High-Precision 3D Printing of Microporous Cochlear Implants for Personalized Local Drug Delivery.
cytocompatibility
hearing loss
porous cochlear implant
surface quality
two-photon polymerization
Journal
Journal of functional biomaterials
ISSN: 2079-4983
Titre abrégé: J Funct Biomater
Pays: Switzerland
ID NLM: 101570734
Informations de publication
Date de publication:
03 Oct 2023
03 Oct 2023
Historique:
received:
04
09
2023
revised:
28
09
2023
accepted:
30
09
2023
medline:
27
10
2023
pubmed:
27
10
2023
entrez:
27
10
2023
Statut:
epublish
Résumé
Hearing loss is a highly prevalent multifactorial disorder affecting 20% of the global population. Current treatments using the systemic administration of drugs are therapeutically ineffective due to the anatomy of the cochlea and the existing blood-labyrinth barrier. Local drug delivery systems can ensure therapeutic drug concentrations locally while preventing adverse effects caused by high dosages of systemically administered drugs. Here, we aimed to design, fabricate, and characterize a local drug delivery system for the human cochlea. The design was relevant to the size of the human ear, included two different shapes, and incorporated two different microporous structures acting as reservoirs for drug loading and release. The four cochlear implant designs were printed using the two-photon polymerization (2PP) technique and the IP-Q photoresist. The optimized 2PP process enabled the fabrication of the cochlear implants with great reproducibility and shape fidelity. Rectangular and cylindrical implants featuring cylindrical and tapered tips, respectively, were successfully printed. Their outer dimensions were 0.6 × 0.6 × 2.4 mm
Identifiants
pubmed: 37888159
pii: jfb14100494
doi: 10.3390/jfb14100494
pmc: PMC10607433
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Interreg 2Seas
ID : Site Drug 2S07-033
Références
Laryngoscope. 2005 Nov;115(11):2000-5
pubmed: 16319613
Biofabrication. 2019 Apr 26;11(3):035014
pubmed: 30933941
J Control Release. 2012 Apr 10;159(1):60-8
pubmed: 22233971
J Control Release. 2023 Jan;353:864-874
pubmed: 36464064
Front Bioeng Biotechnol. 2022 Feb 11;9:809443
pubmed: 35223817
Bioact Mater. 2023 Aug 04;31:18-37
pubmed: 37593495
Hear Res. 2010 Jun 14;265(1-2):25-9
pubmed: 20303400
Opt Lett. 1995 Mar 1;20(5):435-7
pubmed: 19859212
Int J Pharm X. 2022 Nov 22;4:100141
pubmed: 36465275
Dent Mater. 2006 Apr;22(4):359-65
pubmed: 16143380
Acta Biomater. 2011 Jun;7(6):2644-50
pubmed: 21402182
J Biomater Sci Polym Ed. 2023 Aug 21;:1-24
pubmed: 37566099
Opt Lett. 2014 May 15;39(10):3034-7
pubmed: 24978266
Adv Healthc Mater. 2019 Oct;8(20):e1900379
pubmed: 31532887
Nanoscale. 2016 Mar 14;8(10):5764-70
pubmed: 26910437
Acta Biomater. 2013 Jul;9(7):7354-61
pubmed: 23454055
Int J Pharm X. 2019 May 21;1:100015
pubmed: 31517280
J Biomed Mater Res. 1999;48(5):675-81
pubmed: 10490681
J Control Release. 2020 Jun 10;322:42-52
pubmed: 32145267
Drug Deliv. 2023 Dec;30(1):51-63
pubmed: 36474425
Microsyst Nanoeng. 2021 Sep 3;7:71
pubmed: 34567783
Chem Rev. 2008 Apr;108(4):1245-330
pubmed: 18361528
Otol Neurotol. 2019 Jun;40(5):617-624
pubmed: 31083083
Int J Pharm. 2019 Aug 15;567:118497
pubmed: 31279771
IEEE Trans Nanobioscience. 2023 Apr;22(2):237-244
pubmed: 35737616
J Dent. 1997 Nov;25(6):435-40
pubmed: 9604575
Acta Otolaryngol. 2015 Aug;135(8):791-8
pubmed: 25813859
Ear Hear. 2010 Apr;31(2):156-65
pubmed: 19952751
Polymers (Basel). 2017 Apr 29;9(5):
pubmed: 30970839
Am J Otol. 1999 Jan;20(1):87-90
pubmed: 9918180
ACS Nano. 2018 Sep 25;12(9):9617-9625
pubmed: 30203963
Nanoscale. 2021 Sep 2;13(34):14304-14315
pubmed: 34190291
Eur Rev Med Pharmacol Sci. 2020 Aug;24(15):7946-7952
pubmed: 32767320
Adv Drug Deliv Rev. 2021 Jul;174:553-575
pubmed: 33965461
Int J Pharm. 2008 Dec 8;364(2):328-43
pubmed: 18822362
J Clin Med. 2021 Jul 28;10(15):
pubmed: 34362099
Eur J Pharm Sci. 2010 Jan 31;39(1-3):110-5
pubmed: 19931387
Biomaterials. 2020 Feb;230:119618
pubmed: 31757530
Pharmaceutics. 2020 Nov 17;12(11):
pubmed: 33212847
Front Bioeng Biotechnol. 2022 Jul 22;10:926642
pubmed: 35979173
Front Cell Neurosci. 2019 Jun 03;13:238
pubmed: 31213983
AAPS PharmSciTech. 2022 Jul 14;23(6):196
pubmed: 35835970
Hear Res. 2011 Feb;272(1-2):168-77
pubmed: 20969940
Otolaryngol Clin North Am. 2020 Feb;53(1):87-102
pubmed: 31677740
Micromachines (Basel). 2023 Aug 14;14(8):
pubmed: 37630138
Acta Biomater. 2015 Apr;16:145-55
pubmed: 25653217
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Int J Pharm. 2016 Jul 25;509(1-2):85-94
pubmed: 27050866
Int J Pharm. 2017 Aug 30;529(1-2):285-293
pubmed: 28668582
Regen Biomater. 2023 Feb 07;10:rbad008
pubmed: 36911146
Int J Pharm. 2017 Sep 15;530(1-2):71-78
pubmed: 28750894
Nat Commun. 2019 May 16;10(1):2179
pubmed: 31097713
J Photochem Photobiol B. 2022 Apr;229:112424
pubmed: 35276580