Ring-Opening Reactions of Phosphoramidate Heterocycles.


Journal

Tetrahedron
ISSN: 0040-4020
Titre abrégé: Tetrahedron
Pays: England
ID NLM: 2984170R

Informations de publication

Date de publication:
12 May 2023
Historique:
medline: 27 10 2023
pubmed: 27 10 2023
entrez: 27 10 2023
Statut: ppublish

Résumé

We present protocols for the conversion of phosphoramidate heterocycles into 1,3-chloroamines and 1,3-aminoalcohols. For the formation of chloroamines, our optimized protocol involves heating the phosphoramidate starting material with 4 equivalents of HCl in a dioxane/toluene solvent mixture. The substituents on the phosphoramidate starting material have a profound influence on product formation. Phosphoramidates with a variety of

Identifiants

pubmed: 37885946
doi: 10.1016/j.tet.2023.133390
pmc: PMC10602049
mid: NIHMS1893778
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM142499
Pays : United States

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Auteurs

Annu Anna Thomas (AA)

Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas, 66047, USA.

Frederick J Seidl (FJ)

Independent Researcher, San Mateo, California, 94402, USA.

Joel T Mague (JT)

Department of Chemistry, Tulane University, New Orleans, Louisiana, 70118, USA.

Shyam Sathyamoorthi (S)

Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas, 66047, USA.

Classifications MeSH