Biological variation of serum neopterin concentrations in apparently healthy individuals.

biological variation index of individuality neopterin reference change value

Journal

Clinical chemistry and laboratory medicine

ISSN: 1437-4331

Titre abrégé: Clin Chem Lab Med

Pays: Germany

ID NLM: 9806306

Informations de publication

Date de publication:
26 Oct 2023

Historique:

received: 23 12 2022

accepted: 17 10 2023

medline: 26 10 2023

pubmed: 26 10 2023

entrez: 26 10 2023

Statut: aheadofprint

Résumé

The aims of this study were to determine the biological variation (BV), reference change value (RCV), index of individuality (II), and quality specifications for serum neopterin concentrations; a measurand provided by clinical laboratories as an indicator of cellular immunity. The study delivered serum samples collected for 10 consecutive weeks from 12 apparently healthy individuals (3 male, 9 female). Serum neopterin concentrations were measured using high-performance liquid chromatography with fluorometric detection. The data analysis was performed using an online statistical tool and addressed published criteria for estimation of biological variation. The mean neopterin concentration was 5.26 nmol/L. The within-subject biological variation (CV This study determined BV data for neopterin, an indicator of cell-mediated immune response. Asymmetric RCV values, of 24.9 % decrease or a 33.1 % increase between consecutive measurements indicate significant change. The II of 0.27 indicates a high degree of individuality, therefore that it is appropriate to consider the use of personal reference data and significance of change rather than the reference interval as points of reference for the evaluation of neopterin serum concentrations.

Identifiants

DOI: 10.1515/cclm-2023-1030 PMID: 37882748

pubmed: 37882748

pii: cclm-2023-1030

doi: 10.1515/cclm-2023-1030

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Informations de copyright

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