Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy.
CAR-T
Differentiation
Exhaustion
Memory
T cell
Journal
Journal of hematology & oncology
ISSN: 1756-8722
Titre abrégé: J Hematol Oncol
Pays: England
ID NLM: 101468937
Informations de publication
Date de publication:
25 10 2023
25 10 2023
Historique:
received:
24
08
2023
accepted:
12
10
2023
medline:
27
10
2023
pubmed:
26
10
2023
entrez:
26
10
2023
Statut:
epublish
Résumé
T cell differentiation is a highly regulated, multi-step process necessary for the progressive establishment of effector functions, immunological memory, and long-term control of pathogens. In response to strong stimulation, as seen in severe or chronic infections or cancer, T cells acquire a state of hypo-responsiveness known as exhaustion, limiting their effector function. Recent advances in autologous chimeric antigen receptor (CAR)-T cell therapies have revolutionized the treatment of hematologic malignancies by taking advantage of the basic principles of T cell biology to engineer products that promote long-lasting T cell response. However, many patients' malignancies remain unresponsive to treatment or are prone to recur. Discoveries in T cell biology, including the identification of key regulators of differentiation and exhaustion, offer novel opportunities to have a durable impact on the fate of CAR-T cells after infusion. Such next-generation CAR-T cell therapies and their clinical implementation may result in the next leap forward in cancer treatment for selected patients. In this context, this review summarizes the foundational principles of T cell differentiation and exhaustion and describes how they can be utilized and targeted to further improve the design and efficacy of CAR-T cell therapies.
Identifiants
pubmed: 37880715
doi: 10.1186/s13045-023-01504-7
pii: 10.1186/s13045-023-01504-7
pmc: PMC10601191
doi:
Substances chimiques
Receptors, Chimeric Antigen
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
Références
Clin Cancer Res. 2021 Nov 1;27(21):6054-6064
pubmed: 34376537
Immunity. 2018 May 15;48(5):1029-1045.e5
pubmed: 29768164
J Exp Med. 2018 Oct 1;215(10):2520-2535
pubmed: 30154266
N Engl J Med. 2018 Feb 1;378(5):439-448
pubmed: 29385370
Nat Med. 2020 Dec;26(12):1878-1887
pubmed: 33020644
J Transl Med. 2021 Dec 7;19(1):499
pubmed: 34876185
Nature. 2019 Jul;571(7764):270-274
pubmed: 31207604
Nature. 2019 Mar;567(7749):530-534
pubmed: 30814732
Front Immunol. 2019 Mar 07;10:400
pubmed: 30899267
Immunity. 2013 Aug 22;39(2):286-97
pubmed: 23932570
Immunity. 2009 Aug 21;31(2):309-20
pubmed: 19664943
Nat Rev Immunol. 2020 Feb;20(2):128-136
pubmed: 31591533
Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12410-12415
pubmed: 31152140
Clin Cancer Res. 2018 Mar 15;24(6):1277-1286
pubmed: 29138340
Nature. 2023 Sep;621(7980):849-856
pubmed: 37730993
Curr Opin Hematol. 2015 Nov;22(6):509-515
pubmed: 26390167
Cell. 2017 Jun 29;170(1):142-157.e19
pubmed: 28648661
Nat Commun. 2021 May 13;12(1):2782
pubmed: 33986293
Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2776-E2785
pubmed: 28283662
Cell. 2018 Nov 1;175(4):998-1013.e20
pubmed: 30388456
Sci Adv. 2022 Jun 10;8(23):eabj2820
pubmed: 35675405
Front Immunol. 2018 Dec 18;9:2981
pubmed: 30619337
Blood Adv. 2019 Jul 9;3(13):2022-2034
pubmed: 31289029
Nat Immunol. 2019 Mar;20(3):326-336
pubmed: 30778252
Trends Immunol. 2018 Oct;39(10):830-847
pubmed: 30213499
Nat Med. 2022 Sep;28(9):1848-1859
pubmed: 36097221
Immunity. 2010 Aug 27;33(2):229-40
pubmed: 20727791
Cancer Immunol Res. 2023 Feb 3;11(2):144
pubmed: 36630221
Immunity. 2022 Mar 8;55(3):475-493.e5
pubmed: 35216666
Leukemia. 2016 Feb;30(2):492-500
pubmed: 26369987
Nat Rev Immunol. 2013 Feb;13(2):101-17
pubmed: 23334244
J Immunother Cancer. 2021 May;9(5):
pubmed: 34006631
Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19454-9
pubmed: 17159138
Proc Natl Acad Sci U S A. 2010 May 25;107(21):9777-82
pubmed: 20457902
J Clin Invest. 2016 Feb;126(2):599-604
pubmed: 26731475
Cancer Cell. 2022 Nov 14;40(11):1407-1422.e7
pubmed: 36240777
Nat Rev Immunol. 2012 Mar 22;12(4):269-81
pubmed: 22437939
Nat Immunol. 2016 Apr;17(4):422-32
pubmed: 26950239
J Exp Med. 2018 Feb 5;215(2):575-594
pubmed: 29282254
Nature. 2019 Jul;571(7764):265-269
pubmed: 31207605
J Exp Med. 2015 Jun 29;212(7):1125-37
pubmed: 26034050
Trends Immunol. 2021 Apr;42(4):336-349
pubmed: 33663954
Blood. 2018 Aug 23;132(8):804-814
pubmed: 29895668
JCI Insight. 2018 May 17;3(10):
pubmed: 29769444
Nat Med. 2017 Jan 6;23(1):18-27
pubmed: 28060797
Immunity. 2007 Aug;27(2):281-95
pubmed: 17723218
Front Immunol. 2021 Jul 20;12:715234
pubmed: 34354714
Cell Mol Immunol. 2021 May;18(5):1262-1277
pubmed: 32341523
J Exp Med. 2013 Jun 3;210(6):1189-200
pubmed: 23712431
Nat Immunol. 2005 Dec;6(12):1236-44
pubmed: 16273099
Blood. 2014 Oct 30;124(18):2824-33
pubmed: 25049283
Immunity. 2019 Jan 15;50(1):195-211.e10
pubmed: 30635237
J Hematol Oncol. 2021 Jun 30;14(1):102
pubmed: 34193217
Immunity. 2018 Apr 17;48(4):659-674.e6
pubmed: 29669249
Immunity. 2013 Aug 22;39(2):347-56
pubmed: 23932571
Sci Immunol. 2022 Aug 12;7(74):eabn6563
pubmed: 35984893
Cancer Discov. 2018 Aug;8(8):944-957
pubmed: 29891538
Nat Immunol. 2014 Apr;15(4):373-83
pubmed: 24584090
Nat Immunol. 2006 May;7(5):466-74
pubmed: 16565720
Cancer Discov. 2021 Sep;11(9):2186-2199
pubmed: 33820778
J Exp Med. 2016 Aug 22;213(9):1819-34
pubmed: 27455951
Sci Transl Med. 2022 Nov 9;14(670):eabn7336
pubmed: 36350986
Nat Biotechnol. 2023 Nov;41(11):1606-1617
pubmed: 36849828
Sci Transl Med. 2021 Oct 13;13(615):eaba6006
pubmed: 34644150
Immunity. 2016 Feb 16;44(2):380-90
pubmed: 26885860
J Immunol. 2010 Nov 1;185(9):4988-92
pubmed: 20935204
Immunity. 2015 Feb 17;42(2):265-278
pubmed: 25680272
Cell Rep. 2021 Sep 7;36(10):109672
pubmed: 34496259
Immunity. 2019 Jan 15;50(1):181-194.e6
pubmed: 30635236
Nat Med. 2010 Oct;16(10):1147-51
pubmed: 20890291
Nat Immunol. 2020 Dec;21(12):1552-1562
pubmed: 33046887
Sci Adv. 2021 Feb 26;7(9):
pubmed: 33637530
Mol Ther. 2019 Jun 5;27(6):1126-1138
pubmed: 31005597
Science. 2020 Dec 11;370(6522):1328-1334
pubmed: 33303615
Sci Transl Med. 2021 Nov 17;13(620):eabh0272
pubmed: 34788079
Nat Immunol. 2016 Jun;17(6):695-703
pubmed: 27111144
Immunity. 2012 Mar 23;36(3):374-87
pubmed: 22425248
Cancer Immunol Res. 2023 Feb 3;11(2):171-183
pubmed: 36484736
Science. 2018 Mar 23;359(6382):1361-1365
pubmed: 29567707
Immunity. 2016 Aug 16;45(2):415-27
pubmed: 27533016
Immunity. 2017 Dec 19;47(6):1129-1141.e5
pubmed: 29246443
Nature. 2018 Feb 15;554(7692):392
pubmed: 29320476
Blood Adv. 2020 Oct 13;4(19):4898-4911
pubmed: 33035333
Cell Rep. 2021 Jan 26;34(4):108674
pubmed: 33503413
Cell Stem Cell. 2019 Oct 3;25(4):542-557.e9
pubmed: 31495780
Front Immunol. 2023 Jun 20;14:1117092
pubmed: 37409128
Cancer Cell. 2023 Jul 10;41(7):1276-1293.e11
pubmed: 37244259
Cancer Cell. 2022 Jul 11;40(7):768-786.e7
pubmed: 35750052
Nat Med. 2023 Jun;29(6):1379-1388
pubmed: 37188782
J Clin Invest. 2016 Aug 1;126(8):3130-44
pubmed: 27454297
Front Endocrinol (Lausanne). 2021 Feb 01;11:624122
pubmed: 33597928
Nat Commun. 2020 Jan 10;11(1):219
pubmed: 31924795
Nat Immunol. 2021 Aug;22(8):983-995
pubmed: 34282330
J Immunother Cancer. 2021 May;9(5):
pubmed: 33963013
Nature. 2017 May 25;545(7655):452-456
pubmed: 28514453
Clin Transl Immunology. 2022 Feb 02;11(2):e1373
pubmed: 35136603
J Exp Med. 2003 Nov 3;198(9):1369-80
pubmed: 14581610
Front Immunol. 2022 Apr 28;13:878209
pubmed: 35572525
Semin Cancer Biol. 2020 Dec;67(Pt 1):57-64
pubmed: 31445218
Immunity. 2016 Aug 16;45(2):389-401
pubmed: 27521269
Immunity. 2013 Oct 17;39(4):661-75
pubmed: 24120360
Immunity. 2009 Aug 21;31(2):296-308
pubmed: 19664941
Nat Immunol. 2013 Jun;14(6):603-10
pubmed: 23644506
Nat Immunol. 2021 Mar;22(3):370-380
pubmed: 33574619
Nature. 2019 Mar;567(7749):525-529
pubmed: 30814730
Cancers (Basel). 2019 Jul 23;11(7):
pubmed: 31340499
Cancer Cell. 2020 Oct 12;38(4):551-566.e11
pubmed: 32860752
Nat Commun. 2013;4:2830
pubmed: 24335726
Front Immunol. 2021 Aug 26;12:725618
pubmed: 34512656
Nat Med. 2018 May;24(5):563-571
pubmed: 29713085
Int Immunol. 2005 Jun;17(6):713-9
pubmed: 15837711
Nat Med. 2018 Jul;24(7):994-1004
pubmed: 29892065
Cell Rep. 2018 Mar 27;22(13):3454-3467
pubmed: 29590615
Cell Rep Med. 2021 Nov 16;2(11):100449
pubmed: 34841295
Trends Immunol. 2014 Feb;35(2):51-60
pubmed: 24210163
Nat Immunol. 2021 Aug;22(8):996-1007
pubmed: 34282329
Nat Rev Immunol. 2015 Aug;15(8):486-99
pubmed: 26205583
Nat Rev Cancer. 2020 Apr;20(4):218-232
pubmed: 32024970
Sci Rep. 2017 Apr 7;7(1):737
pubmed: 28389661
Nature. 2019 Jul;571(7764):211-218
pubmed: 31207603
Nature. 2019 Dec;576(7786):293-300
pubmed: 31802004
Sci Transl Med. 2015 Sep 2;7(303):303ra139
pubmed: 26333935
Front Immunol. 2018 Jul 30;9:1770
pubmed: 30131803
Nat Immunol. 2022 Nov;23(11):1600-1613
pubmed: 36271148
Immunity. 2020 May 19;52(5):825-841.e8
pubmed: 32396847
Nature. 2017 Dec 14;552(7684):253-257
pubmed: 29211713
Science. 2018 Jan 12;359(6372):177-186
pubmed: 29326266
Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14885-9
pubmed: 21873234
N Engl J Med. 2019 May 2;380(18):1726-1737
pubmed: 31042825
Nature. 2016 Sep 15;537(7620):417-421
pubmed: 27501248
Cancer Discov. 2023 Sep 6;13(9):1982-1997
pubmed: 37249512
Annu Rev Immunol. 2007;25:171-92
pubmed: 17129182
Cell. 2021 Dec 9;184(25):6101-6118.e13
pubmed: 34852236
J Immunol. 2013 Apr 1;190(7):3207-15
pubmed: 23455505
Nat Rev Immunol. 2019 Nov;19(11):665-674
pubmed: 31570879
Cancer Cell. 2022 Dec 12;40(12):1470-1487.e7
pubmed: 36513049
Nat Immunol. 2016 Jul;17(7):851-860
pubmed: 27158840
Biochim Biophys Acta. 2016 Jan;1865(1):90-100
pubmed: 26748354
Science. 2012 Nov 30;338(6111):1220-5
pubmed: 23197535
J Immunol. 2011 May 1;186(9):5068-77
pubmed: 21430221
Cell Rep. 2018 Feb 20;22(8):2107-2117
pubmed: 29466737
Science. 2016 Dec 2;354(6316):1165-1169
pubmed: 27789799
Nat Commun. 2020 Nov 19;11(1):5902
pubmed: 33214555
Nat Immunol. 2017 Apr;18(4):422-432
pubmed: 28218746
Cancer Cell. 2022 Jan 10;40(1):53-69.e9
pubmed: 34971569
Cell. 2020 Jun 25;181(7):1612-1625.e13
pubmed: 32497499
Nat Rev Clin Oncol. 2020 Mar;17(3):147-167
pubmed: 31848460
Immunity. 2014 Nov 20;41(5):802-14
pubmed: 25464856
Nat Immunol. 2011 May 29;12(7):663-71
pubmed: 21623380
N Engl J Med. 2017 Dec 28;377(26):2531-2544
pubmed: 29226797
Immunity. 2016 Dec 20;45(6):1327-1340
pubmed: 27939672
Science. 2016 Dec 2;354(6316):1160-1165
pubmed: 27789795
Cancer Immunol Res. 2019 Oct;7(10):1564-1569
pubmed: 31575551
Nat Immunol. 2014 Apr;15(4):365-372
pubmed: 24584088
Nat Immunol. 2014 Dec;15(12):1143-51
pubmed: 25344724
Nature. 2022 Jul;607(7917):135-141
pubmed: 35732731
Elife. 2022 Dec 02;11:
pubmed: 36458691
Sci Immunol. 2016 Dec 23;1(6):
pubmed: 28018990
Cell Rep. 2015 Nov 10;13(6):1118-1124
pubmed: 26527008
Nature. 2023 Feb;614(7949):635-648
pubmed: 36813894
Nat Immunol. 2002 Jun;3(6):558-63
pubmed: 12021781
Curr Oncol Rep. 2023 May;25(5):479-489
pubmed: 36853475
Sci Immunol. 2020 Jul 3;5(49):
pubmed: 32620560