Anti-Neurodegenerating Activity: Structure-Activity Relationship Analysis of Flavonoids.
SAR
computational
flavones
flavonoids
in silico
neurodegeneration
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
20 Oct 2023
20 Oct 2023
Historique:
received:
29
09
2023
revised:
16
10
2023
accepted:
17
10
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
An anti-neurodegeneration activity study was carried out for 80 flavonoid compounds. The structure-activity analysis of the structures was carried out by performing three different anti-neurodegeneration screening tests, showing that in these structures, the presence of a hydroxy substituent group at position C3' as well as C5' of ring B and a methoxy substituent group at the C7 position of ring A play a vital role in neuroprotective and antioxidant as well as anti-inflammatory activity. Further, we found structure (
Identifiants
pubmed: 37894669
pii: molecules28207188
doi: 10.3390/molecules28207188
pmc: PMC10609304
pii:
doi:
Substances chimiques
Flavonoids
0
Antioxidants
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Biomedicines. 2021 Jan 20;9(2):
pubmed: 33498503
Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2687-92
pubmed: 20133810
J Neurosci. 1998 Oct 1;18(19):8047-55
pubmed: 9742171
Molecules. 2020 Nov 11;25(22):
pubmed: 33187049
Bioorg Med Chem Lett. 2003 Nov 17;13(22):3905-8
pubmed: 14592472
Pharmaceutics. 2023 May 28;15(6):
pubmed: 37376054
Science. 1997 Jan 3;275(5296):90-4
pubmed: 8974401
J Agric Food Chem. 2005 Nov 2;53(22):8537-41
pubmed: 16248550
J Agric Food Chem. 2010 Feb 24;58(4):2111-5
pubmed: 20095615
Neurotherapeutics. 2015 Jan;12(1):49-56
pubmed: 25371167
Int J Mol Sci. 2013 Apr 10;14(4):7771-83
pubmed: 23574938
Nature. 2016 Nov 09;539(7628):207-216
pubmed: 27830778
Inflamm Allergy Drug Targets. 2010 Sep;9(4):263-85
pubmed: 20887269
Nutrients. 2018 May 19;10(5):
pubmed: 29783725
Neurobiol Aging. 2007 Apr;28(4):533-6
pubmed: 16569464
Oxid Med Cell Longev. 2020 Mar 27;2020:5497046
pubmed: 32308803
Neurosci Lett. 2009 Sep 18;461(2):172-6
pubmed: 19539722
Carcinogenesis. 1998 Oct;19(10):1771-6
pubmed: 9806157
J Chem Inf Model. 2005 Jan-Feb;45(1):160-9
pubmed: 15667141
Eur J Med Chem. 2018 May 25;152:570-589
pubmed: 29763806
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Antioxid Redox Signal. 2009 Oct;11(10):2481-504
pubmed: 19309263
Ther Adv Psychopharmacol. 2018 Jan;8(1):33-48
pubmed: 29344342
Behav Brain Res. 2011 Feb 2;217(1):10-5
pubmed: 20888863
Biochem Pharmacol. 2013 Dec 15;86(12):1739-46
pubmed: 24134915
Mol Cell Neurosci. 2009 Feb;40(2):217-24
pubmed: 19038345
EMBO Mol Med. 2015 Jan 23;7(2):190-210
pubmed: 25617315
Nature. 2016 Nov 09;539(7628):187-196
pubmed: 27830780
Food Chem. 2022 Jul 30;383:132531
pubmed: 35413752
ScientificWorldJournal. 2013 Dec 29;2013:162750
pubmed: 24470791
Science. 2002 Jul 19;297(5580):353-6
pubmed: 12130773
Biochem J. 2013 Aug 1;453(3):393-9
pubmed: 23679855
Molecules. 2019 Apr 22;24(8):
pubmed: 31013638
Free Radic Biol Med. 2001 Feb 15;30(4):433-46
pubmed: 11182299
Pharmaceutics. 2023 Aug 26;15(9):
pubmed: 37765179
Food Chem. 2012 Sep 15;134(2):717-24
pubmed: 23107683
Oxid Med Cell Longev. 2018 May 10;2018:7043213
pubmed: 29861833
Drug Discov Today Technol. 2010 Winter;7(4):e203-70
pubmed: 24103798
Mol Neurodegener. 2017 May 25;12(1):42
pubmed: 28545479
J Clin Invest. 2003 Jan;111(1):3-10
pubmed: 12511579
Biochem Biophys Res Commun. 2000 Jun 24;273(1):5-9
pubmed: 10873554
Sci Rep. 2017 Mar 03;7:42717
pubmed: 28256516
Antioxidants (Basel). 2020 Oct 23;9(11):
pubmed: 33114058
Expert Opin Investig Drugs. 2003 Jul;12(7):1143-51
pubmed: 12831349
Molecules. 2007 Sep 03;12(9):2130-9
pubmed: 17962731
Biomed Rep. 2016 May;4(5):519-522
pubmed: 27123241
Neurosci Lett. 1992 Nov 23;147(1):58-62
pubmed: 1336152
J Comput Chem. 2010 Jan 30;31(2):455-61
pubmed: 19499576
Trends Pharmacol Sci. 2012 Nov;33(11):602-10
pubmed: 22980637
Asian J Pharm Sci. 2018 Jan;13(1):12-23
pubmed: 32104374
Pharmaceuticals (Basel). 2021 Jan 05;14(1):
pubmed: 33466332
J Cent Nerv Syst Dis. 2017 May 15;9:1179573517709278
pubmed: 28579870
J Med Chem. 2005 Nov 17;48(23):7253-60
pubmed: 16279784
Chem Biol Interact. 2012 May 30;197(2-3):103-9
pubmed: 22542668
Biochem J. 2003 May 15;372(Pt 1):173-81
pubmed: 12578560
J Biol Chem. 2003 Sep 12;278(37):34783-93
pubmed: 12826665
Int J Nanomedicine. 2019 Jul 19;14:5541-5554
pubmed: 31410002
J Biol Chem. 2001 Feb 16;276(7):5287-95
pubmed: 11083861
Biosci Biotechnol Biochem. 2010;74(2):397-401
pubmed: 20139605
Nat Rev Neurosci. 2001 Apr;2(4):294-302
pubmed: 11283752
Structure. 2001 Dec;9(12):1191-9
pubmed: 11738045
Neuropharmacology. 2010 Nov;59(6):542-50
pubmed: 20708632
ASN Neuro. 2011 Feb 08;3(1):e00050
pubmed: 21434871
J Chem Inf Model. 2015 Feb 23;55(2):460-73
pubmed: 25558886
Biochemistry. 2001 Sep 4;40(35):10447-57
pubmed: 11523986
Food Chem Toxicol. 2009 Mar;47(3):625-32
pubmed: 19146912
Cell Signal. 2014 Mar;26(3):657-63
pubmed: 24361374
Nature. 2016 Nov 10;539(7628):197-206
pubmed: 27830784
Neuron. 2002 Aug 15;35(4):711-9
pubmed: 12194870
Nature. 2016 Nov 09;539(7628):180-186
pubmed: 27830812
J Agric Food Chem. 2007 Mar 21;55(6):2438-45
pubmed: 17323972
J Chem Inf Model. 2011 Oct 24;51(10):2778-86
pubmed: 21919503
CNS Neurol Disord Drug Targets. 2018 Apr 26;17(1):34-42
pubmed: 29268692
J Agric Food Chem. 2000 Aug;48(8):3217-24
pubmed: 10956094
J Neurosci. 1999 Sep 15;19(18):8114-21
pubmed: 10479711
Nat Neurosci. 2018 Oct;21(10):1293
pubmed: 30258240
Cells. 2020 May 19;9(5):
pubmed: 32438615
J Cell Mol Med. 2009 Mar;13(3):574-88
pubmed: 18410522
J Am Osteopath Assoc. 2010 Sep;110(9 Suppl 8):S16-26
pubmed: 20926739
Free Radic Biol Med. 2001 Nov 1;31(9):1139-46
pubmed: 11677047
Antioxid Redox Signal. 2010 Jun 15;12(12):1371-82
pubmed: 19929442
Phytother Res. 2021 Apr;35(4):1719-1738
pubmed: 33058407
Biochem Soc Trans. 2019 Oct 31;47(5):1557-1565
pubmed: 31642904
Biomol Ther (Seoul). 2019 Mar 1;27(2):145-151
pubmed: 30514054