Lupus Anticoagulant Detection under the Magnifying Glass.
activated partial thromboplastin time
anticoagulation
antiphospholipid antibody syndrome
lupus anticoagulant
thrombosis
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
20 Oct 2023
20 Oct 2023
Historique:
received:
06
09
2023
revised:
10
10
2023
accepted:
11
10
2023
medline:
28
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
Diagnosis of antiphospholipid syndrome (APS) requires the presence of a clinical criterion (thrombosis and/or pregnancy morbidity), combined with persistently circulating antiphospholipid antibodies (aPL). Lupus anticoagulant (LA) is one of the three laboratory parameters (the others being antibodies to either cardiolipin or β2-glycoprotein I) that defines this rare but potentially devastating condition. For the search for aCL and aβ2-GP-I, traditionally measured with immunological solid-phase assays (ELISA), several different assays and detection techniques are currently available, thus making these tests relatively reliable and widespread. On the other hand, LA detection is based on functional coagulation procedures that are characterized by poor standardization, difficulties in interpreting the results, and interference by several drugs commonly used in the clinical settings in which LA search is appropriate. This article aims to review the current state of the art and the challenges that clinicians and laboratories incur in the detection of LA.
Identifiants
pubmed: 37892792
pii: jcm12206654
doi: 10.3390/jcm12206654
pmc: PMC10607820
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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