The Application of a Physiologically Based Toxicokinetic Model in Health Risk Assessment.
PBTK model
compartmental model
exposure routes
health risk assessment
Journal
Toxics
ISSN: 2305-6304
Titre abrégé: Toxics
Pays: Switzerland
ID NLM: 101639637
Informations de publication
Date de publication:
21 Oct 2023
21 Oct 2023
Historique:
received:
13
09
2023
revised:
17
10
2023
accepted:
19
10
2023
medline:
27
10
2023
pubmed:
27
10
2023
entrez:
27
10
2023
Statut:
epublish
Résumé
Toxicokinetics plays a crucial role in the health risk assessments of xenobiotics. Classical compartmental models are limited in their ability to determine chemical concentrations in specific organs or tissues, particularly target organs or tissues, and their limited interspecific and exposure route extrapolation hinders satisfactory health risk assessment. In contrast, physiologically based toxicokinetic (PBTK) models quantitatively describe the absorption, distribution, metabolism, and excretion of chemicals across various exposure routes and doses in organisms, establishing correlations with toxic effects. Consequently, PBTK models serve as potent tools for extrapolation and provide a theoretical foundation for health risk assessment and management. This review outlines the construction and application of PBTK models in health risk assessment while analyzing their limitations and future perspectives.
Identifiants
pubmed: 37888724
pii: toxics11100874
doi: 10.3390/toxics11100874
pmc: PMC10611306
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Natural Science Foundation of China
ID : 82104520, 82174068
Organisme : Natural Science Foundation of Fujian Province
ID : 2021J05045
Organisme : Fujian Medical University High-level Talent Research Startup Funding Project
ID : XRCZX2020014
Organisme : Open Research Fund of Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education
ID : FMUGIC-202101
Organisme : Startup Fund for Scientific Research of Fujian Medical University
ID : 2021QH1004
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