Sorafenib tosylate-loaded nanosuspension: preparation, optimization, and
Central composite design
HepG2 cells
hepatocellular cancer
nanoprecipitation
nanosuspension
quadratic model
sorafenib tosylate
Journal
Journal of chemotherapy (Florence, Italy)
ISSN: 1973-9478
Titre abrégé: J Chemother
Pays: England
ID NLM: 8907348
Informations de publication
Date de publication:
25 Oct 2023
25 Oct 2023
Historique:
medline:
26
10
2023
pubmed:
26
10
2023
entrez:
26
10
2023
Statut:
aheadofprint
Résumé
This study aimed to optimize nanosuspension of sorafenib tosylate (an anticancer hydrophobic drug molecule) using a central composite design. Nanosuspension was prepared using a nanoprecipitation-ultrasonication approach. FTIR and DSC analyses demonstrated that the drug and excipients were physicochemically compatible. X-ray powder diffraction analysis confirmed amorphous form of the payload in the formulation. The optimized formulation (batch NSS
Identifiants
pubmed: 37881008
doi: 10.1080/1120009X.2023.2273095
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM