The Development of a Smart Magnetic Resonance Imaging and Chemical Exchange Saturation Transfer Contrast Agent for the Imaging of Sulfatase Activity.
CEST
MRI
molecular imaging
responsive imaging agents
sulfatase
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
11 Oct 2023
11 Oct 2023
Historique:
received:
11
08
2023
revised:
04
10
2023
accepted:
09
10
2023
medline:
28
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
The molecular imaging of biomarkers plays an increasing role in medical diagnostics. In particular, the imaging of enzyme activity is a promising approach, as it enables the use of its inherent catalytic activity for the amplification of an imaging signal. The increased activity of a sulfatase enzyme has been observed in several types of cancers. We describe the development and in vitro evaluation of molecular imaging agents that allow for the detection of sulfatase activity using the whole-body, non-invasive MRI and CEST imaging methods. This approach relies on a responsive ligand that features a sulfate ester moiety, which upon sulfatase-catalyzed hydrolysis undergoes an elimination process that changes the functional group, coordinating with the metal ion. When Gd
Identifiants
pubmed: 37895910
pii: ph16101439
doi: 10.3390/ph16101439
pmc: PMC10610007
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
ACS Sens. 2023 May 26;8(5):2021-2029
pubmed: 37167101
Angew Chem Int Ed Engl. 2001 Aug 3;40(15):2903-2906
pubmed: 29711998
Chemistry. 2016 May 4;22(19):6491-5
pubmed: 26956002
Appl Radiat Isot. 2002 Nov;57(5):687-95
pubmed: 12433043
Front Pharmacol. 2023 Apr 28;14:1155558
pubmed: 37188267
Physiol Rev. 2012 Apr;92(2):897-965
pubmed: 22535898
Invest Radiol. 1988 Sep;23 Suppl 1:S229-31
pubmed: 3198350
Mol Biosyst. 2009 Nov;5(11):1279-91
pubmed: 19823742
Endocr Rev. 2005 Apr;26(2):171-202
pubmed: 15561802
Dalton Trans. 2013 Nov 28;42(44):15735-47
pubmed: 24051547
Expert Opin Ther Pat. 2021 Jun;31(6):453-472
pubmed: 33783295
Chem Rev. 2019 Jan 23;119(2):957-1057
pubmed: 30350585
J Nucl Med. 2009 Aug;50(8):1199-202
pubmed: 19617320
Biochem J. 2020 Oct 30;477(20):3963-3983
pubmed: 33120425
Contrast Media Mol Imaging. 2006 Sep-Oct;1(5):184-8
pubmed: 17193695
J Am Chem Soc. 2023 May 10;145(18):10045-10050
pubmed: 37116079
Steroids. 2009 Nov;74(12):896-905
pubmed: 19559719
Pharmaceuticals (Basel). 2020 Oct 08;13(10):
pubmed: 33050049
Metallomics. 2015 Mar;7(3):405-21
pubmed: 25579206
Theranostics. 2022 Jan 1;12(3):1459-1485
pubmed: 35154500
J Am Chem Soc. 2005 Sep 21;127(37):12847-55
pubmed: 16159278
Angew Chem Int Ed Engl. 2008;47(23):4370-2
pubmed: 18454438
Org Lett. 2012 Aug 3;14(15):3902-5
pubmed: 22799566
Biomed Imaging Interv J. 2006 Apr;2(2):e8
pubmed: 21614236
Contrast Media Mol Imaging. 2015 Jul-Aug;10(4):245-65
pubmed: 25355685
Chemistry. 2014 Aug 4;20(32):9840-50
pubmed: 24990812
Mol Imaging. 2017 Jan-Dec;16:1536012117717852
pubmed: 28927325
J Am Chem Soc. 2006 Feb 8;128(5):1605-10
pubmed: 16448132