Melatonin and Its Metabolites Can Serve as Agonists on the Aryl Hydrocarbon Receptor and Peroxisome Proliferator-Activated Receptor Gamma.
AhR
PPARγ
melatonin
melatonin metabolites
modeling
receptors
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Oct 2023
23 Oct 2023
Historique:
received:
24
08
2023
revised:
17
10
2023
accepted:
18
10
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
Melatonin is widely present in Nature. It has pleiotropic activities, in part mediated by interactions with high-affinity G-protein-coupled melatonin type 1 and 2 (MT1 and MT2) receptors or under extreme conditions, e.g., ischemia/reperfusion. In pharmacological concentrations, it is given to counteract the massive damage caused by MT1- and MT2-independent mechanisms. The aryl hydrocarbon receptor (AhR) is a perfect candidate for mediating the latter effects because melatonin has structural similarity to its natural ligands, including tryptophan metabolites and indolic compounds. Using a cell-based Human AhR Reporter Assay System, we demonstrated that melatonin and its indolic and kynuric metabolites act as agonists on the AhR with EC
Identifiants
pubmed: 37895177
pii: ijms242015496
doi: 10.3390/ijms242015496
pmc: PMC10607054
pii:
doi:
Substances chimiques
Ligands
0
Melatonin
JL5DK93RCL
PPAR gamma
0
Receptors, Aryl Hydrocarbon
0
PPARG protein, human
0
AHR protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR071189
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR073004
Pays : United States
Organisme : VA
ID : 1I01BX004293-01A1
Pays : United States
Organisme : BLRD VA
ID : I01 BX004293
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI149267
Pays : United States
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