Usefulness of FAPα assessment in bronchoalveolar lavage as a marker of fibrogenesis: results of a preclinical study and first report in patients with idiopathic pulmonary fibrosis.
Biomarker
Bronchoalveolar lavage
FAPI
Fibroblast activation protein
Idiopathic pulmonary fibrosis
PET scan
Journal
Respiratory research
ISSN: 1465-993X
Titre abrégé: Respir Res
Pays: England
ID NLM: 101090633
Informations de publication
Date de publication:
25 Oct 2023
25 Oct 2023
Historique:
received:
20
07
2023
accepted:
05
10
2023
medline:
27
10
2023
pubmed:
26
10
2023
entrez:
25
10
2023
Statut:
epublish
Résumé
Fibroblast activation protein-α (FAPα) is a marker of activated fibroblasts that can be selectively targeted by an inhibitor (FAPI) and visualised by PET/CT imaging. We evaluated whether the measurement of FAPα in bronchoalveolar lavage fluids (BALF) and the uptake of FAPI by PET/CT could be used as biomarkers of fibrogenesis. The dynamics of lung uptake of Bleomycin-treated mice presented a significantly higher uptake of [ Our preclinical data highlight a specific increase of [
Sections du résumé
BACKGROUND
BACKGROUND
Fibroblast activation protein-α (FAPα) is a marker of activated fibroblasts that can be selectively targeted by an inhibitor (FAPI) and visualised by PET/CT imaging. We evaluated whether the measurement of FAPα in bronchoalveolar lavage fluids (BALF) and the uptake of FAPI by PET/CT could be used as biomarkers of fibrogenesis.
METHODS
METHODS
The dynamics of lung uptake of
RESULTS
RESULTS
Bleomycin-treated mice presented a significantly higher uptake of [
CONCLUSIONS
CONCLUSIONS
Our preclinical data highlight a specific increase of [
Identifiants
pubmed: 37880678
doi: 10.1186/s12931-023-02556-6
pii: 10.1186/s12931-023-02556-6
pmc: PMC10601150
doi:
Substances chimiques
fibroblast activation protein alpha
EC 3.4.21.-
Bleomycin
11056-06-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
254Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
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