A Mediterranean Diet-Based Metabolomic Score and Cognitive Decline in Older Adults: A Case-Control Analysis Nested within the Three-City Cohort Study.

Alzheimer's disease aging cognitive dysfunction cognitive impairment metabolite

Journal

Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818

Informations de publication

Date de publication:
24 Oct 2023
Historique:
revised: 04 08 2023
received: 29 04 2023
medline: 25 10 2023
pubmed: 25 10 2023
entrez: 25 10 2023
Statut: aheadofprint

Résumé

Evidence on the Mediterranean diet (MD) and age-related cognitive decline (CD) is still inconclusive partly due to self-reported dietary assessment. The aim of the current study is to develop an MD- metabolomic score (MDMS) and investigate its association with CD in community-dwelling older adults. This study includes participants from the Three-City Study from the Bordeaux (n = 418) and Dijon (n = 422) cohorts who are free of dementia at baseline. Repeated measures of cognition over 12 years are collected. An MDMS is designed based on serum biomarkers related to MD key food groups and using a targeted metabolomics platform. Associations with CD are investigated through conditional logistic regression (matched on age, sex, and education level) in both sample sets. The MDMS is found to be inversely associated with CD (odds ratio [OR] [95% confidence interval (CI)] = 0.90 [0.80-1.00]; p = 0.048) in the Bordeaux (discovery) cohort. Results are comparable in the Dijon (validation) cohort, with a trend toward significance (OR [95% CI] = 0.91 [0.83-1.01]; p = 0.084). A greater adherence to the MD, here assessed by a serum MDMS, is associated with lower odds of CD in older adults.

Identifiants

pubmed: 37876144
doi: 10.1002/mnfr.202300271
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2300271

Subventions

Organisme : Medical Research Council
ID : MR/N030087/1
Pays : United Kingdom

Informations de copyright

© 2023 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.

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Auteurs

Alba Tor-Roca (A)

Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, Food Science and Nutrition Torribera Campus, University of Barcelona, Santa Coloma de Gramenet, 08921, Spain.
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, 28029, Spain.

Alex Sánchez-Pla (A)

Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, 28029, Spain.
Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, 08028, Spain.

Aniko Korosi (A)

Brain Plasticity Group, Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, 1098 XH, The Netherlands.

Mercè Pallàs (M)

Pharmacology Section, Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences and Institut of Neurosciences, University of Barcelona, Barcelona, 08028, Spain.
Centro de Investigación Biomédica en Red en Neurodegeneracion, Instituto de Salud Carlos III, Madrid, 28029, Spain.

Paul J Lucassen (PJ)

Brain Plasticity Group, Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, 1098 XH, The Netherlands.

Pol Castellano-Escuder (P)

Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, Food Science and Nutrition Torribera Campus, University of Barcelona, Santa Coloma de Gramenet, 08921, Spain.
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, 28029, Spain.
Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, 08028, Spain.

Ludwig Aigner (L)

Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, 5020, Austria.

Raúl González-Domínguez (R)

Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, Food Science and Nutrition Torribera Campus, University of Barcelona, Santa Coloma de Gramenet, 08921, Spain.
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, 28029, Spain.

Claudine Manach (C)

Université Clermont Auvergne, INRAE, UNH, Clermont-Ferrand, F-63000, France.

Francisco Carmona (F)

Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, 28029, Spain.
Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, 08028, Spain.

Esteban Vegas (E)

Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, 28029, Spain.
Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, 08028, Spain.

Catherine Helmer (C)

University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, F-33000, France.

Catherine Feart (C)

University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, F-33000, France.

Sophie Lefèvre-Arbogast (S)

University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, F-33000, France.

Jeanne Neuffer (J)

University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, F-33000, France.

Hyunah Lee (H)

Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK.

Sandrine Thuret (S)

Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK.

Cristina Andres-Lacueva (C)

Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, Food Science and Nutrition Torribera Campus, University of Barcelona, Santa Coloma de Gramenet, 08921, Spain.
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, 28029, Spain.

Cécilia Samieri (C)

University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, F-33000, France.

Mireia Urpi-Sarda (M)

Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, Food Science and Nutrition Torribera Campus, University of Barcelona, Santa Coloma de Gramenet, 08921, Spain.
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, 28029, Spain.

Classifications MeSH