"Input/output cytokines" in epidermal keratinocytes and the involvement in inflammatory skin diseases.
biologics
epidermal keratinocytes
inflammatory skin diseases
input cytokines
output cytokines
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
13
06
2023
accepted:
20
09
2023
medline:
27
10
2023
pubmed:
26
10
2023
entrez:
26
10
2023
Statut:
epublish
Résumé
Considering the role of epidermal keratinocytes, they occupy more than 90% of the epidermis, form a physical barrier, and also function as innate immune barrier. For example, epidermal keratinocytes are capable of recognizing various cytokines and pathogen-associated molecular pattern, and producing a wide variety of inflammatory cytokines, chemokines, and antimicrobial peptides. Previous basic studies have shown that the immune response of epidermal keratinocytes has a significant impact on inflammatory skin diseases. The purpose of this review is to provide foundation of knowledge on the cytokines which are recognized or produced by epidermal keratinocytes. Since a number of biologics for skin diseases have appeared, it is necessary to fully understand the relationship between epidermal keratinocytes and the cytokines. In this review, the cytokines recognized by epidermal keratinocytes are specifically introduced as "input cytokines", and the produced cytokines as "output cytokines". Furthermore, we also refer to the existence of biologics against those input and output cytokines, and the target skin diseases. These use results demonstrate how important targeted cytokines are in real skin diseases, and enhance our understanding of the cytokines.
Identifiants
pubmed: 37881433
doi: 10.3389/fimmu.2023.1239598
pmc: PMC10597658
doi:
Substances chimiques
Cytokines
0
Biological Products
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1239598Informations de copyright
Copyright © 2023 Morizane, Mukai, Sunagawa, Tachibana, Kawakami and Ouchida.
Déclaration de conflit d'intérêts
SM received research support from Sun Pharma Ltd., AbbVie GK, and Maruho Co., Ltd., and honoraria for lectures from Eli Lilly Japan K.K., AbbVie GK, Pfizer Japan Inc., Torii Pharmaceutical Co., Ltd, Sanofi K.K., and Maruho Co., Ltd. D. TM received scholarship donations from Eli Lilly Japan, Inc., LEO Pharma K.K., and AbbVie. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be constructed as a potential conflict of interest.
Références
Nat Med. 2015 Nov;21(11):1272-9
pubmed: 26479922
Eur J Immunol. 2009 Oct;39(10):2779-88
pubmed: 19731362
J Immunol. 2004 Feb 15;172(4):2006-10
pubmed: 14764663
Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21795-800
pubmed: 19996179
Front Immunol. 2021 Mar 16;12:652846
pubmed: 33796114
JCI Insight. 2018 Feb 22;3(4):
pubmed: 29467325
Science. 2010 Oct 29;330(6004):665-9
pubmed: 20929731
Nat Immunol. 2002 Jul;3(7):673-80
pubmed: 12055625
Nat Commun. 2019 Oct 16;10(1):4700
pubmed: 31619669
J Invest Dermatol. 2019 Apr;139(4):878-889
pubmed: 30423328
J Am Acad Dermatol. 2018 May;78(5):872-881.e6
pubmed: 29353025
J Allergy Clin Immunol. 2007 Jul;120(1):150-5
pubmed: 17512043
Int J Mol Sci. 2019 Mar 13;20(6):
pubmed: 30871134
Sci Adv. 2020 Apr 01;6(14):eaay3245
pubmed: 32270034
J Immunol. 2007 Apr 1;178(7):4615-22
pubmed: 17372020
Br J Dermatol. 2021 Mar;184(3):450-463
pubmed: 33000503
Exp Dermatol. 2012 Jan;21(1):70-2
pubmed: 22082171
Inflamm Res. 2011 Nov;60(11):1031-7
pubmed: 21847628
Nat Med. 2009 Sep;15(9):1013-5
pubmed: 19684581
N Engl J Med. 2016 Aug 4;375(5):422-34
pubmed: 27518661
Dermatology. 2022;238(5):829-836
pubmed: 35537419
Cell Stress Chaperones. 2019 Nov;24(6):1027-1044
pubmed: 31734893
J Exp Med. 2013 Dec 16;210(13):2939-50
pubmed: 24323357
J Dermatol Sci. 2019 Oct;96(1):2-7
pubmed: 31455506
J Invest Dermatol. 2012 Jan;132(1):135-43
pubmed: 21850017
J Invest Dermatol. 2011 Mar;131(3):677-87
pubmed: 21085185
PLoS One. 2013;8(3):e59531
pubmed: 23555696
J Immunol. 2008 Jun 1;180(11):7423-30
pubmed: 18490742
Br J Dermatol. 2018 Aug;179(2):496-498
pubmed: 29432653
Int J Mol Sci. 2021 Nov 23;22(23):
pubmed: 34884474
J Biol Chem. 2012 Mar 23;287(13):9923-9930
pubmed: 22294695
J Immunol. 1995 Jun 1;154(11):6031-9
pubmed: 7751645
N Engl J Med. 2023 Mar 23;388(12):1080-1091
pubmed: 36920778
J Allergy Clin Immunol. 2010 Apr;125(4):858-865.e10
pubmed: 20227751
J Invest Dermatol. 2015 Aug;135(8):2005-2011
pubmed: 25822580
J Invest Dermatol. 2018 Jul;138(7):1555-1563
pubmed: 29474945
Immunol Rev. 2018 Jan;281(1):124-137
pubmed: 29247991
Clin Immunol. 2008 Mar;126(3):332-7
pubmed: 18166499
J Dermatol Sci. 2017 Oct;88(1):57-66
pubmed: 28571749
Immunol Cell Biol. 2015 Oct;93(9):771-9
pubmed: 26303210
Cytokine. 2001 Jan 21;13(2):75-84
pubmed: 11145846
Br J Dermatol. 2014 Sep;171(3):492-8
pubmed: 24601852
Cell Death Dis. 2018 Oct 30;9(11):1104
pubmed: 30377293
Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19455-60
pubmed: 20974963
Immunity. 2019 Apr 16;50(4):832-850
pubmed: 30995502
JID Innov. 2022 Apr 26;2(5):100131
pubmed: 36059592
J Allergy Clin Immunol. 2015 Feb;135(2):553-6
pubmed: 25085340
Sci Transl Med. 2018 Jul 18;10(450):
pubmed: 30021889
Br J Dermatol. 2021 Mar;184(3):437-449
pubmed: 33000465
J Immunol. 2014 Nov 15;193(10):5140-8
pubmed: 25305315
J Allergy Clin Immunol. 2016 Aug;138(2):500-508.e24
pubmed: 27212086
J Allergy Clin Immunol. 2012 Feb;129(2):426-33, 433.e1-8
pubmed: 22177328
Dermatol Ther. 2021 Jul;34(4):e14990
pubmed: 34004074
J Am Acad Dermatol. 2019 Apr;80(4):1013-1021
pubmed: 30550828
N Engl J Med. 2020 Jul 9;383(2):141-150
pubmed: 32640132
Clin Exp Immunol. 2021 Jun;204(3):296-309
pubmed: 33460469
Cytokine. 2020 Aug;132:154605
pubmed: 30527631
Immunol Rev. 2018 Jan;281(1):8-27
pubmed: 29247995
J Invest Dermatol. 2011 Jan;131(1):133-40
pubmed: 20720564
Clin Exp Immunol. 2016 Nov;186(2):144-156
pubmed: 27400195
J Invest Dermatol. 1994 Jul;103(1):92-6
pubmed: 8027587
J Am Acad Dermatol. 2022 Dec;87(6):1380-1383
pubmed: 36116584
Br J Dermatol. 2021 Aug 19;:
pubmed: 34411292
Arthritis Rheum. 2005 Mar;52(3):856-64
pubmed: 15751077
Br J Dermatol. 2022 Jun;186(6):925-941
pubmed: 34990008
Front Immunol. 2018 Sep 25;9:2226
pubmed: 30319661
J Immunol. 2007 Feb 15;178(4):2229-40
pubmed: 17277128
Int J Mol Sci. 2022 Apr 13;23(8):
pubmed: 35457132
Cell Mol Life Sci. 2017 Jul;74(14):2569-2586
pubmed: 28258292
Br J Dermatol. 2021 Sep;185(3):585-594
pubmed: 33792895
J Invest Dermatol. 1998 Oct;111(4):645-9
pubmed: 9764847
N Engl J Med. 2016 Jul 28;375(4):345-56
pubmed: 27299809
Nat Metab. 2021 Oct;3(10):1302-1312
pubmed: 34650277
Rheumatology (Oxford). 2022 Dec 23;62(1):234-242
pubmed: 35583273
J Am Acad Dermatol. 2010 Feb;62(2):205-17
pubmed: 20115947
Cytokine. 2005 Aug 21;31(4):305-13
pubmed: 16023359
Lancet. 2021 Apr 3;397(10281):1301-1315
pubmed: 33812489
Lancet. 2021 Feb 6;397(10273):475-486
pubmed: 33549192
N Engl J Med. 2011 Aug 18;365(7):620-8
pubmed: 21848462
Br J Dermatol. 2022 Oct;187(4):599-602
pubmed: 35481678
J Immunol Res. 2020 Jan 3;2020:5084682
pubmed: 32352019
Eur J Immunol. 2016 Jun;46(6):1343-50
pubmed: 27019190
J Invest Dermatol. 2017 Jan;137(1):115-122
pubmed: 27646883
J Mol Med (Berl). 2009 May;87(5):523-36
pubmed: 19330474
Eur J Immunol. 2016 Mar;46(3):552-9
pubmed: 26634935
Lancet. 2020 Aug 1;396(10247):345-360
pubmed: 32738956
Nat Rev Rheumatol. 2022 Aug;18(8):448-463
pubmed: 35729334
Free Radic Biol Med. 2019 Aug 1;139:80-91
pubmed: 31078730
BioDrugs. 2021 Jul;35(4):401-415
pubmed: 34213742
J Invest Dermatol. 2007 Feb;127(2):331-41
pubmed: 17068485
Nat Med. 2009 Dec;15(12):1377-82
pubmed: 19966777
N Engl J Med. 2015 Oct;373(14):1318-28
pubmed: 26422722
JCI Insight. 2020 Oct 15;5(20):
pubmed: 33055429
Nat Immunol. 2015 May;16(5):448-57
pubmed: 25898198
J Dermatol Sci. 2015 Oct;80(1):45-53
pubmed: 26198442
Immunity. 2004 Aug;21(2):241-54
pubmed: 15308104
J Invest Dermatol. 2005 Jun;124(6):1225-33
pubmed: 15955098
J Allergy Clin Immunol. 2012 Jul;130(1):259-61.e1
pubmed: 22521249
J Allergy Clin Immunol. 2022 Dec;150(6):1517-1524
pubmed: 36041655
J Leukoc Biol. 2018 Nov;104(5):931-951
pubmed: 30066957
Sci Transl Med. 2013 Jan 30;5(170):170ra16
pubmed: 23363980
Immunity. 2019 Apr 16;50(4):812-831
pubmed: 30995501
Eur J Immunol. 2007 Feb;37(2):338-50
pubmed: 17274000
J Clin Med. 2023 Mar 01;12(5):
pubmed: 36902728
J Immunol. 2006 Feb 1;176(3):1431-8
pubmed: 16424170
Immunity. 2005 Jan;22(1):131-42
pubmed: 15664165
Exp Dermatol. 2018 Apr;27(4):327-331
pubmed: 29524262
Nat Immunol. 2012 Jun 24;13(8):753-60
pubmed: 22729249
J Invest Dermatol. 2020 Mar;140(3):636-644.e2
pubmed: 31465744
J Dermatol. 2012 Mar;39(3):225-30
pubmed: 22352846
J Immunol. 2008 Aug 15;181(4):2694-704
pubmed: 18684960
Immunity. 2019 Apr 16;50(4):892-906
pubmed: 30995505
J Immunol. 2002 Jun 1;168(11):5397-402
pubmed: 12023331
Int J Mol Sci. 2022 Aug 22;23(16):
pubmed: 36012744
N Engl J Med. 2002 Oct 10;347(15):1151-60
pubmed: 12374875
J Immunol. 2014 Feb 15;192(4):1815-23
pubmed: 24453242
Lancet. 2017 Jun 10;389(10086):2287-2303
pubmed: 28478972
J Dermatol. 2022 May;49(5):479-487
pubmed: 35243682
Nat Immunol. 2011 Oct 12;12(12):1159-66
pubmed: 21993848
N Engl J Med. 2021 Dec 23;385(26):2431-2440
pubmed: 34936739
J Immunol. 2005 Mar 15;174(6):3695-702
pubmed: 15749908
Nat Med. 2023 May;29(5):1180-1190
pubmed: 37142763
Front Pharmacol. 2023 Jan 16;13:1046687
pubmed: 36726783
Front Immunol. 2018 May 04;9:847
pubmed: 29780381
J Am Acad Dermatol. 2010 Mar;62(3):427-36
pubmed: 20159310
Nat Immunol. 2003 Jan;4(1):69-77
pubmed: 12483210
J Immunol. 1999 Jan 1;162(1):494-502
pubmed: 9886425
J Invest Dermatol. 2014 Nov;134(11):2757-2767
pubmed: 25046339
JAMA Dermatol. 2021 Nov 01;157(11):1279-1288
pubmed: 34406364
Gut. 2006 Apr;55(4):505-9
pubmed: 16188920
J Biol Chem. 1994 Jan 21;269(3):2016-22
pubmed: 7904998
J Invest Dermatol. 2005 Apr;124(4):786-92
pubmed: 15816837
N Engl J Med. 2014 Jul 24;371(4):326-38
pubmed: 25007392
Annu Rev Immunol. 2008;26:57-79
pubmed: 17953510
Eur J Immunol. 2009 Dec;39(12):3570-81
pubmed: 19830738
Science. 2008 May 9;320(5877):807-11
pubmed: 18467591
J Clin Med. 2022 Dec 06;11(23):
pubmed: 36498818
Sci Adv. 2021 Apr 2;7(14):
pubmed: 33811067
Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9021-6
pubmed: 19439663
Immunity. 2005 Nov;23(5):479-90
pubmed: 16286016
J Allergy Clin Immunol. 2020 Jun;145(6):1606-1614.e4
pubmed: 32179159
Immunity. 2015 Jul 21;43(1):15-28
pubmed: 26200010
J Invest Dermatol. 2011 Dec;131(12):2428-37
pubmed: 21881584
Cytokine Growth Factor Rev. 2015 Oct;26(5):545-58
pubmed: 26198770
J Exp Med. 1990 Dec 1;172(6):1609-14
pubmed: 2258696
J Invest Dermatol. 2020 Jul;140(7):1379-1389.e2
pubmed: 31958433
Lancet. 2023 Mar 4;401(10378):747-761
pubmed: 36746171
J Invest Dermatol. 2001 Feb;116(2):330-8
pubmed: 11180011