Natural Killer Repertoire Restoration in TB/HIV Co-Infected Individuals Experienced an Immune Reconstitution Syndrome (CAMELIA Trial, ANRS 12153).
HIV
NK cells
antiretroviral treatment
immune reconstitution
immune reconstitution inflammatory syndrome
tuberculosis
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
13 Oct 2023
13 Oct 2023
Historique:
received:
25
08
2023
revised:
06
10
2023
accepted:
07
10
2023
medline:
27
10
2023
pubmed:
27
10
2023
entrez:
27
10
2023
Statut:
epublish
Résumé
IRIS is a common complication in HIV-infected patients treated for tuberculosis (TB) and cART. Our aim was to evaluate NK cell reconstitution in HIV-infected patients with TB-IRIS compared to those without IRIS. 147 HIV-infected patients with TB from the CAMELIA trial were enrolled. HIV+TB+ patients were followed for 32 weeks. The NK cell repertoire was assessed in whole blood at different time points. As CAMELIA has two arms (early and late cART initiation), we analysed them separately. At enrolment, individuals had low CD4 cell counts (27 cells/mm
Identifiants
pubmed: 37887757
pii: pathogens12101241
doi: 10.3390/pathogens12101241
pmc: PMC10610037
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : ANRS
ID : 12153
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