Medial Prefrontal Cortex Dysfunction Mediates Working Memory Deficits in Patients With Schizophrenia.
Cognitive deficit
Default mode network
Functional magnetic resonance imaging
Medial prefrontal cortex
Schizophrenia
Working memory
Journal
Biological psychiatry global open science
ISSN: 2667-1743
Titre abrégé: Biol Psychiatry Glob Open Sci
Pays: United States
ID NLM: 9918227369306676
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
15
07
2022
revised:
04
10
2022
accepted:
11
10
2022
medline:
26
10
2023
pubmed:
26
10
2023
entrez:
26
10
2023
Statut:
epublish
Résumé
Schizophrenia (SCZ) is marked by working memory (WM) deficits, which predict poor functional outcome. While most functional magnetic resonance imaging studies of WM in SCZ have focused on the dorsolateral prefrontal cortex (PFC), some recent work suggests that the medial PFC (mPFC) may play a role. We investigated whether task-evoked mPFC deactivation is associated with WM performance and whether it mediates deficits in SCZ. In addition, we investigated associations between mPFC deactivation and cortical dopamine release. Patients with SCZ ( mPFC deactivation was associated with WM task performance, but dorsolateral PFC activation was not. Deactivation in the mPFC was reduced in patients with SCZ relative to HCs and mediated the relationship between diagnosis and WM performance. In addition, mPFC deactivation was significantly and inversely associated with dopamine release capacity across groups and in HCs alone, but not in patients. Reduced WM task-evoked mPFC deactivation is a mediator of, and potential substrate for, WM impairment in SCZ, although our study design does not rule out the possibility that these findings could relate to cognition in general rather than WM specifically. We further present preliminary evidence of an inverse association between deactivation during WM tasks and dopamine release capacity in the mPFC.
Sections du résumé
Background
UNASSIGNED
Schizophrenia (SCZ) is marked by working memory (WM) deficits, which predict poor functional outcome. While most functional magnetic resonance imaging studies of WM in SCZ have focused on the dorsolateral prefrontal cortex (PFC), some recent work suggests that the medial PFC (mPFC) may play a role. We investigated whether task-evoked mPFC deactivation is associated with WM performance and whether it mediates deficits in SCZ. In addition, we investigated associations between mPFC deactivation and cortical dopamine release.
Methods
UNASSIGNED
Patients with SCZ (
Results
UNASSIGNED
mPFC deactivation was associated with WM task performance, but dorsolateral PFC activation was not. Deactivation in the mPFC was reduced in patients with SCZ relative to HCs and mediated the relationship between diagnosis and WM performance. In addition, mPFC deactivation was significantly and inversely associated with dopamine release capacity across groups and in HCs alone, but not in patients.
Conclusions
UNASSIGNED
Reduced WM task-evoked mPFC deactivation is a mediator of, and potential substrate for, WM impairment in SCZ, although our study design does not rule out the possibility that these findings could relate to cognition in general rather than WM specifically. We further present preliminary evidence of an inverse association between deactivation during WM tasks and dopamine release capacity in the mPFC.
Identifiants
pubmed: 37881571
doi: 10.1016/j.bpsgos.2022.10.003
pii: S2667-1743(22)00135-5
pmc: PMC10593895
doi:
Types de publication
Journal Article
Langues
eng
Pagination
990-1002Subventions
Organisme : NIMH NIH HHS
ID : F30 MH122136
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH120293
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH086404
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH107763
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH076544
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008444
Pays : United States
Informations de copyright
© 2022 The Authors.
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