Urinary lumirubin excretion in jaundiced preterm neonates during phototherapy with blue light-emitting diode vs. green fluorescent lamp.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
26 10 2023
26 10 2023
Historique:
received:
02
08
2023
accepted:
16
10
2023
medline:
30
10
2023
pubmed:
27
10
2023
entrez:
26
10
2023
Statut:
epublish
Résumé
Phototherapy converts lipophilic unconjugated bilirubin to hydrophilic bilirubin photoisomers, such as lumirubin. We comparatively used a blue light-emitting diode (LED) and a green fluorescent lamp (FL) as light sources for phototherapy of hyperbilirubinemic preterm neonates with the aim of examining potential differences in urinary lumirubin excretion between these two wavelengths. Urinary lumirubin levels were measured using a fluorescence assay with blue light exposure in the presence of the unconjugated bilirubin-inducible fluorescent protein UnaG, and denoted as urinary UnaG-bound bilirubin (UUB)/creatinine (Cr) (μg/mg Cr). Preterm neonates born at ≤ 33 weeks gestational age and treated with phototherapy were subjected to this study. The maximum UUB/Cr level during phototherapy per device intensity was compared between neonates treated with the blue LED and the green FL. A total of 61 neonates were examined to determine the maximum UUB/Cr levels. The median of maximum UUB/Cr excretion per light intensity of each device (μg/mg Cr/μW/cm
Identifiants
pubmed: 37884564
doi: 10.1038/s41598-023-45147-7
pii: 10.1038/s41598-023-45147-7
pmc: PMC10603030
doi:
Substances chimiques
lumirubin
83664-21-5
Bilirubin
RFM9X3LJ49
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18359Informations de copyright
© 2023. The Author(s).
Références
Am J Cardiol. 2001 May 15;87(10):1196-200; A4, 7
pubmed: 11356398
Photochem Photobiol. 1991 Jan;53(1):25-32
pubmed: 2027905
Sci Rep. 2018 May 10;8(1):7444
pubmed: 29748620
Pediatr Res. 2015 Aug;78(2):223-30
pubmed: 25950455
Pediatr Res. 2016 Oct;80(4):511-5
pubmed: 27331354
Cell. 2013 Jun 20;153(7):1602-11
pubmed: 23768684
Pediatrics. 2016 Jun;137(6):
pubmed: 27217478
Comp Med. 2009 Jun;59(3):287-96
pubmed: 19619420
Sci Rep. 2022 Jul 12;12(1):11798
pubmed: 35821401
Pediatrics. 2022 Sep 1;150(3):
pubmed: 35927462
Pediatr Res. 2019 May;85(6):865-873
pubmed: 30710116
J Hepatol. 2021 Dec;75(6):1485-1490
pubmed: 34153399
J Matern Fetal Neonatal Med. 2005 Aug;18(2):129-31
pubmed: 16203599
Clin Perinatol. 2016 Jun;43(2):259-76
pubmed: 27235206
Pediatrics. 2016 Oct;138(4):
pubmed: 27669736
J Biochem. 1986 Sep;100(3):789-95
pubmed: 3782069
Acta Diabetol. 2012 Feb;49(1):83-7
pubmed: 21984049
Pediatr Res. 1985 Feb;19(2):198-201
pubmed: 3982878
N Engl J Med. 2008 Oct 30;359(18):1885-96
pubmed: 18971491