Evaluation of clinical parameters and biomarkers in older, untreated mantle cell lymphoma patients receiving bendamustine-rituximab.
MCL35
MIPI
mantle cell lymphoma
prognosis
proliferation
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
25 Oct 2023
25 Oct 2023
Historique:
revised:
26
09
2023
received:
20
07
2023
accepted:
29
09
2023
pubmed:
26
10
2023
medline:
26
10
2023
entrez:
26
10
2023
Statut:
aheadofprint
Résumé
Mantle cell lymphoma (MCL) is clinically and biologically heterogeneous. While various prognostic features have been proposed, none currently impact therapy selection, particularly in older patients, for whom treatment is primarily dictated by age and comorbidities. Herein, we undertook a comprehensive comparison of clinicopathological features in a cohort of patients 60 years and older, uniformly treated with bendamustine and rituximab, with a median survival of >8 years. The strongest prognostic indicators in this cohort were a high-risk call by a simplified MCL international prognostic index (s-MIPI) (HR: 3.32, 95% CI: 1.65-6.68 compared to low risk), a high-risk call by MCL35 (HR: 10.34, 95% CI: 2.37-45.20 compared to low risk) and blastoid cytology (HR: 4.21, 95% CR: 1.92-9.22 compared to classic). Patients called high risk by both the s-MIPI and MCL35 had the most dismal prognosis (HR: 11.58, 95% CI: 4.10-32.72), while those with high risk by either had a moderate but clinically relevant prognosis (HR: 2.95, 95% CI: 1.49-5.82). A robust assay to assess proliferation, such as MCL35, along with stringent guidelines for cytological evaluation of MCL, in combination with MIPI, may be a strong path to risk-stratify older MCL patients in future clinical trials.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : UH2 CA217847
Pays : United States
Organisme : NCI NIH HHS
ID : UH3 CA217847
Pays : United States
Organisme : NCI NIH HHS
ID : CA09274
Pays : United States
Organisme : NCI NIH HHS
ID : CA217847
Pays : United States
Organisme : NCI NIH HHS
ID : CA09274
Pays : United States
Organisme : NCI NIH HHS
ID : CA217847
Pays : United States
Informations de copyright
© 2023 British Society for Haematology and John Wiley & Sons Ltd.
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