Effect of
IL-6
TNF-α
ethanol extract of Phaleria Macrocarpa leaf
serum
Journal
Medical archives (Sarajevo, Bosnia and Herzegovina)
ISSN: 1986-5961
Titre abrégé: Med Arch
Pays: Bosnia and Herzegovina
ID NLM: 101635337
Informations de publication
Date de publication:
2023
2023
Historique:
received:
26
05
2023
accepted:
24
07
2023
medline:
26
10
2023
pubmed:
25
10
2023
entrez:
25
10
2023
Statut:
ppublish
Résumé
Hyperglycemia conditions in diabetes mellitus (DM) can turn on pro-inflammatory cytokines like IL-6 and TNF-α. These cytokines play a role in insulin resistance and the development of DM complications. People in Indonesia have used This study aims to analyze the effect of ethanolic extract of This study was an experiment with a post-test-only control group design. Thirty 8-week-old male Wistar rats were used in the study. They were split into six groups: K1 was the normal control group; K2 was the DM control group; K3, K4, and K5 were given EEPML at doses of 125, 250, and 500 mg/KgBW; and K6 was given metformin 45 mg/KgBW orally once a day for 14 days. A high-fat diet and a 30 mg/KgBWi.p injection of streptozotocin were used to make the diabetic rat model. ELISA method for measuring serum IL-6 and TNF-α levels. The Kruskal-Wallis and the Mann-Whitney test were used to examine the differences between the groups. There were significant differences between treatment groups in the mean levels of serum IL-6 (p=0.017), but there were no significant differences in the mean levels of serum TNF-α (p>0.05). Administration of
Sections du résumé
Background
UNASSIGNED
Hyperglycemia conditions in diabetes mellitus (DM) can turn on pro-inflammatory cytokines like IL-6 and TNF-α. These cytokines play a role in insulin resistance and the development of DM complications. People in Indonesia have used
Objective
UNASSIGNED
This study aims to analyze the effect of ethanolic extract of
Methods
UNASSIGNED
This study was an experiment with a post-test-only control group design. Thirty 8-week-old male Wistar rats were used in the study. They were split into six groups: K1 was the normal control group; K2 was the DM control group; K3, K4, and K5 were given EEPML at doses of 125, 250, and 500 mg/KgBW; and K6 was given metformin 45 mg/KgBW orally once a day for 14 days. A high-fat diet and a 30 mg/KgBWi.p injection of streptozotocin were used to make the diabetic rat model. ELISA method for measuring serum IL-6 and TNF-α levels. The Kruskal-Wallis and the Mann-Whitney test were used to examine the differences between the groups.
Results
UNASSIGNED
There were significant differences between treatment groups in the mean levels of serum IL-6 (p=0.017), but there were no significant differences in the mean levels of serum TNF-α (p>0.05).
Conclusion
UNASSIGNED
Administration of
Identifiants
pubmed: 37876571
doi: 10.5455/medarh.2023.77.254-257
pmc: PMC10591243
doi:
Substances chimiques
Plant Extracts
0
Tumor Necrosis Factor-alpha
0
Interleukin-6
0
Ethanol
3K9958V90M
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
254-257Informations de copyright
© 2023 Ira Cinta Lestari, Dharma Lindarto, Syafruddin Ilyas, Tri Widyawati, Mustofa, Nelva Karmila Jusuf, Poppy Anjelisa Zaitun Hasibuan, Lambok Siahaan, Muhammad Rusda, Mustafa Mahmud Amin.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Crit Rev Eukaryot Gene Expr. 2017;27(3):229-236
pubmed: 29199608
Mediators Inflamm. 2006;2006(1):39062
pubmed: 16864902
J Inflamm (Lond). 2016 Nov 24;13:34
pubmed: 27904436
Vet World. 2021 Dec;14(12):3229-3234
pubmed: 35153417
BMC Complement Altern Med. 2013 Feb 20;13:39
pubmed: 23425283
Afr J Tradit Complement Altern Med. 2014 Apr 03;11(3):107-11
pubmed: 25371571
Ann Clin Lab Sci. 2006 Spring;36(2):174-8
pubmed: 16682514