Freeze-Induced Phase Transition and Local Pressure in a Phospholipid/Water System: Novel Insights Were Obtained from a Time/Temperature Resolved Synchrotron X-ray Diffraction Study.
freeze-induced pressure
freezing
ice
phospholipids
small-angle X-ray scattering
synchrotron X-ray
Journal
Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791
Informations de publication
Date de publication:
06 11 2023
06 11 2023
Historique:
medline:
7
11
2023
pubmed:
27
10
2023
entrez:
27
10
2023
Statut:
ppublish
Résumé
Water-to-ice transformation results in a 10% increase in volume, which can have a significant impact on biopharmaceuticals during freeze-thaw cycles due to the mechanical stresses imparted by the growing ice crystals. Whether these stresses would contribute to the destabilization of biopharmaceuticals depends on both the magnitude of the stress and sensitivity of a particular system to pressure and sheer stresses. To address the gap of the "magnitude" question, a phospholipid, 1,2-dipalmitoyl-
Identifiants
pubmed: 37889088
doi: 10.1021/acs.molpharmaceut.3c00657
pmc: PMC10630958
doi:
Substances chimiques
Water
059QF0KO0R
Phospholipids
0
Ice
0
1,2-Dipalmitoylphosphatidylcholine
2644-64-6
Biological Products
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5790-5799Références
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