A feasibility study on exhaled breath analysis using UV spectroscopy to detect COVID-19.
COVID-19
UV spectroscopy
VOC
diagnosis
exhaled breath
preconcentration
Journal
Journal of breath research
ISSN: 1752-7163
Titre abrégé: J Breath Res
Pays: England
ID NLM: 101463871
Informations de publication
Date de publication:
02 Nov 2023
02 Nov 2023
Historique:
received:
28
04
2023
accepted:
24
10
2023
medline:
3
11
2023
pubmed:
25
10
2023
entrez:
24
10
2023
Statut:
epublish
Résumé
A 23-subject feasibility study is reported to assess how UV absorbance measurements on exhaled breath samples collected from silicon microreactors can be used to detect COVID-19. The silicon microreactor technology chemoselectively preconcentrates exhaled carbonyl volatile organic compounds and subsequent methanol elution provides samples for analysis. The underlying scientific rationale that viral infection will induce an increase in exhaled carbonyls appears to be supported by the results of the feasibility study. The data indicate statistically significant differences in measured UV absorbance values between healthy and symptomatic COVID-19 positive subjects in the wavelength range from 235 nm to 305 nm. Factors such as subject age were noted as potential confounding variables.
Identifiants
pubmed: 37875100
doi: 10.1088/1752-7163/ad0646
pmc: PMC10620812
doi:
Substances chimiques
Silicon
Z4152N8IUI
Volatile Organic Compounds
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Creative Commons Attribution license.
Références
Clin Interv Aging. 2018 Apr 26;13:757-772
pubmed: 29731617
Angew Chem Int Ed Engl. 2015 Sep 14;54(38):11036-48
pubmed: 26235374
Protein J. 2020 Dec;39(6):644-656
pubmed: 33106987
Lung Cancer. 2015 Oct;90(1):92-7
pubmed: 26233567
Alcohol. 1990 Jul-Aug;7(4):285-7
pubmed: 2390202
Virol J. 2022 Sep 22;19(1):152
pubmed: 36138463
Diseases. 2021 Feb 24;9(1):
pubmed: 33668325
Obesity (Silver Spring). 2015 Dec;23(12):2327-34
pubmed: 26524104
J Breath Res. 2021 Oct 22;15(4):
pubmed: 34624875
J Breath Res. 2012 Sep;6(3):036008
pubmed: 22932429
Annu Rev Anal Chem (Palo Alto Calif). 2014;7:455-82
pubmed: 25014347
Biomed Chromatogr. 2007 Jun;21(6):553-66
pubmed: 17431933
Chembiochem. 2014 May 5;15(7):1040-8
pubmed: 24719290
Metabolites. 2022 Jun 18;12(6):
pubmed: 35736492
Analyst. 2011 Nov 21;136(22):4662-6
pubmed: 21897949
Commun Med (Lond). 2022 Dec 8;2(1):158
pubmed: 36482179
Nat Rev Microbiol. 2022 May;20(5):270-284
pubmed: 35354968
J Breath Res. 2015 Jan 29;9(2):027101
pubmed: 25634546
Antioxidants (Basel). 2023 Mar 06;12(3):
pubmed: 36978899
EBioMedicine. 2021 Jan;63:103154
pubmed: 33279860
Arch Med Res. 2020 Jul;51(5):384-387
pubmed: 32402576
EClinicalMedicine. 2021 Dec;42:101207
pubmed: 34841237
Molecules. 2020 May 09;25(9):
pubmed: 32397389
J Thorac Cardiovasc Surg. 2014 Sep;148(3):1074-80; discussion 1080-1
pubmed: 25129599
JAMA Netw Open. 2023 Feb 1;6(2):e230982
pubmed: 36853606
Anal Chem. 2023 Mar 7;95(9):4344-4352
pubmed: 36815760
Metabolites. 2019 Mar 18;9(3):
pubmed: 30889835
Biosensors (Basel). 2023 Jan 20;13(2):
pubmed: 36831932
EClinicalMedicine. 2020 Dec;29:100609
pubmed: 33134902
JAMA Oncol. 2019 Jan 1;5(1):e182815
pubmed: 30128487
Tetrahedron Lett. 2010;51(13):1727-1729
pubmed: 20204160
ACS Infect Dis. 2021 Sep 10;7(9):2596-2603
pubmed: 34319698
Sensors (Basel). 2016 Dec 05;16(12):
pubmed: 27929387
Anal Chem. 2012 Feb 7;84(3):1288-93
pubmed: 22145792
J Breath Res. 2018 Jul 30;12(4):046003
pubmed: 29984709
Allergy. 2013 Aug;68(8):1050-6
pubmed: 23888905
Biomark Insights. 2022 May 23;17:11772719221100709
pubmed: 35645556
Clin Chim Acta. 2004 Sep;347(1-2):25-39
pubmed: 15313139
Molecules. 2022 Aug 17;27(16):
pubmed: 36014494
Chem Rev. 2012 Nov 14;112(11):5949-66
pubmed: 22991938