Relocating Glyceryl Trinitrate as an Anti-Virulence Agent against
Pseudomonas aeruginosa
Serratia marcescens
bacterial virulence inhibition
glyceryl trinitrate
quorum sensing
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
28 Sep 2023
28 Sep 2023
Historique:
received:
05
09
2023
revised:
23
09
2023
accepted:
24
09
2023
medline:
28
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
The problem of antibiotic resistance is a global critical public health concern. In light of the threat of returning to the pre-antibiotic era, new alternative approaches are required such as quorum-sensing (QS) disruption and virulence inhibition, both of which apply no discernible selective pressure on bacteria, therefore mitigating the potential for the development of resistant strains. Bearing in mind the significant role of QS in orchestrating bacterial virulence, disrupting QS becomes essential for effectively diminishing bacterial virulence. This study aimed to assess the potential use of sub-inhibitory concentration (0.25 mg/mL) of glyceryl trinitrate (GTN) to inhibit virulence in
Identifiants
pubmed: 37894078
pii: microorganisms11102420
doi: 10.3390/microorganisms11102420
pmc: PMC10609227
pii:
doi:
Types de publication
Journal Article
Langues
eng
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