Unveiling Rare Pathogens and Antibiotic Resistance in Tanzanian Cholera Outbreak Waters.
ESBL
One Health
antibiotic resistance
bacteriophage
cholera
microbiota
transduction
water
zoonotic pathogen
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
04 Oct 2023
04 Oct 2023
Historique:
received:
01
09
2023
revised:
27
09
2023
accepted:
28
09
2023
medline:
28
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
The emergence of antibiotic resistance is a global health concern. Therefore, understanding the mechanisms of its spread is crucial for implementing evidence-based strategies to tackle resistance in the context of the One Health approach. In developing countries where sanitation systems and access to clean and safe water are still major challenges, contamination may introduce bacteria and bacteriophages harboring antibiotic resistance genes (ARGs) into the environment. This contamination can increase the risk of exposure and community transmission of ARGs and infectious pathogens. However, there is a paucity of information on the mechanisms of bacteriophage-mediated spread of ARGs and patterns through the environment. Here, we deploy Droplet Digital PCR (ddPCR) and metagenomics approaches to analyze the abundance of ARGs and bacterial pathogens disseminated through clean and wastewater systems. We detected a relatively less-studied and rare human zoonotic pathogen,
Identifiants
pubmed: 37894148
pii: microorganisms11102490
doi: 10.3390/microorganisms11102490
pmc: PMC10609457
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Swedish Research Council Formas
ID : 2017-00100
Organisme : Innovation Fund Denmark
ID : 7044-00005B
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