Usnic Acid Derivatives Inhibit DNA Repair Enzymes Tyrosyl-DNA Phosphodiesterases 1 and 2 and Act as Potential Anticancer Agents.
Tdp1 inhibitors
Tdp2 inhibitors
tyrosyl-DNA phosphodiesterase 1 (Tdp1)
tyrosyl-DNA phosphodiesterase 2 (Tdp2)
usnic acid
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
12 10 2023
12 10 2023
Historique:
received:
03
08
2023
revised:
04
09
2023
accepted:
27
09
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
Tyrosyl-DNA phosphodiesterase 1 and 2 (Tdp1 and Tdp2) are DNA repair enzymes that repair DNA damage caused by various agents, including anticancer drugs. Thus, these enzymes resist anticancer therapy and could be the reason for resistance to such widely used drugs such as topotecan and etoposide. In the present work, we found compounds capable of inhibiting both enzymes among derivatives of (-)-usnic acid. Both (+)- and (-)-enantiomers of compounds act equally effectively against Tdp1 with IC
Identifiants
pubmed: 37895279
pii: genes14101931
doi: 10.3390/genes14101931
pmc: PMC10606488
pii:
doi:
Substances chimiques
tyrosyl-DNA phosphodiesterase
EC 3.1.4.-
DNA-Binding Proteins
0
usnic acid
0W584PFJ77
Etoposide
6PLQ3CP4P3
Dimethyl Sulfoxide
YOW8V9698H
Phosphoric Diester Hydrolases
EC 3.1.4.-
Antineoplastic Agents
0
DNA Repair Enzymes
EC 6.5.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Planta Med. 2019 Jan;85(2):103-111
pubmed: 30142660
Int J Mol Sci. 2023 May 23;24(11):
pubmed: 37298106
EMBO J. 2009 Mar 18;28(6):632-40
pubmed: 19197239
Nucleic Acids Res. 2018 Jan 25;46(2):520-537
pubmed: 29216365
J Chem Theory Comput. 2019 Mar 12;15(3):1863-1874
pubmed: 30768902
DNA Repair (Amst). 2009 Jun 4;8(6):760-6
pubmed: 19303373
Molecules. 2022 Dec 31;28(1):
pubmed: 36615517
EMBO J. 2007 Nov 14;26(22):4720-31
pubmed: 17914460
DNA Repair (Amst). 2016 Jul;43:38-47
pubmed: 27235629
Cell Mol Life Sci. 2020 Jan;77(1):81-91
pubmed: 31728578
EMBO J. 2007 Nov 14;26(22):4732-43
pubmed: 17948061
Int J Mol Sci. 2019 Dec 23;21(1):
pubmed: 31878088
Int J Mol Sci. 2021 Oct 20;22(21):
pubmed: 34768766
Future Oncol. 2014 May;10(7):1215-37
pubmed: 24947262
Cancer Drug Resist. 2019;2:1153-1163
pubmed: 31875206
Eur J Med Chem. 2018 May 10;151:777-796
pubmed: 29677635
Chem Biol. 2010 May 28;17(5):421-33
pubmed: 20534341
Med Res Rev. 2019 Jul;39(4):1427-1441
pubmed: 31004352
Curr Med Chem. 2012;19(23):3874-85
pubmed: 22788763
Drug Metab Rev. 2014 Nov;46(4):494-507
pubmed: 25327705
Molecules. 2019 Oct 15;24(20):
pubmed: 31619021
ACS Chem Biol. 2016 Jul 15;11(7):1925-33
pubmed: 27128689
J Mol Biol. 2007 Sep 28;372(4):1070-1081
pubmed: 17707402
ACS Chem Biol. 2013 Jan 18;8(1):82-95
pubmed: 23259582
Clin Exp Metastasis. 2021 Oct;38(5):431-440
pubmed: 34370156
Nucleic Acids Res. 2000 Jan 1;28(1):235-42
pubmed: 10592235
Int J Mol Sci. 2023 Mar 17;24(6):
pubmed: 36982848
J Immunol Methods. 1983 Dec 16;65(1-2):55-63
pubmed: 6606682
J Biol Chem. 2004 Dec 31;279(53):55618-25
pubmed: 15494395
J Nat Prod. 2016 Nov 23;79(11):2961-2967
pubmed: 27933897
J Biol Chem. 2012 Apr 13;287(16):12848-57
pubmed: 22375014
Nature. 2009 Oct 1;461(7264):674-8
pubmed: 19794497
Nat Rev Cancer. 2009 May;9(5):338-50
pubmed: 19377506
J Med Chem. 2017 Apr 27;60(8):3275-3288
pubmed: 28418653
Bioorg Med Chem Lett. 2022 Oct 1;73:128909
pubmed: 35907608
Eur J Med Chem. 2019 Jan 1;161:581-593
pubmed: 30396105
ISRN Mol Biol. 2012;2012:
pubmed: 24236237
J Cancer Sci Ther. 2014 Jul 25;6(7):258-267
pubmed: 25232464
Br J Pharmacol. 2013 Aug;169(8):1745-65
pubmed: 23682925
Mol Cancer Ther. 2014 Jan;13(1):214-20
pubmed: 24130054
EMBO J. 2005 Jun 15;24(12):2224-33
pubmed: 15920477
Nat Protoc. 2013 Nov;8(11):2281-2308
pubmed: 24157548
Biochem Pharmacol. 2012 Jan 1;83(1):27-36
pubmed: 21978643
Bioorg Med Chem. 2016 Apr 1;24(7):1469-79
pubmed: 26906474
Cancer Chemother Pharmacol. 2004 Feb;53(2):107-15
pubmed: 14605862
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15387-92
pubmed: 12426403
J Biol Chem. 2011 Jan 7;286(1):403-9
pubmed: 21030584
Nucleic Acids Res. 2016 May 5;44(8):3829-44
pubmed: 27060144
J Med Chem. 2019 May 9;62(9):4669-4682
pubmed: 30998359
Molecules. 2021 Dec 23;27(1):
pubmed: 35011303
PLoS Genet. 2013;9(3):e1003226
pubmed: 23505375
Nucleic Acids Res. 2012 Sep 1;40(17):8371-80
pubmed: 22740648
DNA Repair (Amst). 2014 Jul;19:114-29
pubmed: 24856239
Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12009-14
pubmed: 11572945
Nat Struct Mol Biol. 2012 Dec;19(12):1363-71
pubmed: 23104055