Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity.
anticancer activity
blackberry
ellagic acid
extraction
purification
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Oct 2023
16 Oct 2023
Historique:
received:
28
09
2023
revised:
11
10
2023
accepted:
12
10
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
Ellagic acid (EA) is present at relatively high concentrations in many berries and has many beneficial health effects, including anticancer properties. To improve the development and utilization of blackberry fruit nutrients, we divided Hull blackberry fruits into five growth periods according to color and determined the EA content in the fruits in each period. The EA content in the green fruit stage was the highest at 5.67 mg/g FW. Single-factor tests and response surface methodology were used to optimize the extraction process, while macroporous resin adsorption and alkali dissolution, acid precipitation, and solvent recrystallization were used for purification. The highest purity of the final EA powder was 90%. The anticancer assessment results determined by MTT assay showed that EA inhibited HeLa cells with an IC
Identifiants
pubmed: 37894909
pii: ijms242015228
doi: 10.3390/ijms242015228
pmc: PMC10607623
pii:
doi:
Substances chimiques
Ellagic Acid
19YRN3ZS9P
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Jiangsu Province Key Project of R&D Plan (Modern Agriculture)
ID : BE2020344
Organisme : Chinese Central Financial Project for Cooperative Extension of Major Agricultural Technology
ID : 2022-ZYXT-06
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