IRAK3 Knockout and Wildtype THP-1 Monocytes as Models for Endotoxin Detection Assays and
THP-1 monocytes
antimicrobial resistance
bacteriophage therapy
bacteriophages
endotoxin
interleukin-1 receptor associated kinase-3 (IRAK-3)
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Oct 2023
12 Oct 2023
Historique:
received:
25
08
2023
revised:
03
10
2023
accepted:
09
10
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
Microbial resistance to antibiotics poses a tremendous challenge. Bacteriophages may provide a useful alternative or adjunct to traditional antibiotics. To be used in therapy, bacteriophages need to be purified from endotoxins and tested for their effects on human immune cells. Interleukin-1 Receptor Associated Kinase-3 (IRAK3) is a negative regulator of inflammation and may play a role in the modulation of immune signalling upon bacteriophage exposure to immune cells. This study aimed to investigate the immune effects of crude and purified bacteriophage FNU1, a bacteriophage that targets the oral pathobiont
Identifiants
pubmed: 37894788
pii: ijms242015108
doi: 10.3390/ijms242015108
pmc: PMC10606876
pii:
doi:
Substances chimiques
Cytokines
0
Endotoxins
0
Tumor Necrosis Factor-alpha
0
Anti-Bacterial Agents
0
IRAK3 protein, human
EC 2.7.11.1
Interleukin-1 Receptor-Associated Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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