Low Dopamine D2 Receptor Expression Drives Gene Networks Related to GABA, cAMP, Growth and Neuroinflammation in Striatal Indirect Pathway Neurons.
Addiction
Dopamine
Drd2
Indirect pathway
Psychiatric disorders
Substance Use Disorder
TRAP
Transcriptomics
Journal
Biological psychiatry global open science
ISSN: 2667-1743
Titre abrégé: Biol Psychiatry Glob Open Sci
Pays: United States
ID NLM: 9918227369306676
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
18
04
2022
revised:
06
08
2022
accepted:
26
08
2022
medline:
8
9
2022
pubmed:
8
9
2022
entrez:
26
10
2023
Statut:
epublish
Résumé
A salient effect of addictive drugs is to hijack the dopamine reward system, an evolutionarily conserved driver of goal-directed behavior and learning. Reduced dopamine type 2 receptor availability in the striatum is an important pathophysiological mechanism for addiction that is both consequential and causal for other molecular, cellular, and neuronal network differences etiologic for this disorder. Here, we sought to identify gene expression changes attributable to innate low expression of the Cre-conditional, translating ribosome affinity purification (TRAP) was used to purify and analyze the translatome (ribosome-bound messenger RNA) of iMSNs from mice with low/heterozygous or wild-type Innate low expression of This study provides strong molecular evidence that, in addiction, inhibition by the indirect pathway is constitutively enhanced through neural growth and increased GABA signaling.
Sections du résumé
Background
UNASSIGNED
A salient effect of addictive drugs is to hijack the dopamine reward system, an evolutionarily conserved driver of goal-directed behavior and learning. Reduced dopamine type 2 receptor availability in the striatum is an important pathophysiological mechanism for addiction that is both consequential and causal for other molecular, cellular, and neuronal network differences etiologic for this disorder. Here, we sought to identify gene expression changes attributable to innate low expression of the
Methods
UNASSIGNED
Cre-conditional, translating ribosome affinity purification (TRAP) was used to purify and analyze the translatome (ribosome-bound messenger RNA) of iMSNs from mice with low/heterozygous or wild-type
Results
UNASSIGNED
Innate low expression of
Conclusions
UNASSIGNED
This study provides strong molecular evidence that, in addiction, inhibition by the indirect pathway is constitutively enhanced through neural growth and increased GABA signaling.
Identifiants
pubmed: 37881572
doi: 10.1016/j.bpsgos.2022.08.010
pii: S2667-1743(22)00103-3
pmc: PMC10593893
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1104-1115Subventions
Organisme : NIDA NIH HHS
ID : R01 DA033684
Pays : United States
Informations de copyright
© 2022 The Authors.
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