Non-mucosal vaccination strategies to enhance mucosal immunity.
Journal
Vaccine insights
ISSN: 2752-5422
Titre abrégé: Vaccine Insights
Pays: England
ID NLM: 9918557476006676
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
medline:
26
10
2023
pubmed:
26
10
2023
entrez:
26
10
2023
Statut:
ppublish
Résumé
The SARS-CoV-2 pandemic has highlighted the need for improved vaccines that can elicit long-lasting mucosal immunity. Although mucosal delivery of vaccines represents a plausible method to enhance mucosal immunity, recent studies utilizing intradermal vaccine delivery or incorporation of unique adjuvants suggest that mucosal immunity may be achieved by vaccination via non-mucosal routes. In this expert insight, we highlight emerging evidence from pre-clinical studies that warrant further mechanistic investigation to improve next-generation vaccines against mucosal pathogens, especially those with pandemic potential.
Identifiants
pubmed: 37881504
doi: 10.18609/vac.2023.034
pmc: PMC10599649
mid: NIHMS1921034
doi:
Types de publication
Journal Article
Langues
eng
Pagination
229-236Subventions
Organisme : NIAID NIH HHS
ID : R01 AI166756
Pays : United States
Déclaration de conflit d'intérêts
Morici LA discloses she has the following grants/contracts (HDTRA1–19-C0013; NIH 272201800045C; NIH/NIAID R01 AI166756–01). She receives consulting fees and payment for expert testimony from AP Experts LLC. McLachlan JB discloses he has the following grant/contract (NIH 01AI166756). Lastly, Tulane has an issued patent on vaccine adjuvant technology for which Morici LA and McLachlan JB are inventors.AUTHORSHIP & CONFLICT OF INTEREST
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