Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic Architecture.
Cortex
Cortical Surface Area
Cortical Thickness
Genetically Informed Brain Networks
Genome Wide Association Study (GWAS)
Genomic Structural Equation Modeling (gSEM)
pleiotropy
structural covariance networks (SCN)
Journal
Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035
Informations de publication
Date de publication:
03 Oct 2023
03 Oct 2023
Historique:
pubmed:
27
10
2023
medline:
27
10
2023
entrez:
27
10
2023
Statut:
epublish
Résumé
Genetic contributions to human cortical structure manifest pervasive pleiotropy. This pleiotropy may be harnessed to identify unique genetically-informed parcellations of the cortex that are neurobiologically distinct from functional, cytoarchitectural, or other cortical parcellation schemes. We investigated genetic pleiotropy by applying genomic structural equation modeling (SEM) to map the genetic architecture of cortical surface area (SA) and cortical thickness (CT) for the 34 brain regions recently reported in the ENIGMA cortical GWAS. Genomic SEM uses the empirical genetic covariance estimated from GWAS summary statistics with LD score regression (LDSC) to discover factors underlying genetic covariance, which we are denoting
Identifiants
pubmed: 37886496
doi: 10.21203/rs.3.rs-3253035/v1
pmc: PMC10602057
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIMH NIH HHS
ID : K23 MH073091
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH111671
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH116147
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : CSRD VA
ID : IK2 CX002107
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG058854
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH106595
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH129832
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015922
Pays : United States
Organisme : RRD VA
ID : I01 RX000389
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS086885
Pays : United States
Organisme : CSRD VA
ID : I01 CX000748
Pays : United States
Déclaration de conflit d'intérêts
Dr. Thompson received partial research support from Biogen, Inc. (Boston, USA) for research unrelated to the topic of this manuscript. No other authors have competing financial interests in relation to the research presented herein. The material presented is original research that has not been previously published and has not been submitted for publication elsewhere.
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