CRISPR-Cas system to discover host-virus interactions in Flaviviridae.
Antiviral strategy
CRISPR KO
CRISPR/Cas
Flaviviridae pathogenesis
Flavivirus
Genome editing
Genome-wide CRISPR screens
Host factors
Virus-host interactions
Journal
Virology journal
ISSN: 1743-422X
Titre abrégé: Virol J
Pays: England
ID NLM: 101231645
Informations de publication
Date de publication:
27 10 2023
27 10 2023
Historique:
received:
10
03
2023
accepted:
25
10
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
27
10
2023
Statut:
epublish
Résumé
The Flaviviridae virus family members cause severe human diseases and are responsible for considerable mortality and morbidity worldwide. Therefore, researchers have conducted genetic screens to enhance insight into viral dependency and develop potential anti-viral strategies to treat and prevent these infections. The host factors identified by the clustered regularly interspaced short palindromic repeats (CRISPR) system can be potential targets for drug development. Meanwhile, CRISPR technology can be efficiently used to treat viral diseases as it targets both DNA and RNA. This paper discusses the host factors related to the life cycle of viruses of this family that were recently discovered using the CRISPR system. It also explores the role of immune factors and recent advances in gene editing in treating flavivirus-related diseases. The ever-increasing advancements of this technology may promise new therapeutic approaches with unique capabilities, surpassing the traditional methods of drug production and treatment.
Identifiants
pubmed: 37891676
doi: 10.1186/s12985-023-02216-7
pii: 10.1186/s12985-023-02216-7
pmc: PMC10605781
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
247Informations de copyright
© 2023. The Author(s).
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