Mucin Glycans: A Target for Cancer Therapy.
MUC1
cancer
glycosylation
mucin
targeted therapy
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
11 Oct 2023
11 Oct 2023
Historique:
received:
13
09
2023
revised:
08
10
2023
accepted:
10
10
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
Mucin glycans are an important component of the mucus barrier and a vital defence against physical and chemical damage as well as pathogens. There are 20 mucins in the human body, which can be classified into secreted mucins and transmembrane mucins according to their distributions. The major difference between them is that secreted mucins do not have transmembrane structural domains, and the expression of each mucin is organ and cell-specific. Under physiological conditions, mucin glycans are involved in the composition of the mucus barrier and thus protect the body from infection and injury. However, abnormal expression of mucin glycans can lead to the occurrence of diseases, especially cancer, through various mechanisms. Therefore, targeting mucin glycans for the diagnosis and treatment of cancer has always been a promising research direction. Here, we first summarize the main types of glycosylation (O-GalNAc glycosylation and N-glycosylation) on mucins and the mechanisms by which abnormal mucin glycans occur. Next, how abnormal mucin glycans contribute to cancer development is described. Finally, we summarize MUC1-based antibodies, vaccines, radio-pharmaceuticals, and CAR-T therapies using the best characterized MUC1 as an example. In this section, we specifically elaborate on the recent new cancer therapy CAR-M, which may bring new hope to cancer patients.
Identifiants
pubmed: 37894512
pii: molecules28207033
doi: 10.3390/molecules28207033
pmc: PMC10609567
pii:
doi:
Substances chimiques
Mucins
0
Mucin-1
0
Polysaccharides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 22264023, 82060521, 82260489, and 82260530
Organisme : Health Research Project of Shaanxi Province
ID : 2022E019
Organisme : Scientific Research Projects of Education Department of Shaanxi Provincial Government
ID : 22JK0614
Organisme : Ph.D. start-up fund of Yan'an University
ID : YDBK2020-30, YDBK2022-15
Organisme : Shaanxi Province Key Science and Technology innovation team
ID : 2020TD-039
Organisme : Innovation Team of Yan'an City-Innovation Team for Chronic Disease Prevention and Control
ID : 2018CXTD-03
Références
Glycobiology. 2006 Jul;16(7):623-34
pubmed: 16585136
Mol Cancer. 2006 Oct 26;5(1):50
pubmed: 17067392
mBio. 2022 Apr 26;13(2):e0003922
pubmed: 35323039
Biomolecules. 2021 Sep 06;11(9):
pubmed: 34572532
Front Chem. 2019 Oct 22;7:710
pubmed: 31696111
Int J Gynecol Cancer. 2010 Jan;20(1):16-22
pubmed: 20130498
Clin Cancer Res. 1998 Feb;4(2):295-302
pubmed: 9516914
Adv Drug Deliv Rev. 2009 Feb 27;61(2):75-85
pubmed: 19135107
Nat Rev Mol Cell Biol. 2020 Dec;21(12):729-749
pubmed: 33087899
Chem Biol. 1997 Feb;4(2):97-104
pubmed: 9190292
Matrix Biol. 2023 Apr;118:47-68
pubmed: 36882122
Sci Rep. 2017 Jan 20;7:40656
pubmed: 28106125
Curr Med Chem. 2010;17(24):2656-83
pubmed: 20491630
Biochem J. 2005 Nov 1;391(Pt 3):491-502
pubmed: 15926890
Biochim Biophys Acta Rev Cancer. 2021 Aug;1876(1):188538
pubmed: 33862149
Nat Rev Microbiol. 2006 Mar;4(3):229-36
pubmed: 16489349
Oncol Lett. 2022 Mar;23(3):97
pubmed: 35154428
Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):225-32
pubmed: 11773621
J Cell Biochem. 2019 Apr;120(4):5010-5017
pubmed: 30260046
Cancer Res. 2010 Feb 15;70(4):1306-13
pubmed: 20124478
J Exp Clin Cancer Res. 2017 Sep 4;36(1):117
pubmed: 28870205
Biochem J. 2015 Jul 1;469(1):83-95
pubmed: 25916169
Int J Mol Sci. 2020 Aug 20;21(17):
pubmed: 32825245
Cancers (Basel). 2021 May 25;13(11):
pubmed: 34070311
Cancer Metastasis Rev. 2019 Jun;38(1-2):223-236
pubmed: 30618016
Cancer Lett. 1998 Sep 25;131(2):129-36
pubmed: 9851244
Front Immunol. 2022 Oct 25;13:1009621
pubmed: 36389707
J Cell Sci. 2013 Sep 1;126(Pt 17):3799-804
pubmed: 23970415
Curr Opin Struct Biol. 2019 Jun;56:64-71
pubmed: 30665188
Nat Rev Immunol. 2009 May;9(5):338-52
pubmed: 19365409
IUBMB Life. 2017 Nov;69(11):824-833
pubmed: 28940845
Glycobiology. 2015 Dec;25(12):1323-4
pubmed: 26543186
Transl Oncol. 2018 Jun;11(3):786-793
pubmed: 29702465
J Biol Chem. 1990 Sep 5;265(25):15286-93
pubmed: 1697589
Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17059-64
pubmed: 24062455
J Virol. 2007 Feb;81(4):1554-62
pubmed: 17151127
Glycobiology. 2018 Sep 1;28(9):648-655
pubmed: 29272415
Glycobiology. 2012 Aug;22(8):1042-54
pubmed: 22534569
EMBO Rep. 2006 Jun;7(6):599-604
pubmed: 16741504
Ther Adv Med Oncol. 2017 Mar;9(3):147-157
pubmed: 28344660
J Biol Chem. 1998 Jul 24;273(30):18857-63
pubmed: 9668061
Acta Histochem. 2011 Oct;113(6):591-600
pubmed: 21501858
Biochem Biophys Res Commun. 2022 Nov 12;629:121-127
pubmed: 36116374
Biochimie. 2010 Jan;92(1):1-11
pubmed: 19818375
Transl Res. 2016 Mar;169:19-30.e1
pubmed: 26589109
Cancer Biol Ther. 2007 Apr;6(4):481-6
pubmed: 18027437
Adv Exp Med Biol. 2018;1066:59-78
pubmed: 30030822
Nat Immunol. 2016 Nov;17(11):1273-1281
pubmed: 27595232
Int J Cancer. 1998 Apr 17;79(2):133-8
pubmed: 9583726
Prog Lipid Res. 2023 Jul;91:101241
pubmed: 37524133
Theranostics. 2018 Jan 1;8(1):78-91
pubmed: 29290794
Int J Clin Exp Pathol. 2013;6(4):613-21
pubmed: 23573307
Nat Struct Mol Biol. 2019 Jun;26(6):415-423
pubmed: 31133698
Inflamm Bowel Dis. 2011 Nov;17(11):2299-307
pubmed: 21290483
Cell Signal. 2009 May;21(5):665-74
pubmed: 19167485
Nucl Med Biol. 2022 May-Jun;108-109:33-43
pubmed: 35276446
Invest Ophthalmol Vis Sci. 1983 May;24(5):570-6
pubmed: 6841003
Clin Cancer Res. 2012 Mar 1;18(5):1364-73
pubmed: 22261809
Int J Biol Macromol. 2021 Aug 31;185:664-678
pubmed: 34224755
Semin Immunol. 2020 Feb;47:101389
pubmed: 31926647
Cancers (Basel). 2023 Jun 21;15(13):
pubmed: 37444377
Int J Oncol. 1998 May;12(5):1157-64
pubmed: 9538143
Mol Pharm. 2021 May 3;18(5):1842-1861
pubmed: 33821638
Sci Rep. 2016 May 10;6:25575
pubmed: 27161092
Clin Cancer Res. 2004 Feb 1;10(3):803-21
pubmed: 14871955
Annu Rev Biochem. 1985;54:631-64
pubmed: 3896128
Nat Rev Cancer. 2004 Jul;4(7):528-39
pubmed: 15229478
Cancer Metastasis Rev. 1992 Nov;11(3-4):353-75
pubmed: 1423822
Cancer Med. 2020 Jan;9(2):640-652
pubmed: 31800160
Nat Rev Drug Discov. 2020 Sep;19(9):589-608
pubmed: 32728208
PLoS Pathog. 2012 Feb;8(2):e1002501
pubmed: 22319443
Clin Cancer Res. 2009 Sep 1;15(17):5323-37
pubmed: 19723653
Science. 1984 Jun 15;224(4654):1198-206
pubmed: 6729450
Sci Transl Med. 2019 Sep 11;11(509):
pubmed: 31511426
Cancer Res. 1987 Oct 15;47(20):5476-82
pubmed: 2443241
Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 May;49(3):358-363
pubmed: 30014634
Glycoconj J. 2015 Nov;32(8):575-613
pubmed: 26239922
Virol J. 2011 May 08;8:208
pubmed: 21548981
J Cell Physiol. 2009 Jul;220(1):144-54
pubmed: 19277980
Biochim Biophys Acta. 1999 Dec 6;1473(1):67-95
pubmed: 10580130
Nat Rev Cancer. 2004 Jan;4(1):45-60
pubmed: 14681689
Lancet Respir Med. 2021 Nov;9(11):1241-1254
pubmed: 34058148
Glycoconj J. 2021 Aug;38(4):459-474
pubmed: 33704667
Lancet Oncol. 2016 Feb;17(2):212-223
pubmed: 26727163
J Pathol. 2014 Sep;234(1):60-73
pubmed: 24838315
Comput Struct Biotechnol J. 2014 Jun 11;10(16):23-32
pubmed: 25210595
Nat Biotechnol. 2020 Aug;38(8):947-953
pubmed: 32361713
Urology. 2013 Jan;81(1):210.e11-5
pubmed: 23102779
J Biol Chem. 2009 Aug 21;284(34):23037-45
pubmed: 19556244
Cancer Cell. 2019 Jul 8;36(1):6-16
pubmed: 31287993
Biochem J. 2003 Aug 1;373(Pt 3):893-900
pubmed: 12744721
Curr Opin Struct Biol. 2019 Jun;56:171-178
pubmed: 30999272
J Mammary Gland Biol Neoplasia. 2001 Jul;6(3):339-53
pubmed: 11547902
Oncotarget. 2014 Apr 15;5(7):1885-96
pubmed: 24681892
Cancer Res. 2008 May 15;68(10):3803-9
pubmed: 18483264
Ann Surg. 2011 Nov;254(5):684-93; discussion 693
pubmed: 22005144
J Cell Sci. 2003 Apr 1;116(Pt 7):1305-18
pubmed: 12615972
Histopathology. 2019 Mar;74(4):597-607
pubmed: 30565710
Nano Converg. 2020 Dec 10;7(1):38
pubmed: 33301056
Nat Commun. 2017 Dec 19;8(1):2196
pubmed: 29259165
Annu Rev Physiol. 1995;57:547-64
pubmed: 7778877
Clin Cancer Res. 2017 Mar 15;23(6):1373-1378
pubmed: 28039261
Front Oncol. 2018 Feb 23;8:39
pubmed: 29527514
Cancer Res. 2009 Sep 1;69(17):6799-806
pubmed: 19690136
World J Gastroenterol. 2001 Apr;7(2):203-7
pubmed: 11819761
Immunology. 1999 Oct;98(2):213-9
pubmed: 10610356
Molecules. 2018 Nov 23;23(12):
pubmed: 30477085
J Biol Chem. 2008 Jun 20;283(25):17298-313
pubmed: 18411279
Oncol Rep. 2015 Feb;33(2):826-32
pubmed: 25434827
Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16613-8
pubmed: 12464682
J Exp Med. 2020 Jan 6;217(1):
pubmed: 31645367
Biochim Biophys Acta. 2008 Mar;1780(3):546-63
pubmed: 17988798
Cancer Biol Ther. 2020 Jun 2;21(6):570-580
pubmed: 32208880
Immunity. 2016 Jun 21;44(6):1444-54
pubmed: 27332733
Cancer Immunol Immunother. 2010 Dec;59(12):1801-11
pubmed: 20824430
Cancer Manag Res. 2020 Oct 08;12:9813-9824
pubmed: 33116840
Nat Rev Gastroenterol Hepatol. 2013 Jun;10(6):352-61
pubmed: 23478383
Cancer Cell Int. 2022 Dec 27;22(1):417
pubmed: 36572921
Adv Drug Deliv Rev. 2022 May;184:114182
pubmed: 35278522
Folia Histochem Cytobiol. 2012 Oct 08;50(3):398-406
pubmed: 23042270
Int J Biol Sci. 2019 Jan 1;15(1):169-182
pubmed: 30662357
Tumour Biol. 2011 Feb;32(1):203-13
pubmed: 20872286
Oncogene. 2023 Mar;42(12):926-937
pubmed: 36725887
Nucl Med Biol. 2008 Oct;35(7):763-8
pubmed: 18848661
Biochem J. 2013 Aug 1;453(3):427-34
pubmed: 23718681
Virology. 2020 Feb;541:63-74
pubmed: 32056716
Front Biosci. 2001 Oct 01;6:D1216-34
pubmed: 11578973
Glycobiology. 2006 Feb;16(2):96-107
pubmed: 16207894
BMC Cancer. 2009 Jun 18;9:191
pubmed: 19534821
Biochim Biophys Acta. 2015 Dec;1856(2):211-25
pubmed: 26318196
Oncotarget. 2015 Mar 20;6(8):6123-35
pubmed: 25762620
Theranostics. 2023 Jan 1;13(2):767-786
pubmed: 36632233
PLoS One. 2013 Sep 06;8(9):e72413
pubmed: 24039759
Nat Rev Nephrol. 2019 Jun;15(6):346-366
pubmed: 30858582
J Exp Clin Cancer Res. 2022 Mar 31;41(1):119
pubmed: 35361234
Glycobiology. 2013 Sep;23(9):1026-37
pubmed: 23752712
Transl Res. 2023 Mar;253:41-56
pubmed: 36031050
Glycobiology. 2012 Dec;22(12):1731-40
pubmed: 22833315
Int J Oncol. 2004 Oct;25(4):937-43
pubmed: 15375543
J Cell Sci. 1993 Jul;105 ( Pt 3):819-30
pubmed: 7691849
Front Immunol. 2019 May 24;10:1149
pubmed: 31178870
Adv Drug Deliv Rev. 2022 Dec;191:114540
pubmed: 36228896
Cancer Res. 2010 Apr 1;70(7):2759-69
pubmed: 20215525
Oncol Rep. 1999 Mar-Apr;6(2):341-4
pubmed: 10023001
Glycobiology. 2001 Aug;11(8):633-44
pubmed: 11479274
Front Cell Dev Biol. 2020 Aug 26;8:749
pubmed: 32984308
EBioMedicine. 2022 Feb;76:103873
pubmed: 35152151
J Biol Chem. 2017 Jun 30;292(26):11079-11090
pubmed: 28487369
Med Res Rev. 2017 Nov;37(6):1518-1539
pubmed: 28759115
BMB Rep. 2021 Jul;54(7):344-355
pubmed: 34154702
Cancer Res. 2008 Mar 15;68(6):1636-46
pubmed: 18339842
Br J Cancer. 2000 Nov;83(9):1202-8
pubmed: 11027434
Nat Microbiol. 2021 May;6(5):574-583
pubmed: 33737747
Glycoconj J. 1997 Jan;14(1):107-11
pubmed: 9076520
Cancer. 1952 Jul;5(4):700-7
pubmed: 14935980
Nat Rev Cancer. 2015 Sep;15(9):540-55
pubmed: 26289314
Sci Transl Med. 2019 Jun 19;11(497):
pubmed: 31217340
Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2894-8
pubmed: 26800384
Cancer Res. 2004 Mar 1;64(5):1821-7
pubmed: 14996745
Cancer Treat Rev. 2008 Feb;34(1):13-26
pubmed: 17870245
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10231-3
pubmed: 12149519
Oncogene. 2017 Feb 2;36(5):700-713
pubmed: 27399336
Oncotarget. 2017 Nov 3;9(1):1380-1402
pubmed: 29416702
Trends Cell Biol. 1998 Jan;8(1):34-40
pubmed: 9695806
J Leukoc Biol. 2014 Aug;96(2):201-12
pubmed: 24868089
Cells. 2020 Apr 20;9(4):
pubmed: 32326128
Gastroenterology. 1998 Mar;114(3):462-70
pubmed: 9496936
EJNMMI Radiopharm Chem. 2021 Mar 18;6(1):12
pubmed: 33738611
Lancet Glob Health. 2020 Feb;8(2):e180-e190
pubmed: 31862245
Crit Rev Biochem Mol Biol. 1998;33(3):151-208
pubmed: 9673446
Br J Cancer. 2009 Jun 2;100(11):1746-54
pubmed: 19436292
J Cancer Res Clin Oncol. 2003 Dec;129(12):683-90
pubmed: 14576935
Talanta. 2018 Mar 1;179:356-363
pubmed: 29310244
Anticancer Res. 2017 Nov;37(11):6031-6039
pubmed: 29061782
Curr Opin Struct Biol. 2019 Jun;56:78-86
pubmed: 30690220
Chem Commun (Camb). 2020 Dec 8;56(96):15137-15140
pubmed: 33211039
Front Genet. 2015 Mar 19;6:81
pubmed: 25852737
Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):261-6
pubmed: 22171012
Cell Death Discov. 2017 Jul 17;3:17044
pubmed: 28725490
Cancer Biomark. 2014 Jan 1;14(1):63-81
pubmed: 24643043
Cancer Discov. 2013 Apr;3(4):388-98
pubmed: 23550147
Mol Biosyst. 2009 Oct;5(10):1087-104
pubmed: 19756298
J Immunother. 2023 Apr 1;46(3):89-95
pubmed: 36883998
J Mammary Gland Biol Neoplasia. 2001 Jul;6(3):355-64
pubmed: 11547903
Cancer Immunol Res. 2017 Dec;5(12):1152-1161
pubmed: 29109077
J Biol Chem. 1997 Sep 26;272(39):24198-202
pubmed: 9305871
Glycobiology. 2001 May;11(5):385-93
pubmed: 11425799
Cancer Lett. 2021 Apr 10;503:91-102
pubmed: 33485947
Prostate. 2014 Jul;74(10):1059-67
pubmed: 24854630
J Biol Chem. 1997 Sep 5;272(36):22695-702
pubmed: 9278427
Glycoconj J. 2001 Nov-Dec;18(11-12):925-30
pubmed: 12820726
Int J Cancer. 1981 Jul 15;28(1):17-21
pubmed: 7309278
Mol Cancer Ther. 2021 Oct;20(10):1977-1987
pubmed: 34376583
J Cell Physiol. 2006 Jul;208(1):167-74
pubmed: 16547942
Annu Rev Biochem. 2020 Jun 20;89:769-793
pubmed: 32243763
Int J Nanomedicine. 2016 Dec 19;12:53-60
pubmed: 28053523
Recent Results Cancer Res. 1996;140:101-13
pubmed: 8787054
Biomed Pharmacother. 2020 Dec;132:110888
pubmed: 33113416
Nat Rev Cancer. 2005 Jul;5(7):526-42
pubmed: 16069816
Cells. 2020 Feb 14;9(2):
pubmed: 32075174
Annu Rev Cell Dev Biol. 2006;22:375-407
pubmed: 16805665
Theranostics. 2018 Jul 30;8(16):4305-4320
pubmed: 30214622
Redox Biol. 2022 Aug;54:102366
pubmed: 35728303
Breast Cancer Res Treat. 2019 Jan;173(2):289-299
pubmed: 30317423
Int J Cancer. 1989 Oct 15;44(4):691-6
pubmed: 2477336
Glycobiology. 2017 Jan;27(1):3-49
pubmed: 27558841
Mol Cancer. 2019 Jan 15;18(1):10
pubmed: 30646912
Int J Cancer. 2022 Aug 15;151(4):565-577
pubmed: 35484982