Tissue Res. 2012 Jan;347(1):11-20
pubmed: 21701805
Br J Ophthalmol. 2004 Aug;88(8):1082-7
pubmed: 15258030
Exp Eye Res. 2017 May;158:3-12
pubmed: 27448987
Reprod Sci. 2016 Mar;23(3):386-94
pubmed: 26392347
PLoS One. 2012;7(9):e45079
pubmed: 23028770
PLoS One. 2016 Sep 01;11(9):e0161332
pubmed: 27584577
Arthritis Rheum. 2009 Jul;60(7):2142-55
pubmed: 19565505
Biochem J. 2012 Jan 1;441(1):499-510
pubmed: 21871016
Am J Ophthalmol. 2019 Jun;202:126-132
pubmed: 30794789
Cell. 2005 Aug 12;122(3):421-34
pubmed: 16096061
Eur J Pharm Sci. 2014 Jul 16;58:13-9
pubmed: 24613900
Clin Pharmacokinet. 2010 Aug;49(8):493-507
pubmed: 20608753
PLoS One. 2015 May 08;10(5):e0126532
pubmed: 25955392
J Leukoc Biol. 2013 Jan;93(1):101-12
pubmed: 23108098
Am J Physiol Cell Physiol. 2009 Dec;297(6):C1490-500
pubmed: 19625611
Am J Physiol Cell Physiol. 2013 Feb 1;304(3):C216-25
pubmed: 23255577
Invest Ophthalmol Vis Sci. 2004 Feb;45(2):485-91
pubmed: 14744889
Oncotarget. 2014 Jun 15;5(11):3800-12
pubmed: 25003330
J Am Soc Nephrol. 2000 Jan;11(1):25-38
pubmed: 10616837
Biochimie. 2011 Mar;93(3):377-88
pubmed: 21130134
Front Physiol. 2017 Oct 24;8:829
pubmed: 29114233
Br J Ophthalmol. 2016 Jan;100(1):86-93
pubmed: 26286821
Int J Mol Sci. 2020 Nov 29;21(23):
pubmed: 33260349
Mol Ther. 2008 Jan;16(1):107-14
pubmed: 17923842
Ophthalmology. 2016 Jan;123(1):129-40
pubmed: 26526633
Invest Ophthalmol Vis Sci. 2010 Aug;51(8):4060-6
pubmed: 20237246
Cold Spring Harb Perspect Biol. 2017 Feb 1;9(2):
pubmed: 27864313
Arch Ophthalmol. 2003 Sep;121(9):1283-8
pubmed: 12963611
Cancer Res. 2018 Sep 1;78(17):4902-4914
pubmed: 29967264
Invest Ophthalmol Vis Sci. 2001 Jan;42(1):137-44
pubmed: 11133858
Curr Eye Res. 2016 Dec;41(12):1571-1579
pubmed: 27337054
FASEB J. 2019 Nov;33(11):12554-12564
pubmed: 31451010
Sci Rep. 2017 Jan 16;7:40717
pubmed: 28091584
PLoS One. 2015 Mar 23;10(3):e0120774
pubmed: 25799097
Respir Res. 2021 Apr 1;22(1):97
pubmed: 33794877
PLoS One. 2015 Nov 24;10(11):e0143514
pubmed: 26599235
Pharm Res. 2016 Aug;33(8):1833-49
pubmed: 27059922
Curr Biol. 2007 Dec 4;17(23):2054-60
pubmed: 17980593
Prog Retin Eye Res. 1999 Jan;18(1):91-119
pubmed: 9920500
PLoS One. 2015 Aug 04;10(8):e0133689
pubmed: 26241738
J Cell Commun Signal. 2012 Dec;6(4):225-32
pubmed: 22956334
Invest Ophthalmol Vis Sci. 2011 Jun 01;52(6):3660-6
pubmed: 21330667
Exp Eye Res. 2009 Apr;88(4):713-7
pubmed: 18793636
Eye (Lond). 2020 Dec;34(12):2163-2174
pubmed: 32587389
Nat Rev Drug Discov. 2011 Dec 01;10(12):945-63
pubmed: 22129992
Invest Ophthalmol Vis Sci. 2013 Dec 02;54(13):7836-48
pubmed: 24204045
J Cell Commun Signal. 2013 Aug;7(3):169-77
pubmed: 23420091
J Orthop Res. 2012 Nov;30(11):1738-45
pubmed: 22576977
J Clin Invest. 2001 May;107(9):1049-54
pubmed: 11342565
Mol Vis. 2006 Sep 30;12:1117-26
pubmed: 17093396
J Cell Commun Signal. 2009 Mar;3(1):5-18
pubmed: 19294531
Ophthalmic Res. 2002 Sep-Oct;34(5):306-8
pubmed: 12381892
Hum Mol Genet. 2013 Dec 15;22(24):4938-51
pubmed: 23904456
Nat Cell Biol. 2008 Oct;10(10):1199-207
pubmed: 18758450
Trends Biochem Sci. 2008 Oct;33(10):461-73
pubmed: 18789696
J Cell Sci. 2021 Jun 1;134(11):
pubmed: 34096606
Clin Chim Acta. 2011 Nov 20;412(23-24):2211-5
pubmed: 21864521