Changes in Hematological and Hemorheological Parameters Following Mild COVID-19: A 4-Month Follow-Up Study.
COVID-19
hemoglobin
red blood cell aggregation
red blood cell deformability
red blood cells
Journal
Hematology reports
ISSN: 2038-8322
Titre abrégé: Hematol Rep
Pays: Switzerland
ID NLM: 101556723
Informations de publication
Date de publication:
10 Oct 2023
10 Oct 2023
Historique:
received:
29
06
2023
revised:
14
08
2023
accepted:
08
10
2023
medline:
24
10
2023
pubmed:
24
10
2023
entrez:
24
10
2023
Statut:
epublish
Résumé
Coronavirus Disease 2019 (COVID-19) was described to affect red blood cells (RBC) in both severe and mild disease courses. The aim of this study was to investigate whether hematological and hemorheological changes that were previously described for COVID-19 patients after the acute infection state are still prominent after another 4 months to assess potential long-term effects. Hematological and RBC rheological parameters, including deformability and aggregation, were measured 41 days after infection in COVID-19 patients and non-COVID control (T0) and 4 months later in COVID-19 patients (T1). The data confirm alterations in hematological parameters, mainly related to cell volume and hemoglobin concentration, but also reduced deformability and increased aggregation at T0 compared to control. While RBC deformability seems to have recovered, hemoglobin-related parameters and RBC aggregation were still impaired at T1. The changes were thus more pronounced in male COVID-19 patients. COVID-19-related changes of the RBC partly consist of several months and might be related to persistent symptoms reported by many COVID-19 patients.
Sections du résumé
BACKGROUND
BACKGROUND
Coronavirus Disease 2019 (COVID-19) was described to affect red blood cells (RBC) in both severe and mild disease courses. The aim of this study was to investigate whether hematological and hemorheological changes that were previously described for COVID-19 patients after the acute infection state are still prominent after another 4 months to assess potential long-term effects.
METHODS
METHODS
Hematological and RBC rheological parameters, including deformability and aggregation, were measured 41 days after infection in COVID-19 patients and non-COVID control (T0) and 4 months later in COVID-19 patients (T1).
RESULTS
RESULTS
The data confirm alterations in hematological parameters, mainly related to cell volume and hemoglobin concentration, but also reduced deformability and increased aggregation at T0 compared to control. While RBC deformability seems to have recovered, hemoglobin-related parameters and RBC aggregation were still impaired at T1. The changes were thus more pronounced in male COVID-19 patients.
CONCLUSION
CONCLUSIONS
COVID-19-related changes of the RBC partly consist of several months and might be related to persistent symptoms reported by many COVID-19 patients.
Identifiants
pubmed: 37873792
pii: hematolrep15040057
doi: 10.3390/hematolrep15040057
pmc: PMC10594454
doi:
Types de publication
Journal Article
Langues
eng
Pagination
543-554Subventions
Organisme : Bundesinstitut für Sportwissenschaft
ID : FKZ 2521BI0106
Références
Einstein (Sao Paulo). 2021 Apr 16;19:eCE6285
pubmed: 33886935
J Proteome Res. 2020 Nov 6;19(11):4455-4469
pubmed: 33103907
Front Physiol. 2018 Dec 19;9:1835
pubmed: 30618840
Int J Hematol. 2020 Oct;112(4):553-559
pubmed: 32656638
Int J Mol Sci. 2022 Feb 16;23(4):
pubmed: 35216286
Blood Cells Mol Dis. 2016 Jan;56(1):9-22
pubmed: 26603718
Cureus. 2021 Feb 18;13(2):e13416
pubmed: 33758711
Semin Thromb Hemost. 2003 Oct;29(5):435-50
pubmed: 14631543
Front Physiol. 2022 Feb 28;13:849910
pubmed: 35295564
Am J Hematol. 2022 Mar 1;97(3):283-292
pubmed: 34939698
Diagnostics (Basel). 2020 Aug 21;10(9):
pubmed: 32825629
Front Physiol. 2022 Jul 04;13:932013
pubmed: 35860651
Scand J Clin Lab Invest. 2015 May;75(3):213-22
pubmed: 25594795
Int J Sports Med. 2018 Jan;39(1):12-20
pubmed: 29165733
Braz J Med Biol Res. 2022 Jul 13;55:e12118
pubmed: 35857999
Clin Hemorheol Microcirc. 2007;36(4):319-26
pubmed: 17502702
Br J Haematol. 2021 Feb;192(4):e108-e111
pubmed: 33410504
Front Physiol. 2017 Dec 05;8:979
pubmed: 29259557
Int J Mol Sci. 2022 Dec 05;23(23):
pubmed: 36499657
Biophys J. 2021 Jul 20;120(14):2838-2847
pubmed: 34087216
J Thromb Haemost. 2020 Aug;18(8):1849-1852
pubmed: 32588535
Clin Hemorheol Microcirc. 2001;25(1):1-11
pubmed: 11790865
J Cell Mol Med. 2022 May;26(10):3022-3030
pubmed: 35419946
Front Physiol. 2013 Nov 12;4:332
pubmed: 24273518
Front Physiol. 2021 Sep 22;12:722896
pubmed: 34690797
Front Physiol. 2017 Dec 12;8:1043
pubmed: 29311973
J Gend Specif Med. 2001;4(1):35-40
pubmed: 11324238
Prog Cardiovasc Dis. 2021 Jul-Aug;67:35-39
pubmed: 33964290
Front Physiol. 2018 Apr 27;9:451
pubmed: 29755372
Clin Hemorheol Microcirc. 1998 Dec;19(4):315-25
pubmed: 9972669
Angiogenesis. 2021 Feb;24(1):145-157
pubmed: 33058027
Am J Physiol. 1999 Dec;277(6):H2145-57
pubmed: 10600832
Front Med (Lausanne). 2023 Feb 27;10:1098547
pubmed: 36923010
Sports Med. 2023 Jan;53(1):51-74
pubmed: 36115933
Clin Hemorheol Microcirc. 1999;21(3-4):357-63
pubmed: 10711771
Front Immunol. 2017 Feb 02;8:73
pubmed: 28210260
Clin Hemorheol Microcirc. 2016;62(1):45-54
pubmed: 26410854