Targeted Therapies in Advanced Cholangiocarcinoma.
cholangiocarcinoma
systemic therapy
targeted therapy
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
16 Oct 2023
16 Oct 2023
Historique:
received:
31
08
2023
revised:
02
10
2023
accepted:
13
10
2023
medline:
28
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
Primary tumor resection and liver transplantation are the only curative treatment options for the management of cholangiocarcinoma (CCA). However, for patients with advanced or metastatic disease, palliative systemic therapy remains the only treatment option. The development of targeted therapeutics has begun to shift the treatment paradigm in CCA. Targets of interest in CCA include mutated isocitrate dehydrogenase-1 (mIDH-1), human epidermal growth factor receptor 2 (HER2) overexpression/amplification, and fibroblast growth factor receptor 2 (
Identifiants
pubmed: 37895447
pii: life13102066
doi: 10.3390/life13102066
pmc: PMC10608206
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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