The interdependence of isoprenoid synthesis and apicoplast biogenesis in malaria parasites.
Journal
PLoS pathogens
ISSN: 1553-7374
Titre abrégé: PLoS Pathog
Pays: United States
ID NLM: 101238921
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
medline:
30
10
2023
pubmed:
26
10
2023
entrez:
26
10
2023
Statut:
epublish
Résumé
Isoprenoid precursor synthesis is an ancient and fundamental function of plastid organelles and a critical metabolic activity of the apicoplast in Plasmodium malaria parasites [1-3]. Over the past decade, our understanding of apicoplast properties and functions has increased enormously [4], due in large part to our ability to rescue blood-stage parasites from apicoplast-specific dysfunctions by supplementing cultures with isopentenyl pyrophosphate (IPP), a key output of this organelle [5,6]. In this Pearl, we explore the interdependence between isoprenoid metabolism and apicoplast biogenesis in P. falciparum and highlight critical future questions to answer.
Identifiants
pubmed: 37883328
doi: 10.1371/journal.ppat.1011713
pii: PPATHOGENS-D-23-01012
pmc: PMC10602226
doi:
Substances chimiques
Protozoan Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1011713Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM133764
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI055434
Pays : United States
Informations de copyright
Copyright: © 2023 Okada, Sigala. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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