The ErbB Signaling Network and Its Potential Role in Endometrial Cancer.
EGF system
ErbB receptors
carcinogenesis
clinical role
endometrial cancer
expression profile
physiology
signaling pathways
Journal
Epigenomes
ISSN: 2075-4655
Titre abrégé: Epigenomes
Pays: Switzerland
ID NLM: 101736595
Informations de publication
Date de publication:
01 Oct 2023
01 Oct 2023
Historique:
received:
17
08
2023
revised:
24
09
2023
accepted:
26
09
2023
medline:
24
10
2023
pubmed:
24
10
2023
entrez:
24
10
2023
Statut:
epublish
Résumé
Endometrial cancer (EC) is the second most common malignancy of the female reproductive system worldwide. The updated EC classification emphasizes the significant role of various signaling pathways such as PIK3CA-PIK3R1-PTEN and RTK/RAS/β-catenin in EC pathogenesis. Some of these pathways are part of the EGF system signaling network, which becomes hyperactivated by various mechanisms and participates in cancer pathogenesis. In EC, the expression of ErbB receptors is significantly different, compared with the premenopausal and postmenopausal endometrium, mainly because of the increased transcriptional activity of ErbB encoding genes in EC cells. Moreover, there are some differences in ErbB-2 receptor profile among EC subgroups that could be explained by the alterations in pathophysiology and clinical behavior of various EC histologic subtypes. The fact that ErbB-2 receptor expression is more common in aggressive EC histologic subtypes (papillary serous and clear cell) could indicate a future role of ErbB-targeted therapies in well-defined EC subgroups with overexpression of ErbB receptors.
Identifiants
pubmed: 37873809
pii: epigenomes7040024
doi: 10.3390/epigenomes7040024
pmc: PMC10594534
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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