Urinary Excretion of Mercapturic Acids of the Rodent Carcinogen Methyleugenol after a Single Meal of Basil Pesto: A Controlled Exposure Study in Humans.


Journal

Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448

Informations de publication

Date de publication:
20 Nov 2023
Historique:
medline: 27 11 2023
pubmed: 25 10 2023
entrez: 24 10 2023
Statut: ppublish

Résumé

Methyleugenol (ME), found in numerous plants and spices, is a rodent carcinogen and is classified as "possibly carcinogenic to humans". The hypothesis of a carcinogenic risk for humans is supported by the observation of ME-derived DNA adducts in almost all human liver and lung samples examined. Therefore, a risk assessment of ME is needed. Unfortunately, biomarkers of exposure for epidemiological studies are not yet available. We hereby present the first detection of

Identifiants

pubmed: 37875262
doi: 10.1021/acs.chemrestox.3c00212
pmc: PMC10664145
doi:

Substances chimiques

Acetylcysteine WYQ7N0BPYC
Carcinogens 0
methyleugenol 29T9VA6R7M
DNA Adducts 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1753-1767

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Auteurs

Kai Nieschalke (K)

Department of Nutritional Toxicology, Institute of Nutritional Science, University of Potsdam, 14558 Nuthetal, Germany.
Department of Food Safety, German Federal Institute for Risk Assessment (BfR), 10589 Berlin, Germany.

Nick Bergau (N)

Department of Food Safety, German Federal Institute for Risk Assessment (BfR), 10589 Berlin, Germany.

Sönke Jessel (S)

Biochemical Institute for Environmental Carcinogens, Prof. Dr. Gernot Grimmer-Foundation, 22927 Grosshansdorf, Germany.

Albrecht Seidel (A)

Biochemical Institute for Environmental Carcinogens, Prof. Dr. Gernot Grimmer-Foundation, 22927 Grosshansdorf, Germany.

Susanne Baldermann (S)

Department Plant Quality and Food Security, Leibniz Institute of Vegetable and Ornamental Crops (IGZ), 14979 Grossbeeren, Germany.
Faculty of Life Sciences: Food, Nutrition & Health, University of Bayreuth, 95326 Kulmbach, Germany.

Monika Schreiner (M)

Department Plant Quality and Food Security, Leibniz Institute of Vegetable and Ornamental Crops (IGZ), 14979 Grossbeeren, Germany.

Klaus Abraham (K)

Department of Food Safety, German Federal Institute for Risk Assessment (BfR), 10589 Berlin, Germany.

Alfonso Lampen (A)

Department of Food Safety, German Federal Institute for Risk Assessment (BfR), 10589 Berlin, Germany.

Bernhard H Monien (BH)

Department of Food Safety, German Federal Institute for Risk Assessment (BfR), 10589 Berlin, Germany.

Burkhard Kleuser (B)

Department of Nutritional Toxicology, Institute of Nutritional Science, University of Potsdam, 14558 Nuthetal, Germany.
Department of Pharmacology and Toxicology, Institute of Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany.

Hansruedi Glatt (H)

Department of Food Safety, German Federal Institute for Risk Assessment (BfR), 10589 Berlin, Germany.

Fabian Schumacher (F)

Department of Nutritional Toxicology, Institute of Nutritional Science, University of Potsdam, 14558 Nuthetal, Germany.
Department of Pharmacology and Toxicology, Institute of Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany.

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Classifications MeSH