The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases.

Humans alpha-Synuclein / metabolism Multiple System Atrophy / metabolism Parkinson Disease / metabolism Positron-Emission Tomography

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
27 10 2023
Historique:
received: 17 05 2023
accepted: 06 10 2023
medline: 30 10 2023
pubmed: 28 10 2023
entrez: 27 10 2023
Statut: epublish

Résumé

A positron emission tomography (PET) tracer detecting α-synuclein pathology will improve the diagnosis, and ultimately the treatment of α-synuclein-related diseases. Here we show that the PET ligand, [

Identifiants

DOI: 10.1038/s41467-023-42305-3 PMID: 37891183 PMC: PMC10611796
pubmed: 37891183
doi: 10.1038/s41467-023-42305-3
pii: 10.1038/s41467-023-42305-3
pmc: PMC10611796
doi:

Substances chimiques

alpha-Synuclein 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6750

Subventions

Organisme : NIA NIH HHS
ID : P30 AG019610
Pays : United States
Organisme : NINDS NIH HHS
ID : U24 NS072026
Pays : United States

Informations de copyright

© 2023. Springer Nature Limited.

Références

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Auteurs

Ruben Smith (R)

Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
Department of Neurology, Skåne University Hospital, Lund, Sweden.
ORCID: 0000-0001-7147-0112

Francesca Capotosti (F)

AC Immune SA, EPFL Innovation Park, Building B, 1015, Lausanne, Switzerland.
ORCID: 0000-0003-2819-3206

Martin Schain (M)

Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
Antaros Medical, Mölndal, Sweden.
Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark.

Tomas Ohlsson (T)

Department of Radiation Physics, Skånes University Hospital, Lund, Sweden.

Efthymia Vokali (E)

AC Immune SA, EPFL Innovation Park, Building B, 1015, Lausanne, Switzerland.

Jerome Molette (J)

AC Immune SA, EPFL Innovation Park, Building B, 1015, Lausanne, Switzerland.
ORCID: 0009-0000-5381-5535

Tanja Touilloux (T)

AC Immune SA, EPFL Innovation Park, Building B, 1015, Lausanne, Switzerland.

Valerie Hliva (V)

AC Immune SA, EPFL Innovation Park, Building B, 1015, Lausanne, Switzerland.
ORCID: 0000-0002-1252-0033

Ioannis K Dimitrakopoulos (IK)

AC Immune SA, EPFL Innovation Park, Building B, 1015, Lausanne, Switzerland.

Andreas Puschmann (A)

Department of Neurology, Skåne University Hospital, Lund, Sweden.
Neurology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
SciLifeLab National Research Infrastructure, Lund University, Lund, Sweden.

Jonas Jögi (J)

Department of Clinical Physiology and Nuclear Medicine, Skåne University Hospital, Lund, Sweden.

Per Svenningsson (P)

Department of Neurology, Academic Specialist Center, Karolinska University Hospital, Stockholm, Sweden.
ORCID: 0000-0001-6727-3802

Mattias Andréasson (M)

Department of Neurology, Academic Specialist Center, Karolinska University Hospital, Stockholm, Sweden.

Christine Sandiego (C)

Invicro, LLC, New Haven, CT, USA.

David S Russell (DS)

Invicro, LLC, New Haven, CT, USA.
ORCID: 0000-0002-9105-2943

Patricia Miranda-Azpiazu (P)

Clinical Neuroscience, PET Division, Karolinska Institute, Stockholm, Sweden.

Christer Halldin (C)

Clinical Neuroscience, PET Division, Karolinska Institute, Stockholm, Sweden.

Erik Stomrud (E)

Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
Memory Clinic, Skåne University Hospital, Lund, Sweden.

Sara Hall (S)

Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
Memory Clinic, Skåne University Hospital, Lund, Sweden.
ORCID: 0000-0001-6585-9105

Klas Bratteby (K)

Department of Radiation Physics, Skånes University Hospital, Lund, Sweden.
ORCID: 0000-0003-0930-2390

Elina Tampio L'Estrade (E)

Department of Radiation Physics, Skånes University Hospital, Lund, Sweden.

Ruth Luthi-Carter (R)

AC Immune SA, EPFL Innovation Park, Building B, 1015, Lausanne, Switzerland.

Andrea Pfeifer (A)

AC Immune SA, EPFL Innovation Park, Building B, 1015, Lausanne, Switzerland.

Marie Kosco-Vilbois (M)

AC Immune SA, EPFL Innovation Park, Building B, 1015, Lausanne, Switzerland.

Johannes Streffer (J)

AC Immune SA, EPFL Innovation Park, Building B, 1015, Lausanne, Switzerland. johannes.streffer@uantwerpen.be.
Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. johannes.streffer@uantwerpen.be.
ORCID: 0000-0002-9387-5951

Oskar Hansson (O)

Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden. Oskar.Hansson@med.lu.se.
Memory Clinic, Skåne University Hospital, Lund, Sweden. Oskar.Hansson@med.lu.se.
ORCID: 0000-0001-8467-7286

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The α-synuclein PET tracer [18F] ACI-12589...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › alpha-Synucléine › The α-synuclein PET tracer [18F] ACI-12589...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Atrophie multisystématisée › The α-synuclein PET tracer [18F] ACI-12589...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › The α-synuclein PET tracer [18F] ACI-12589...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › The α-synuclein PET tracer [18F] ACI-12589...