Formyl-peptide receptor 2 signalling triggers aerobic metabolism of glucose through Nox2-dependent modulation of pyruvate dehydrogenase activity.
NADPH oxidase
Warburg effect
formyl peptide receptors
glucose metabolism
reactive oxygen species
tyrosine kinase receptor transactivation
Journal
Open biology
ISSN: 2046-2441
Titre abrégé: Open Biol
Pays: England
ID NLM: 101580419
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
medline:
26
10
2023
pubmed:
25
10
2023
entrez:
24
10
2023
Statut:
ppublish
Résumé
The human formyl-peptide receptor 2 (FPR2) is activated by an array of ligands. By phospho-proteomic analysis we proved that FPR2 stimulation induces redox-regulated phosphorylation of many proteins involved in cellular metabolic processes. In this study, we investigated metabolic pathways activated in FPR2-stimulated CaLu-6 cells. The results showed an increased concentration of metabolites involved in glucose metabolism, and an enhanced uptake of glucose mediated by GLUT4, the insulin-regulated member of GLUT family. Accordingly, we observed that FPR2 transactivated IGF-IR
Identifiants
pubmed: 37875162
doi: 10.1098/rsob.230336
pmc: PMC10597678
doi:
Substances chimiques
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Glucose
IY9XDZ35W2
Phosphatidylinositol 3-Kinases
EC 2.7.1.-
Oxidoreductases
EC 1.-
PFKFB2 protein, human
EC 2.7.1.105
Phosphofructokinase-2
EC 2.7.1.105
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
230336Références
Int J Oncol. 2010 Dec;37(6):1483-93
pubmed: 21042717
Free Radic Biol Med. 2018 Mar;117:76-89
pubmed: 29373843
Arch Biochem Biophys. 2016 Aug 1;603:10-9
pubmed: 27177968
J Pharmacol Exp Ther. 2002 Dec;303(3):909-18
pubmed: 12438509
J Immunol. 2009 Sep 15;183(6):3761-9
pubmed: 19692643
Biochim Biophys Acta. 2013 Dec;1833(12):3481-3498
pubmed: 23830918
Clin Cancer Res. 2009 Nov 1;15(21):6479-83
pubmed: 19861459
Nat Neurosci. 2008 Dec;11(12):1402-9
pubmed: 18953346
Biochem Biophys Res Commun. 2000 Dec 29;279(3):955-60
pubmed: 11162456
J Neurosci. 2010 Jan 13;30(2):749-59
pubmed: 20071540
Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18232-7
pubmed: 24108355
Oncotarget. 2016 Oct 25;7(43):70898-70911
pubmed: 27765922
J Biol Chem. 2011 Feb 25;286(8):6092-9
pubmed: 21212273
Cancer Lett. 2001 Aug 10;169(1):27-32
pubmed: 11410322
Metabolism. 2016 Feb;65(2):124-39
pubmed: 26773935
Free Radic Biol Med. 2004 Jan 15;36(2):189-200
pubmed: 14744631
Int J Mol Sci. 2020 May 27;21(11):
pubmed: 32471307
Mol Cell Biochem. 2020 Jul;470(1-2):115-129
pubmed: 32415418
Biochem Biophys Res Commun. 2015 Jan 2;456(1):489-93
pubmed: 25485703
J Leukoc Biol. 2015 Dec;98(6):923-9
pubmed: 26130702
Mol Biol Cell. 2010 Jun 15;21(12):2087-96
pubmed: 20427574
Cancer Res. 2014 Sep 15;74(18):5301-10
pubmed: 24928781
J Biol Chem. 2000 Jul 21;275(29):21797-800
pubmed: 10823814
Cells. 2020 Jun 26;9(6):
pubmed: 32604782
Cancer Res. 2013 Feb 15;73(4):1298-307
pubmed: 23393200
Open Biol. 2023 Oct;13(10):230336
pubmed: 37875162
Cell Metab. 2010 Apr 7;11(4):311-9
pubmed: 20374963
Wiley Interdiscip Rev Dev Biol. 2015 May-Jun;4(3):215-66
pubmed: 25772309
Sci Rep. 2019 Nov 29;9(1):17894
pubmed: 31784636
Annu Rev Cell Dev Biol. 2011;27:441-64
pubmed: 21985671
FEBS Lett. 2003 Nov 20;554(3):264-70
pubmed: 14623077
Cancer Res. 2011 Dec 1;71(23):7312-22
pubmed: 21937681
Oncogene. 2017 Jul 6;36(27):3797-3806
pubmed: 28218905
J Biol Chem. 2004 Jul 9;279(28):28970-8
pubmed: 15123705
Antioxid Redox Signal. 2009 Nov;11(11):2655-71
pubmed: 19558209
Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18121-6
pubmed: 20921387
Gynecol Oncol. 2005 Jul;98(1):11-8
pubmed: 15907336
Curr Opin Struct Biol. 2004 Dec;14(6):679-86
pubmed: 15582391
Sci Rep. 2020 Sep 3;10(1):14531
pubmed: 32884050
Cancer Cell. 2016 Aug 8;30(2):257-272
pubmed: 27505672
Curr Opin Cell Biol. 2005 Apr;17(2):141-9
pubmed: 15780590
Cell Metab. 2008 Jan;7(1):11-20
pubmed: 18177721
Mol Cancer. 2017 Jun 8;16(1):102
pubmed: 28595656
Arch Immunol Ther Exp (Warsz). 2012 Aug;60(4):277-94
pubmed: 22696046
J Biol Chem. 1981 Jul 25;256(14):7090-3
pubmed: 6265437
Nat Rev Cancer. 2008 Jan;8(1):51-6
pubmed: 18046334
J Biol Chem. 1999 Jul 16;274(29):20281-6
pubmed: 10400647
Semin Cell Dev Biol. 2018 Aug;80:50-64
pubmed: 28587975
Nat Commun. 2019 Oct 11;10(1):4623
pubmed: 31604916
Front Pharmacol. 2019 Sep 12;10:998
pubmed: 31572181
Biochem J. 2000 Feb 1;345 Pt 3:543-55
pubmed: 10642513
Science. 2002 May 31;296(5573):1655-7
pubmed: 12040186
Nutrients. 2019 Jan 14;11(1):
pubmed: 30646510
Mol Cancer Ther. 2019 Oct;18(10):1673-1681
pubmed: 31511353
Molecules. 2017 Mar 13;22(3):
pubmed: 28335409
J Cardiovasc Pharmacol. 2017 Jul;70(1):3-9
pubmed: 28059858
Mol Med Rep. 2012 Mar;5(3):599-602
pubmed: 22200795
Int Rev Cell Mol Biol. 2018;339:1-40
pubmed: 29776602
Sci Rep. 2019 May 2;9(1):6815
pubmed: 31048743
Biochim Biophys Acta. 2005 Sep 10;1745(2):166-75
pubmed: 16129124
Antioxidants (Basel). 2022 Aug 29;11(9):
pubmed: 36139766
Biomedicines. 2021 Apr 24;9(5):
pubmed: 33923349
Science. 2009 May 22;324(5930):1029-33
pubmed: 19460998
Adv Biol Regul. 2018 May;68:55-63
pubmed: 29306548
Antioxidants (Basel). 2021 Jan 19;10(1):
pubmed: 33477989
Cell. 1997 May 30;89(5):693-702
pubmed: 9182757
Pigment Cell Melanoma Res. 2014 Jul;27(4):621-9
pubmed: 24628914
Target Oncol. 2017 Aug;12(4):463-474
pubmed: 28589492
Endocr Rev. 2003 Dec;24(6):765-81
pubmed: 14671004
Cell. 2005 Jun 3;121(5):667-70
pubmed: 15935753
Nat Commun. 2019 May 13;10(1):2130
pubmed: 31086178
Clin Cancer Res. 2009 May 1;15(9):3058-67
pubmed: 19383820
EBioMedicine. 2019 Sep;47:65-77
pubmed: 31495720
Trends Biochem Sci. 2003 Sep;28(9):509-14
pubmed: 13678963
Antioxid Redox Signal. 2010 Aug 15;13(4):425-36
pubmed: 20039838
Bioorg Med Chem. 2009 Jul 15;17(14):5146-52
pubmed: 19523836
Am J Physiol. 1998 Mar;274(3):E516-26
pubmed: 9530136
Free Radic Biol Med. 2009 Nov 1;47(9):1239-53
pubmed: 19628035
Mol Cell Biol. 2011 Dec;31(24):4938-50
pubmed: 21969607
Sci Rep. 2016 Mar 16;6:23135
pubmed: 26979487
Blood. 2012 May 17;119(20):4686-97
pubmed: 22452979
Free Radic Biol Med. 2011 Sep 15;51(6):1126-36
pubmed: 21708247
Science. 2010 Dec 3;330(6009):1340-4
pubmed: 21127244
Curr Opin Genet Dev. 2010 Feb;20(1):51-6
pubmed: 19942427
Biochem J. 1997 Oct 15;327 ( Pt 2):369-75
pubmed: 9359403
Cell Signal. 2011 Dec;23(12):1961-71
pubmed: 21777671
Trends Biochem Sci. 2001 Jan;26(1):30-5
pubmed: 11165514
Int J Mol Sci. 2018 Sep 06;19(9):
pubmed: 30200598
Cancer Res. 2004 Apr 1;64(7):2627-33
pubmed: 15059920
Mol Cancer Res. 2020 Jan;18(1):79-90
pubmed: 31641008
Cancer Cell. 2006 Jun;9(6):419-20
pubmed: 16766260
Free Radic Biol Med. 2004 May 15;36(10):1279-88
pubmed: 15110393
Neurochem Res. 2010 Dec;35(12):2018-26
pubmed: 21042851
Mol Cancer Res. 2009 Jun;7(6):907-15
pubmed: 19491199
Cell Death Dis. 2020 Aug 8;11(8):653
pubmed: 32811815
Arch Biochem Biophys. 2009 Jan 1;481(1):94-100
pubmed: 18996352
Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):235-245
pubmed: 27815219
FEBS Lett. 2013 May 21;587(10):1536-42
pubmed: 23583448
Biochem Soc Trans. 2006 Apr;34(Pt 2):217-22
pubmed: 16545080
Front Immunol. 2017 Dec 19;8:1852
pubmed: 29312335
Oxid Med Cell Longev. 2016;2016:6815727
pubmed: 26649143
J Biol Chem. 1995 Dec 8;270(49):29176-81
pubmed: 7493944
Arch Physiol Biochem. 2006 Jul;112(3):139-49
pubmed: 17132539
Oxid Med Cell Longev. 2019 Dec 2;2019:2051235
pubmed: 31871542
J Biol Chem. 2008 Jun 6;283(23):15601-10
pubmed: 18408012
Biochem J. 2004 Aug 1;381(Pt 3):561-79
pubmed: 15170386
EMBO Rep. 2007 Dec;8(12):1162-9
pubmed: 17975556
Br J Pharmacol. 2020 Oct;177(20):4595-4600
pubmed: 32954491
Cell Mol Life Sci. 2007 Apr;64(7-8):830-49
pubmed: 17310282
J Leukoc Biol. 1999 Mar;65(3):337-40
pubmed: 10080536
Nat Rev Cancer. 2011 May;11(5):325-37
pubmed: 21508971
Nat Cell Biol. 2015 Apr;17(4):351-9
pubmed: 25774832
Hypertension. 2018 Mar;71(3):507-517
pubmed: 29335250
Am J Physiol Endocrinol Metab. 2014 May 1;306(9):E1065-76
pubmed: 24619881
Circ Res. 2001 May 25;88(10):1044-52
pubmed: 11375274
Chin J Cancer Res. 2019 Jun;31(3):521-532
pubmed: 31354221
Nat Med. 2002 Nov;8(11):1296-302
pubmed: 12368905
Nat Struct Mol Biol. 2018 Jan;25(1):4-12
pubmed: 29323277
J Biol Chem. 2008 Aug 15;283(33):22700-8
pubmed: 18541534
J Cell Mol Med. 2019 Aug;23(8):5087-5097
pubmed: 31124603
Science. 1995 Oct 13;270(5234):296-9
pubmed: 7569979
Immunology. 2020 May;160(1):78-89
pubmed: 32107769
Int J Oncol. 2011 Aug;39(2):453-63
pubmed: 21617859
Curr Biol. 2018 Oct 22;28(20):3220-3228.e6
pubmed: 30293715
Mol Cell Biol. 1998 Jul;18(7):3966-73
pubmed: 9632781
Exp Mol Med. 2020 Oct;52(10):1694-1704
pubmed: 33082511
J Clin Med. 2019 Dec 05;8(12):
pubmed: 31817415
Int J Mol Sci. 2013 Apr 02;14(4):7193-230
pubmed: 23549262
Free Radic Biol Med. 2010 Jul 15;49(2):130-43
pubmed: 20353819
Cytokine Growth Factor Rev. 2005 Apr;16(2):139-49
pubmed: 15863030
J Biol Chem. 1997 Jan 3;272(1):217-21
pubmed: 8995250
Biochem J. 2010 Oct 15;431(2):267-75
pubmed: 20687898
Neuropharmacology. 2019 Jul 1;152:67-77
pubmed: 30445101
Neuropharmacology. 2020 Jun 15;170:108070
pubmed: 32229140
Cancer Res. 2018 Aug 15;78(16):4459-4470
pubmed: 29891507
Nutrients. 2018 Oct 02;10(10):
pubmed: 30279339
Endocrinology. 2004 Jun;145(6):2978-87
pubmed: 14976148
Am J Hypertens. 2005 Jan;18(1):81-7
pubmed: 15691621
J Immunol. 2013 Jun 15;190(12):6478-87
pubmed: 23686496
Antioxid Redox Signal. 2010 Aug 15;13(4):467-87
pubmed: 20001746
J Neurochem. 2011 Mar;116(5):866-73
pubmed: 21214560
Biomolecules. 2020 Jun 05;10(6):
pubmed: 32517099
Nutrients. 2018 Nov 20;10(11):
pubmed: 30463345
Exp Physiol. 2019 Apr;104(4):447-452
pubmed: 30737851
J Biol Chem. 2014 Aug 1;289(31):21413-22
pubmed: 24962578
Mol Cell. 2011 Dec 23;44(6):864-77
pubmed: 22195962
Int J Mol Sci. 2014 Oct 29;15(11):19700-28
pubmed: 25356505
Proc Natl Acad Sci U S A. 1980 May;77(5):2542-5
pubmed: 6771756
Sci Adv. 2016 May 27;2(5):e1600200
pubmed: 27386546
Oxid Med Cell Longev. 2018 Mar 18;2018:2609847
pubmed: 29743977
J Immunol. 2008 May 1;180(9):6010-7
pubmed: 18424721
J Biol Chem. 2004 Feb 20;279(8):6921-33
pubmed: 14638692
Cancer Cell. 2006 Jun;9(6):425-34
pubmed: 16766262
Ann Diagn Pathol. 2018 Dec;37:62-66
pubmed: 30286327
Curr Opin Endocr Metab Res. 2021 Feb;16:102-112
pubmed: 33748531
Biochim Biophys Acta Mol Cell Res. 2019 Feb;1866(2):305-316
pubmed: 30521870