Quantitative Analysis of S1PR1 Expression in the Postmortem Multiple Sclerosis Central Nervous System.
S1PR1
[3H]CS1P1
autoradiograph
central nervous system
lesion
multiple sclerosis
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
15 11 2023
15 11 2023
Historique:
medline:
16
11
2023
pubmed:
26
10
2023
entrez:
26
10
2023
Statut:
ppublish
Résumé
Multiple sclerosis (MS) is an immune-mediated disease that is characterized by demyelination and inflammation in the central nervous system (CNS). Previous studies demonstrated that sphingosine-1-phosphate receptor (S1PR) modulators effectively inhibit S1PR1 in immune cell trafficking and reduce entry of pathogenic cells into the CNS. Studies have also implicated a nonimmune, inflammatory role of S1PR1 within the CNS in MS. In this study, we explored the expression of S1PR1 in the development and progression of demyelinating pathology of MS by quantitative assessment of S1PR1 expression using our S1PR1-specific radioligand, [
Identifiants
pubmed: 37882753
doi: 10.1021/acschemneuro.3c00581
doi:
Substances chimiques
Receptors, Lysosphingolipid
0
S1PR1 protein, human
0
Sphingosine-1-Phosphate Receptors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
4039-4050Subventions
Organisme : NINDS NIH HHS
ID : R01 NS103988
Pays : United States