Programmable late-stage functionalization of bridge-substituted bicyclo[1.1.1]pentane bis-boronates.
Journal
Nature chemistry
ISSN: 1755-4349
Titre abrégé: Nat Chem
Pays: England
ID NLM: 101499734
Informations de publication
Date de publication:
26 Oct 2023
26 Oct 2023
Historique:
received:
11
04
2022
accepted:
08
09
2023
medline:
27
10
2023
pubmed:
27
10
2023
entrez:
26
10
2023
Statut:
aheadofprint
Résumé
Modular functionalization enables versatile exploration of chemical space and has been broadly applied in structure-activity relationship (SAR) studies of aromatic scaffolds during drug discovery. Recently, the bicyclo[1.1.1]pentane (BCP) motif has increasingly received attention as a bioisosteric replacement of benzene rings due to its ability to improve the physicochemical properties of prospective drug candidates, but studying the SARs of C
Identifiants
pubmed: 37884667
doi: 10.1038/s41557-023-01342-7
pii: 10.1038/s41557-023-01342-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Foundation (NSF)
ID : CAREER CHE-2143925
Organisme : Welch Foundation
ID : I-2010-20190330
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R01GM141088
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R35GM137797
Organisme : ACS | American Chemical Society Petroleum Research Fund (ACS Petroleum Research Fund)
ID : 62223-DNI1
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Limited.
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