Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend
Alzheimer’s disease
aggregation
glycogen synthase kinase 3β (GSK3β)
molecular modeling
neurodegeneration
neurodegenerative disease
protein aggregation
proteostasis
thiadiazolidinones (TDZDs)
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
20 Oct 2023
20 Oct 2023
Historique:
received:
25
08
2023
revised:
29
09
2023
accepted:
02
10
2023
medline:
28
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
Chronic, low-grade inflammation has been implicated in aging and age-dependent conditions, including Alzheimer's disease, cardiomyopathy, and cancer. One of the age-associated processes underlying chronic inflammation is protein aggregation, which is implicated in neuroinflammation and a broad spectrum of neurodegenerative diseases such as Alzheimer's, Huntington's, and Parkinson's diseases. We screened a panel of bioactive thiadiazolidinones (TDZDs) from our in-house library for rescue of protein aggregation in human-cell and
Identifiants
pubmed: 37895969
pii: ph16101498
doi: 10.3390/ph16101498
pmc: PMC10610358
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Institute on Aging (NIA/NIH)
ID : Program Project Grant 2P01AG012411-17A1 (W.S.T. Griffin, P.I.)
Organisme : U.S. Dept. of Veteran Affairs; to M.B. from the Inglewood Scholars Program
ID : (VA Merit 2 I01 BX001655 and Senior Research Career Scientist Award) to R.J.S.R.
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