Modulation of Neuron and Astrocyte Dopamine Receptors via Receptor-Receptor Interactions.
GPCR
Parkinson’s disease
Schizophrenia
dopaminergic pathways
drug addiction
receptor complexes
receptor–receptor interactions
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
08 Oct 2023
08 Oct 2023
Historique:
received:
11
09
2023
revised:
29
09
2023
accepted:
04
10
2023
medline:
28
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
Dopamine neurotransmission plays critical roles in regulating complex cognitive and behavioral processes including reward, motivation, reinforcement learning, and movement. Dopamine receptors are classified into five subtypes, widely distributed across the brain, including regions responsible for motor functions and specific areas related to cognitive and emotional functions. Dopamine also acts on astrocytes, which express dopamine receptors as well. The discovery of direct receptor-receptor interactions, leading to the formation of multimeric receptor complexes at the cell membrane and providing the cell decoding apparatus with flexible dynamics in terms of recognition and signal transduction, has expanded the knowledge of the G-protein-coupled receptor-mediated signaling processes. The purpose of this review article is to provide an overview of currently identified receptor complexes containing dopamine receptors and of their modulatory action on dopamine-mediated signaling between neurons and between neurons and astrocytes. Pharmacological possibilities offered by targeting receptor complexes in terms of addressing neuropsychiatric disorders associated with altered dopamine signaling will also be briefly discussed.
Identifiants
pubmed: 37895898
pii: ph16101427
doi: 10.3390/ph16101427
pmc: PMC10610355
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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