The Genetic Background of Abnormalities in Metabolic Pathways of Phosphoinositides and Their Linkage with the Myotubular Myopathies, Neurodegenerative Disorders, and Carcinogenesis.
X-linked myotubular myopathy
carcinogenesis
myo-inositol
myotubular myopathy
neurodegenerative disorders
phosphatidylinositol
phosphatidylinositol phosphate
phosphoinositides
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
19 10 2023
19 10 2023
Historique:
received:
27
08
2023
revised:
16
09
2023
accepted:
16
10
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
Myo-inositol belongs to one of the sugar alcohol groups known as cyclitols. Phosphatidylinositols are one of the derivatives of Myo-inositol, and constitute important mediators in many intracellular processes such as cell growth, cell differentiation, receptor recycling, cytoskeletal organization, and membrane fusion. They also have even more functions that are essential for cell survival. Mutations in genes encoding phosphatidylinositols and their derivatives can lead to many disorders. This review aims to perform an in-depth analysis of these connections. Many authors emphasize the significant influence of phosphatidylinositols and phosphatidylinositols' phosphates in the pathogenesis of myotubular myopathies, neurodegenerative disorders, carcinogenesis, and other less frequently observed diseases. In our review, we have focused on three of the most often mentioned groups of disorders. Inositols are the topic of many studies, and yet, there are no clear results of successful clinical trials. Analysis of the available literature gives promising results and shows that further research is still needed.
Identifiants
pubmed: 37892232
pii: biom13101550
doi: 10.3390/biom13101550
pmc: PMC10605126
pii:
doi:
Substances chimiques
Phosphatidylinositols
0
Inositol
4L6452S749
Phosphatidylinositol Phosphates
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
PLoS One. 2008;3(11):e3734
pubmed: 19011688
Plant Physiol. 2009 Dec;151(4):1812-22
pubmed: 19846542
J Biol Chem. 1998 May 29;273(22):13375-8
pubmed: 9593664
Int J Clin Exp Pathol. 2018 Apr 01;11(4):1999-2007
pubmed: 31938306
Mamm Genome. 2010 Oct;21(9-10):458-66
pubmed: 20872266
Hum Mutat. 2013 Sep;34(9):1208-15
pubmed: 23804577
Mol Biol Cell. 2005 May;16(5):2218-33
pubmed: 15716355
Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17518-23
pubmed: 17956977
Cold Spring Harb Perspect Biol. 2017 Jul 5;9(7):
pubmed: 28062563
Nat Immunol. 2020 Aug;21(8):868-879
pubmed: 32690950
Biochem Biophys Res Commun. 2013 Oct 18;440(2):277-82
pubmed: 24070612
Haematologica. 2020 Jun;105(6):1641-1649
pubmed: 31582538
Biochem Soc Trans. 2009 Oct;37(Pt 5):1139-43
pubmed: 19754467
Cell. 2019 Jan 10;176(1-2):11-42
pubmed: 30633901
Biochim Biophys Acta Mol Cell Res. 2018 Jul 30;:
pubmed: 30071275
Autophagy. 2007 May-Jun;3(3):222-9
pubmed: 17297299
Nat Commun. 2014 Mar 28;5:3552
pubmed: 24675427
Nature. 2010 May 27;465(7297):497-501
pubmed: 20463662
Cancer Res. 1997 Jun 1;57(11):2124-9
pubmed: 9187108
Traffic. 2005 Sep;6(9):711-9
pubmed: 16101675
Traffic. 2014 May;15(5):471-87
pubmed: 24499450
Cell Struct Funct. 2017 May 3;42(1):49-60
pubmed: 28302928
J Biol Chem. 2013 Jan 11;288(2):1009-21
pubmed: 23188820
Brain. 2016 Sep;139(Pt 9):2420-30
pubmed: 27435091
Oncogene. 2010 Feb 4;29(5):687-97
pubmed: 19915616
Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Aug;1867(8):159161
pubmed: 35427794
PLoS Genet. 2013 Jun;9(6):e1003583
pubmed: 23818870
Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C436-46
pubmed: 22621786
Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19524-9
pubmed: 17158800
Sci Transl Med. 2014 Jan 22;6(220):220ra10
pubmed: 24452262
Cancer Cell. 2009 Aug 4;16(2):115-25
pubmed: 19647222
Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10461-6
pubmed: 26240347
Oncogenesis. 2020 Jun 10;9(6):59
pubmed: 32522977
PLoS Pathog. 2019 Feb 7;15(2):e1007551
pubmed: 30730983
J Med Chem. 2022 Feb 24;65(4):3359-3370
pubmed: 35148092
Expert Rev Clin Pharmacol. 2020 Aug;13(8):813-823
pubmed: 32576028
Cancer Res. 2005 May 15;65(10):4108-16
pubmed: 15899801
Eur J Biochem. 1990 Oct 5;193(1):1-18
pubmed: 2171926
Nutrients. 2023 Apr 23;15(9):
pubmed: 37432155
Nature. 2003 Oct 16;425(6959):737-41
pubmed: 14562106
PLoS Genet. 2018 Mar 27;14(3):e1007290
pubmed: 29584722
PLoS One. 2013 Oct 03;8(10):e76405
pubmed: 24098492
Neuromuscul Disord. 2021 Oct;31(10):1004-1012
pubmed: 34736623
Ann Hum Genet. 2008 May;72(Pt 3):416-41
pubmed: 18215208
J Biol Chem. 2019 May 24;294(21):8412-8423
pubmed: 30944173
Biochem J. 2019 Jan 7;476(1):1-23
pubmed: 30617162
N Engl J Med. 2014 Mar 13;370(11):1061-2
pubmed: 24620870
J Biol Chem. 2009 Jan 23;284(4):2064-71
pubmed: 19038970
Toxicol Sci. 2018 Oct 1;165(2):272-276
pubmed: 30629266
J Biol Chem. 1999 Jul 30;274(31):21589-97
pubmed: 10419465
PLoS Biol. 2012 Jan;10(1):e1001245
pubmed: 22272187
Neurol Genet. 2016 Mar 03;2(2):e61
pubmed: 27123480
Ageing Res Rev. 2008 Jul;7(3):234-48
pubmed: 18657484
Int J Nanomedicine. 2016 Oct 11;11:5257-5276
pubmed: 27785026
Dev Cell. 2016 Sep 12;38(5):536-47
pubmed: 27623384
Blood. 2017 Mar 30;129(13):1768-1778
pubmed: 28104689
Nat Cell Biol. 2013 Dec;15(12):1486-1494
pubmed: 24270891
Cancer Res. 2007 Oct 1;67(19):9229-37
pubmed: 17909029
Acta Crystallogr D Biol Crystallogr. 2015 Jul;71(Pt 7):1528-39
pubmed: 26143924
J Biol Chem. 1995 Apr 21;270(16):9370-7
pubmed: 7721860
Curr Biol. 2001 Oct 16;11(20):1600-5
pubmed: 11676921
Assay Drug Dev Technol. 2017 Jul;15(5):210-219
pubmed: 28723271
EMBO Mol Med. 2019 Jun;11(6):
pubmed: 31015277
Nat Rev Nephrol. 2017 Aug;13(8):455-470
pubmed: 28669993
Cell. 2002 May 31;109(5):599-610
pubmed: 12062103
Biochem J. 2001 Dec 1;360(Pt 2):277-83
pubmed: 11716755
Cell. 2017 Aug 10;170(4):605-635
pubmed: 28802037
Cell. 2002 May 31;109(5):611-23
pubmed: 12062104
Semin Cell Dev Biol. 2001 Apr;12(2):183-91
pubmed: 11292384
Curr Biol. 2003 Mar 18;13(6):504-9
pubmed: 12646134
J Biol Chem. 2007 Aug 17;282(33):23878-91
pubmed: 17556371
Int J Mol Sci. 2017 Mar 15;18(3):
pubmed: 28294977
Onco Targets Ther. 2019 Oct 09;12:8287-8299
pubmed: 31632078
Oncogene. 2020 Jan;39(4):801-813
pubmed: 31554935
Eur J Med Chem. 2023 Feb 5;247:115027
pubmed: 36584631
Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9539-44
pubmed: 22647598
Oncotarget. 2016 Aug 2;7(31):50490-50506
pubmed: 27409167
Expert Rev Mol Med. 2007 Sep 20;9(25):1-16
pubmed: 17880751
Biophys J. 2008 Oct;95(8):4057-67
pubmed: 18676656
Biochem J. 2009 Apr 1;419(1):57-63
pubmed: 19125695
J Biol Chem. 2004 Apr 2;279(14):13817-24
pubmed: 14722070
Mol Biol Cell. 2001 Aug;12(8):2396-411
pubmed: 11514624
Expert Opin Drug Metab Toxicol. 2016 Oct;12(10):1181-96
pubmed: 27351907
Nat Rev Clin Oncol. 2018 May;15(5):273-291
pubmed: 29508857
J Cell Sci. 2007 Aug 1;120(Pt 15):2517-31
pubmed: 17623773
Bioessays. 2014 Jan;36(1):52-64
pubmed: 24323921
Lancet Oncol. 2021 May;22(5):678-689
pubmed: 33848462
Ann Oncol. 2016 Oct;27(10):1928-40
pubmed: 27672108
FEBS Lett. 2015 Apr 28;589(10):1049-58
pubmed: 25819438
J Biol Chem. 2002 Feb 8;277(6):4526-31
pubmed: 11733541
Hum Mol Genet. 2000 Sep 22;9(15):2223-9
pubmed: 11001925
Biochimie. 2013 Oct;95(10):1811-27
pubmed: 23764390
Biochim Biophys Acta. 1999 Mar 25;1437(3):341-56
pubmed: 10101268
Mol Neurobiol. 2013 Feb;47(1):361-72
pubmed: 23054682
Semin Cancer Biol. 2019 Dec;59:147-160
pubmed: 31128298
Genet Med. 2009 Oct;11(10):687-94
pubmed: 19668082
PLoS One. 2016 Mar 28;11(3):e0152611
pubmed: 27018598
Sci Transl Med. 2019 Mar 20;11(484):
pubmed: 30894500
J Virol. 2015 Nov 04;90(3):1158-68
pubmed: 26537687
Cancer Res. 2014 Jun 1;74(11):3054-66
pubmed: 24706697
J Clin Invest. 2014 Mar;124(3):1350-63
pubmed: 24569376
Rev Endocr Metab Disord. 2016 Dec;17(4):471-484
pubmed: 27315814
Am J Pathol. 2014 Jun;184(6):1630-42
pubmed: 24726643
iScience. 2019 Jan 25;11:160-177
pubmed: 30612035
J Biol Chem. 2005 Sep 23;280(38):33076-82
pubmed: 16049009
Acta Neuropathol Commun. 2020 Oct 19;8(1):167
pubmed: 33076971
Cell Cycle. 2019 Oct;18(20):2800-2813
pubmed: 31478454
Traffic. 2018 May;19(5):301-318
pubmed: 29411923
Mol Biol Rep. 2012 Jul;39(7):7389-402
pubmed: 22311048
Cell Biol Int. 2008 Jun;32(6):591-604
pubmed: 18304842
JCI Insight. 2023 May 8;8(9):
pubmed: 36943412
Cell Commun Signal. 2021 Feb 24;19(1):28
pubmed: 33627135
Am J Pathol. 2005 Oct;167(4):1081-92
pubmed: 16192643
J Proteome Res. 2017 Aug 4;16(8):2789-2801
pubmed: 28675297
Curr Genomics. 2007 Aug;8(5):271-306
pubmed: 19384426
Mol Biochem Parasitol. 1994 Feb;63(2):179-92
pubmed: 8008017
J Cell Sci. 2010 Sep 15;123(Pt 18):3071-83
pubmed: 20736309
Neuropathol Appl Neurobiol. 2014 Jun;40(4):489-501
pubmed: 23631697
Hum Mol Genet. 2015 Jul 1;24(13):3732-41
pubmed: 25855803
Neurobiol Aging. 2012 Jul;33(7):1487.e21-8
pubmed: 22137330
Biochim Biophys Acta. 2007 Mar;1771(3):353-404
pubmed: 17382260
Life Sci. 2020 Dec 1;262:118513
pubmed: 33011222
J Immunol. 2017 Sep 15;199(6):2096-2105
pubmed: 28779020
Pharmacogenomics. 2006 Apr;7(3):375-86
pubmed: 16610948
Oncotarget. 2019 Apr 12;10(28):2722-2737
pubmed: 31105872
Orphanet J Rare Dis. 2008 Sep 25;3:26
pubmed: 18817572
Exp Cell Res. 2001 May 1;265(2):329-38
pubmed: 11302699
Exp Cell Res. 2010 Dec 10;316(20):3368-78
pubmed: 20643123
Nat Commun. 2023 Aug 2;14(1):4652
pubmed: 37532690
Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E978-87
pubmed: 24591580
Explor Neuroprotective Ther. 2021;1:86-100
pubmed: 35098253
Mol Cell Biol. 2005 May;25(9):3630-8
pubmed: 15831468
Hum Mol Genet. 2013 Apr 15;22(8):1525-38
pubmed: 23307925
Biochim Biophys Acta. 2005 Jul 10;1744(3):396-405
pubmed: 15979509
Nat Cell Biol. 2015 Sep;17(9):1169-81
pubmed: 26280536
Brief Bioinform. 2011 Sep;12(5):449-62
pubmed: 21873635
Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8910-5
pubmed: 10900271
Plant Cell. 2005 May;17(5):1449-66
pubmed: 15805481
J Cell Biol. 2012 Dec 10;199(6):1003-16
pubmed: 23229899