The Global Burden of premature cardiovascular disease, 1990-2019.
Epidemiology
Global disease burden
Premature cardiovascular mortality
Journal
International journal of cardiology. Cardiovascular risk and prevention
ISSN: 2772-4875
Titre abrégé: Int J Cardiol Cardiovasc Risk Prev
Pays: Netherlands
ID NLM: 9918282077306676
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
02
06
2023
revised:
25
08
2023
accepted:
07
09
2023
medline:
25
10
2023
pubmed:
25
10
2023
entrez:
25
10
2023
Statut:
epublish
Résumé
Premature cardiovascular disease (pCVD) definition varies in literature, with age cut-offs ranging from 50-65 years. While there is some literature available on pCVD in North America, comprehensive data on its global burden is still lacking which hinders the development of efficient strategies for early detection and prevention. In this study we aimed to investigate the global trends in pCVD related morbidity and mortality from 1990 to 2019. The 1990-2019 Global Burden of Disease (GBD) database was utilized to examine global trends in cardiovascular disease-related total mortality, mortality rates, and Disability-Adjusted Life Years (DALYs) within individuals aged 15-49 years. The findings were further analyzed based on factors such as age, sex, and Socio-Demographic Index (SDI). From 1990 to 2019, the number of global annual pCVD deaths increased by 25%, from 992,067 (95% UI 1,042,261 - 946,383) to 1,241,484 (95% UI 1,339,193 -1,146,252). The rate of associated mortality decreased by 13%. Metabolic conditions were the most significant risk factors for pCVD mortality. Ischemic heart disease and stroke are the leading causes of death across all age groups. pCVD mortality presented progressive widening between high and low SDI regions. Additionally, sex-specific disparities in CVD mortality were significantly greater in the premature age group as compared to all-age groups. pCVD is an increasingly significant global cause of morbidity and mortality that disproportionately affects males and individuals living in less privileged regions. Furthermore, ischemic heart disease and stroke were identified as the main drivers of pCVD global burden.
Identifiants
pubmed: 37876911
doi: 10.1016/j.ijcrp.2023.200212
pii: S2772-4875(23)00045-4
pmc: PMC10590819
doi:
Types de publication
Journal Article
Langues
eng
Pagination
200212Informations de copyright
© 2023 Published by Elsevier B.V.
Déclaration de conflit d'intérêts
None.
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