A Rare Case of Refractory Catastrophic Antiphospholipid Syndrome Successfully Treated With Rituximab and Plasma Exchange.
Journal
Journal of community hospital internal medicine perspectives
ISSN: 2000-9666
Titre abrégé: J Community Hosp Intern Med Perspect
Pays: United States
ID NLM: 101601396
Informations de publication
Date de publication:
2023
2023
Historique:
received:
25
11
2022
revised:
01
02
2023
accepted:
15
02
2023
medline:
25
10
2023
pubmed:
25
10
2023
entrez:
25
10
2023
Statut:
epublish
Résumé
A small subset of patients with antiphospholipid syndrome (APS) may develop widespread thrombotic disease with organ damage, referred to as catastrophic APS (CAPS) that is associated with a high mortality. Medical therapy typically involves a combination of anticoagulation, systemic glucocorticoids, plasmapheresis, and intravenous immune globulin (IVIG). There is currently no consensus for the management of refractory cases of CAPS. However, monoclonal antibodies such as rituximab and eculizumab have shown some benefits. Herein, we present a 29-year-old female with previous pulmonary embolism who presented with necrotic left toes and was eventually diagnosed with refractory CAPS, successfully treated with Plasmapheresis and Rituximab. With this case report, we hope to encourage the usage of Rituximab in the management of CAPS.
Identifiants
pubmed: 37877050
doi: 10.55729/2000-9666.1175
pii: jchim-13-03-079
pmc: PMC10593160
doi:
Types de publication
Case Reports
Langues
eng
Pagination
79-82Informations de copyright
© 2023 Greater Baltimore Medical Center.
Déclaration de conflit d'intérêts
Conflict of interest Not applicable.
Références
Arthritis Rheum. 2002 Apr;46(4):1019-27
pubmed: 11953980
Medicine (Baltimore). 2003 Mar;82(2):106-18
pubmed: 12640187
Curr Opin Rheumatol. 2016 May;28(3):218-27
pubmed: 26927441
J Rheumatol. 2006 Feb;33(2):355-7
pubmed: 16465669
Arthritis Rheum. 2003 Dec;48(12):3320-7
pubmed: 14673983
Semin Thromb Hemost. 2008 Apr;34(3):290-4
pubmed: 18720310
J Thromb Haemost. 2018 Aug;16(8):1656-1664
pubmed: 29978552