Inflammatory arthritis and eye diseases: a Mendelian randomization study.
Mendelian randomization
ankylosing spondylitis
eye diseases
inflammatory arthritis
psoriatic arthritis
rheumatoid arthritis
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
01
07
2023
accepted:
21
09
2023
medline:
26
10
2023
pubmed:
25
10
2023
entrez:
25
10
2023
Statut:
epublish
Résumé
The aim of this study was to determine causal associations between inflammatory arthritis and eye diseases (disorders of sclera, cornea, iris, and ciliary body [DSCIC] and disorders of choroid and retina [DCR]). Genome-wide association studies' summary data of rheumatoid arthritis (RA) from a large-scale meta-analysis were used to identify genetically predicted RA. UK Biobank source data predicted ankylosing spondylitis (AS), psoriatic arthritis (PsA), and juvenile idiopathic arthritis (JIA). Furthermore, data from the FinnGen Biobank were used to identify genetically predicted eye diseases. Two-sample Mendelian randomization analysis was used to assess the causal relationship between inflammatory arthritis and eye diseases in the European population. Inverse-variance weighting (IVW) was used as the primary method, while MR-Egger, weighted median, and MR-PRESSO outlier test were used to detect heterogeneity and pleiotropy. Genetically determined RA was indeed observed to have a causal effect on DSCIC (odds ratio [OR] = 1.084, Our study provided genetic evidence for the causal associations of RA, AS, and PsA with an increased risk of DSCIC, and a causal association between RA and DCR was also identified. In addition, DSCIC greatly increased the risk of JIA.
Identifiants
pubmed: 37876547
doi: 10.3389/fendo.2023.1251167
pmc: PMC10591326
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1251167Informations de copyright
Copyright © 2023 Nie, Liu, Xie and Sun.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):3520-3526
pubmed: 31412111
Int J Epidemiol. 2003 Feb;32(1):1-22
pubmed: 12689998
Cochrane Database Syst Rev. 2012 Jan 18;1:CD008951
pubmed: 22258995
Int J Rheum Dis. 2011 Oct;14(4):320-4
pubmed: 22004227
Best Pract Res Clin Rheumatol. 2006 Jun;20(3):487-505
pubmed: 16777578
Lancet. 1973 Apr 28;1(7809):904-7
pubmed: 4123836
Am J Ophthalmol. 2005 Nov;140(5):808-13
pubmed: 16289424
Autoimmun Rev. 2021 Feb;20(2):102735
pubmed: 33346115
Ann Rheum Dis. 1995 Apr;54(4):321-4
pubmed: 7763114
BMJ. 1997 Dec 6;315(7121):1533-7
pubmed: 9432252
Ophthalmology. 1994 Jul;101(7):1281-6; discussion 1287-8
pubmed: 8035992
Invest Ophthalmol Vis Sci. 2008 Feb;49(2):560-4
pubmed: 18234999
Rheumatology (Oxford). 2016 Feb;55(2):246-51
pubmed: 26338663
Eur J Epidemiol. 2017 May;32(5):377-389
pubmed: 28527048
Ann Rheum Dis. 1996 Mar;55(3):187-9
pubmed: 8712882
Rheumatology (Oxford). 2001 Aug;40(8):928-32
pubmed: 11511763
J Korean Med Sci. 2011 Jul;26(7):938-44
pubmed: 21738349
Ophthalmology. 2001 Nov;108(11):2071-5
pubmed: 11713082
Elife. 2018 May 30;7:
pubmed: 29846171
Nat Genet. 2012 Mar 18;44(4):369-75, S1-3
pubmed: 22426310
N Engl J Med. 2017 Apr 27;376(17):1637-1646
pubmed: 28445659
Ophthalmology. 2004 Mar;111(3):501-6
pubmed: 15019326
Neurobiol Aging. 2021 Mar;99:101.e11-101.e13
pubmed: 33139072
Nat Genet. 2018 May;50(5):693-698
pubmed: 29686387
Surv Ophthalmol. 2022 Mar-Apr;67(2):510-529
pubmed: 34181974
Korean J Ophthalmol. 2011 Apr;25(2):73-6
pubmed: 21461217
Clin Exp Rheumatol. 1996 Jul-Aug;14(4):441-4
pubmed: 8871846
Lancet. 1973 Nov 3;302(7836):994-6
pubmed: 4127279
Nat Genet. 2021 Oct;53(10):1415-1424
pubmed: 34594039
Nature. 2023 Jan;613(7944):508-518
pubmed: 36653562
Nat Genet. 2013 Jun;45(6):664-9
pubmed: 23603761
Stat Med. 2008 Apr 15;27(8):1133-63
pubmed: 17886233
Rheumatology (Oxford). 2021 Jun 18;60(6):2725-2734
pubmed: 33216939
Nat Rev Rheumatol. 2020 Apr;16(4):193-207
pubmed: 32080619
Innate Immun. 2013;19(4):348-54
pubmed: 23204037
PLoS One. 2013 Dec 12;8(12):e83555
pubmed: 24349530
Ann Rheum Dis. 2018 Feb;77(2):277-280
pubmed: 29092855
Arthritis Rheum. 1995 Apr;38(4):547-50
pubmed: 7718009
Int J Epidemiol. 2011 Jun;40(3):740-52
pubmed: 20813862
Pediatr Rheumatol Online J. 2023 Jun 15;21(1):56
pubmed: 37322490
Autoimmun Rev. 2021 May;20(5):102796
pubmed: 33722750
Ann Rheum Dis. 2008 Jul;67(7):955-9
pubmed: 17962239
Br J Ophthalmol. 2021 Oct;105(10):1395-1398
pubmed: 32863277
Wellcome Open Res. 2019 Nov 26;4:186
pubmed: 32760811
Nat Med. 2015 Aug;21(8):895-905
pubmed: 26214836
Exp Eye Res. 2010 May;90(5):583-90
pubmed: 20153319
Cornea. 2012 Dec;31(12):1493-6
pubmed: 23023405
Ann Rheum Dis. 2021 May;80(5):558-565
pubmed: 33310728
Pediatr Rheumatol Online J. 2023 Jun 20;21(1):59
pubmed: 37340311
Acta Ophthalmol Scand. 2000 Feb;78(1):84-8
pubmed: 10726797
Clin Nutr. 2021 Jun;40(6):4120-4131
pubmed: 33610420
Ophthalmology. 2003 Jul;110(7):1321-6
pubmed: 12867385
Acta Ophthalmol. 2021 Mar;99(2):e160-e163
pubmed: 32588987
Innate Immun. 2013;19(4):420-7
pubmed: 23339928
Rheumatology (Oxford). 2022 Nov 28;61(12):4656-4666
pubmed: 35377442
Arthritis Rheumatol. 2015 Jan;67(1):128-39
pubmed: 25319745
Nat Genet. 2021 Nov;53(11):1616-1621
pubmed: 34737426
Ophthalmology. 1987 Oct;94(10):1242-8
pubmed: 3684202