Myotube growth is associated with cancer-like metabolic reprogramming and is limited by phosphoglycerate dehydrogenase.
Glycolysis
Hypertrophy
Insulin-like growth factor I
Metabolism
Skeletal muscle
Warburg effect
Journal
Experimental cell research
ISSN: 1090-2422
Titre abrégé: Exp Cell Res
Pays: United States
ID NLM: 0373226
Informations de publication
Date de publication:
15 Dec 2023
15 Dec 2023
Historique:
received:
30
06
2022
revised:
10
10
2023
accepted:
14
10
2023
pubmed:
26
10
2023
medline:
26
10
2023
entrez:
25
10
2023
Statut:
ppublish
Résumé
The Warburg effect links growth and glycolysis in cancer. A key purpose of the Warburg effect is to generate glycolytic intermediates for anabolic reactions, such as nucleotides → RNA/DNA and amino acids → protein synthesis. The aim of this study was to investigate whether a similar 'glycolysis-for-anabolism' metabolic reprogramming also occurs in hypertrophying skeletal muscle. To interrogate this, we first induced C2C12 myotube hypertrophy with IGF-1. We then added
Identifiants
pubmed: 37879549
pii: S0014-4827(23)00371-3
doi: 10.1016/j.yexcr.2023.113820
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113820Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.